About
Contact & Profiles
A5100441507
Research Areas
- Synthetic Organic Chemistry Methods
- Marine Sponges and Natural Products
- Chemical synthesis and alkaloids
Hong Kong University of Science and Technology
2017
University of Hong Kong
2017
Abstract Ansellane‐type sesterterpenoids including, ansellones A‐G and (+)‐phorbadione are structurally novel marine secondary metabolites which exhibit anticancer anti‐HIV activity. The first, asymmetric total syntheses of three representative members, (−)‐ansellones A B (+)‐phorbadione, were accomplished in 16–23 steps from (+)‐sclareolide. route features the first regioselective cyclization vinyl epoxides with internal alcohol nucleophiles a 1,4‐addition manner (S N 2′). Additionally,...
10.1002/ange.201701879
article
EN
Angewandte Chemie
2017-03-28
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