A5050484781- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Circular RNAs in diseases
- Gastrointestinal disorders and treatments
- Alcohol Consumption and Health Effects
- Abdominal Trauma and Injuries
- Advanced biosensing and bioanalysis techniques
- Celiac Disease Research and Management
- Herpesvirus Infections and Treatments
- Microscopic Colitis
- Sarcoma Diagnosis and Treatment
- Ultrasound and Hyperthermia Applications
- Organ Transplantation Techniques and Outcomes
- Cardiovascular Disease and Adiposity
- Axon Guidance and Neuronal Signaling
- Epigenetics and DNA Methylation
- Pancreatitis Pathology and Treatment
- Histone Deacetylase Inhibitors Research
- Angiogenesis and VEGF in Cancer
- Colorectal Cancer Screening and Detection
- melanin and skin pigmentation
University of Trieste
2019-2024
Ospedale di Cattinara
2024
Azienda Sanitaria Universitaria Integrata di Trieste
2019-2022
Candiolo Cancer Institute
2017-2018
University of Turin
2017
Abstract Metastasis formation requires active energy production and is regulated at multiple levels by mitochondrial metabolism. The hyperactive metabolism of cancer cells supports their extreme adaptability plasticity facilitates resistance to common anticancer therapies. In spite the potential relevance a metastasis metabolic control therapy, so far, limited experience available in this direction. Here, we evaluated effect recently described α-ketoglutarate dehydrogenase (KGDH) inhibitor,...
This study aims to measure the values of spleen stiffness (SS) in healthy subjects, inter-operator agreement SS measurement, and detect statistically significant correlations between age, sex, weight, BMI, portal vein dynamics splenic dimensions.The included 100 volunteers who had no substantial alcohol intake (<30g/daily for man, <20g/daily women), were negative on hepatitis B, C, HIV blood serology, any history lymphoproliferative disorders. Abdominal ultrasound, liver elastography...
Non-selective beta-blockers (NSBB) are used for primary prophylaxis in patients with liver cirrhosis and high-risk varices (HRVs). Assessing therapeutic response is challenging due to the invasive nature of hepatic venous pressure gradient (HVPG) measurement. This study aims define a noninvasive machine-learning based approach determine NSBB HRVs. We conducted prospective on cohort cirrhotic documented HRVs receiving treatment. Patients were followed-up clinical elastography appointments at...
The clinical outcome of hepatocellular carcinoma (HCC) treatment remains unsatisfactory, contributing to the high mortality HCC worldwide. Circulating miRNAs have potential be a predictor therapy response. Microarray profiling was performed in serum samples 20 patients before treatment. associated with response were validated 86 using qRT-PCR system. Patients treated either curative treatments (resection or radiofrequency) trans-arterial chemoembolization (TACE), and grouped according...
Introduction: Hepatocellular carcinoma (HCC) is the sixth most diagnosed malignancy and fourth leading cause of cancer-related death worldwide, with poor overall survival despite available curative treatments. One crucial factors influencing in HCC recurrence. The current study aims to determine associated early recurrence patients BCLC Stage 0 or A treated surgical resection local ablation. Materials Methods: We retrospectively enrolled 58 consecutive within either by ablation maximum...
Molecular pathways governing blood vessel patterning are vital to vertebrate development. Because of their ability counteract proangiogenic factors, antiangiogenic secreted Sema3 (class 3 semaphorins) control embryonic vascular morphogenesis. However, if and how may play a role in the extraembryonic development is presently unknown.By characterizing genetically modified mice, here, we show that surprisingly Sema3F acts instead as selective extraembryonic, but not intraembryonic cue. Both...
BACKGROUNDHepatocellular carcinoma (HCC) represents the most common primitive liver malignancy.A relevant concern involves lack of agreement on staging systems, prognostic scores, and treatment allocation algorithms. AIMTo compare survival rates among already developed scores. METHODSWe retrospectively evaluated 140 patients with HCC diagnosed between February 2006 November 2017.Patients were categorized according to 15 scoring systems estimated median survivals compared those available from...
Background: Hepatic resection, radiofrequency ablation (RF), and liver transplantation (LT) represent the only available curative treatments for early stage hepatocellular carcinoma (HCC). Various studies showed that 5-year overall survival (OS) rate reaches ∼70% after resection ∼60% RF. Objective: To improve success of therapies consequently OS, an improvement in patients’ selection management should be pursued. In this regard, microRNAs (miRNAs) can helpful prognostic biomarkers. Materials...
Intestinal anti-endomysium antibodies are a specific marker of celiac disease. The diagnostic accuracy this seems high in pediatric patients and has not yet been investigated adults, so the aim prospective multicentric study was to evaluate specificity sensitivity childhood adulthood. Pediatric adult undergoing intestinal endoscopy for any condition were enrolled. Serological disease markers HLA type evaluated all patients. biopsies analyzed standard histology with biopsy culture assay. In...