A5000073239- Helicobacter pylori-related gastroenterology studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Spectroscopy and Chemometric Analyses
- Pneumonia and Respiratory Infections
- Mycobacterium research and diagnosis
- Nosocomial Infections in ICU
- Inflammatory Bowel Disease
- Advanced Chemical Sensor Technologies
- Digestive system and related health
- Food composition and properties
- Blood groups and transfusion
- Liver Diseases and Immunity
- Bee Products Chemical Analysis
- Antibiotic Use and Resistance
- Macrophage Migration Inhibitory Factor
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Health and Disease Prevention
- Biomedical Research and Pathophysiology
- Sepsis Diagnosis and Treatment
- Cystic Fibrosis Research Advances
- Cytokine Signaling Pathways and Interactions
- Magnetic confinement fusion research
- Clostridium difficile and Clostridium perfringens research
University of Trieste
2016-2022
Creative Research Enterprises (United States)
2019
Istituti di Ricovero e Cura a Carattere Scientifico
2019
IRCCS Materno Infantile Burlo Garofolo
2019
Showa University Fujigaoka Hospital
2019
Centro di Riferimento Oncologico
2018
Intensive Care Foundation
2001
University of Udine
2000
Abstract Intense label-free surface-enhanced Raman scattering (SERS) spectra of serum samples were rapidly obtained on Ag plasmonic paper substrates upon 785 nm excitation. Spectra from the hepatocellular carcinoma (HCC) patients showed consistent differences with respect to those control group. In particular, uric acid was found be relatively more abundant in patients, while hypoxanthine, ergothioneine, and glutathione as A repeated double cross-validation (RDCV) strategy applied optimize...
Glucocorticoids (GCs) are widely employed in inflammatory, autoimmune and neoplastic diseases, and, despite the introduction of novel therapies, remain first-line treatment for inducing remission inflammatory bowel disease (IBD). Given high incidence suboptimal response, associated with a significant number side-effects, that particularly severe paediatric patients, identification subjects most likely to respond poorly GCs is extremely important. Recent evidence suggests long non-coding RNA...
The long non-coding RNA (lncRNA) growth arrest-specific transcript 5 (GAS5) seems to be involved in the regulation of mediators tissue injury, particular matrix metalloproteinases (MMPs), implicated pathogenesis inflammatory bowel disease (IBD). We investigated role GAS5 regulating MMP2 and MMP9 expression pediatric patients with IBD vitro. In total, 25 were enrolled: For each patient paired inflamed non-inflamed biopsies collected. was extracted GAS5, MMP2, quantified by TaqMan assay. MMPs...
The objective of this prospective, randomized, double-blind study was to evaluate the effect addition mupirocin 'classical' topical SDD regimen (tobramycin 80 mg, polymyxin E 100 amphotericin B 500 mg) on development ICU-acquired infections due Gram-positive bacteria. carried out in an intensive care unit (ICU) a 1400-bed community hospital. All patients admitted ICU during 16-month period, who were expected require mechanical ventilation for more than 24 hours, randomized receive either...
The aim of this research was the identification novel pharmacogenomic biomarkers for better understanding complex gene regulation mechanisms underpinning glucocorticoid (GC) action in paediatric inflammatory bowel disease (IBD). This goal achieved by evaluating high-throughput microRNA (miRNA) profiles during GC treatment, integrated with assessment expression changes receptor (GR) heterocomplex genes. Furthermore, we tested hypothesis that differentially expressed miRNAs could be directly...
Abstract Glucocorticoids (GCs) are commonly used as therapeutic agents for immune-mediated diseases and leukemia. However, considerable inter-individual differences in efficacy have been reported. Several reports indicate that the inhibitor of mTOR rapamycin can reverse GC resistance, but molecular mechanism involved this synergistic effect has not fully defined. In context, we explored differential miRNA expression a GC-resistant CCRF-CEM cell line after treatment with alone or co-treatment...
Surface-enhanced Raman scattering (SERS) spectra of faecal samples can be obtained by adding AuNP to their methanol extracts according the reported protocol, and display bands that are due bilirubin-like species but also xanthine hypoxanthine, two metabolic products secreted gut bacteria. A total 27 from three different groups, i.e. coeliac patients (n = 9), on gluten-free diet 10) a control group 8), were characterized with both SERS spectroscopy 16S rRNA sequencing analysis. Significant...
BACKGROUNDIntestinal inflammation and epithelial injury are the leading actors of inflammatory bowel disease (IBD), causing an excessive pro-inflammatory cytokines expression.Tristetraprolin (TTP), mRNA binding protein, plays a role in regulating factors, recognizing specific sequences on 3' untranslated region cytokine mRNAs.TTP activity depends its phosphorylation state: unphosphorylated TTP degrades mRNAs; contrary, phosphorylated fails to destabilize mRNAs furthering their expression.The...
The awareness of the diagnostic difficulty and documented high mortality risk perioperative myocardial infarction (PMI) has led to wide use work up rule out PMI after major noncardiac operations.This caused stable postoperative patients be kept in monitored hospital beds for extended periods time subjected additional tests.We hypothesized that is and, therefore, identify these justifiable.We performed following study prove our hypothesis.All recovery room operations who underwent were...
Background: Despite the introduction of novel biological therapies, glucocorticoids (GCs) remain widely used for inducing remission in inflammatory bowel diseases (IBD), particular ulcerative colitis. Given high incidence suboptimal response, associated with a significant number side effects, that are particularly severe paediatric patients, identification subjects most likely to respond poorly GCs is extremely important. In this context, recent results obtained our laboratory suggest role...