A5009299826- Forensic Toxicology and Drug Analysis
- Opioid Use Disorder Treatment
- Cannabis and Cannabinoid Research
- Pharmacological Receptor Mechanisms and Effects
- Consumer Packaging Perceptions and Trends
- Effects and risks of endocrine disrupting chemicals
- Neurotransmitter Receptor Influence on Behavior
- Advanced Chemical Sensor Technologies
- Microplastics and Plastic Pollution
- Psychedelics and Drug Studies
- Poisoning and overdose treatments
- Mass Spectrometry Techniques and Applications
- Analytical Chemistry and Chromatography
- Pain Mechanisms and Treatments
- Listeria monocytogenes in Food Safety
- Occupational exposure and asthma
- Contact Dermatitis and Allergies
- Antimicrobial agents and applications
- Pharmaceutical and Antibiotic Environmental Impacts
- Chemistry and Chemical Engineering
- Pharmacogenetics and Drug Metabolism
- Veterinary Pharmacology and Anesthesia
- Bacterial Identification and Susceptibility Testing
- Historical and Scientific Studies
- Pain Management and Opioid Use
Laboratoires Spiral (France)
2021
Délégation Paris 5
2007-2010
Inserm
2003-2010
Université Paris Cité
2005-2010
Centre National de la Recherche Scientifique
2005-2010
Délégation Paris 7
2009
Canadian Nautical Research Society
2009
Institut National de Police Scientifique
2002-2008
National Institute on Drug Abuse
2006-2007
National Institutes of Health
2006-2007
Drug interaction with P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) may influence its tissue disposition including blood-brain barrier transport result in potent drug-drug interactions. The limited data obtained using in-vitro models indicate that methadone, buprenorphine, cannabinoids interact human P-gp; but almost nothing is known about drugs of abuse BCRP. We used vitro P-gp BCRP inhibition flow cytometric assays hMDR1- hBCRP-transfected HEK293 cells to test 14...
A sensitive and specific method for extraction quantification of Δ9-tetrahydrocannabinol (THC), 11-hydroxy-Δ9-tetrahydrocannabinol (11-OH-THC), 11-nor-9-carboxy-Δ9-tetrahydrocannabinol (THCCOOH) in human urine was developed fully validated. To ensure complete hydrolysis conjugates capture total analyte content, samples were hydrolyzed by two methods series. Initial with Escherichia coli β-glucuronidase (Type IX-A) followed a second utilizing 10N NaOH. Specimens adjusted to pH 5–6.5, treated...
Abstract Objective The increasing demand for eco‐friendly cosmetic products, along with tightening environmental regulations, necessitates a comprehensive evaluation of the impact formulations. This study aims to develop an ecotoxicological scoring system, specifically designed cosmetics, quantify ecological risk product ingredients. tool will assist industry professionals in selecting ingredients lower impacts while complying safety and sustainability requirements. Methods Key parameters...
3,4-Methylenedioxymethamphetamine (MDMA), or ecstasy, is excreted as unchanged drug, 3,4-methylenedioxyamphetamine (MDA), and free glucuronidated/sulfated 4-hydroxy-3-methoxymethamphetamine (HMMA), 4-hydroxy-3-methoxyamphetamine (HMA) metabolites. The aim of this paper to describe the pattern timeframe excretion MDMA its metabolites in urine. Placebo, 1.0 mg/kg, 1.6 mg/kg oral doses were administered double-blind healthy adult users on a monitored research unit. All urine was collected,...
Fatalities have been attributed to combinations of high-dose buprenorphine with benzodiazepines. In rats, combined midazolam was shown induce sustained respiratory acidosis, while alone did not. However, the effects pharmacological doses benzodiazepines remain unknown. Our objective compare acute four selected used intravenously at equi-efficacious in and combination on sedation, rate arterial blood gases. Buprenorphine (30 mg/kg) not significantly modify sedation level or rate, but induced...
Ethanol, pH and water activity are three well-known parameters that can influence the preservation of cosmetic products. With new constraints regarding antimicrobial effectiveness restrictive use preservatives, a D-optimal design was set up to evaluate these on microbiological conservation.To monitor different combination parameters, challenge test in compliance with International standard ISO 11930: 2012 implemented. The formulations established our study could support wide variations...
Abstract Background: A sensitive gas chromatography-mass spectrometry method was developed and validated for the simultaneous measurement of MDEA, MDMA, its metabolites, 3,4-methylenedioxy-N-ethylamphetamine (MDEA), 3,4-methylenedioxymethamphetamine (MDMA or Ecstasy), 4-hydroxy-3-methoxyamphetamine (HMA), 3,4-methylenedioxyamphetamine (MDA), (HMMA) in human urine. Methods: We hydrolyzed 1 mL urine, fortified with MDMA-d5, MDA-d5, MDEA-d6, 100 μL concentrated hydrochloric acid at 120 °C 40...
Recovery of 3,4-methylenedioxymethamphetamine (MDMA) urinary metabolites requires optimization the hydrolysis 4-hydroxy-3-methyoxymethamphetamine (HMMA), 4-hydroxy-3-methoxyamphetamine (HMA), and 3,4-methylenedioxyamphelamine (MDA) conjugates prior to chromatographic analysis. Acidic enzymatic with β-glucuronidase from Escherichia coli Helix pomatia were evaluated. Acid yielded 40.0% 39.3% higher HMA recovery compared E. H. hydrolysis, respectively (SE = 9.8 11.4%). MDA was 17.1% 26.5%...
High-dosage buprenorphine (BUP) consumed concomitantly with benzodiazepines (BZDs) including flunitrazepam (FZ) may cause life-threatening respiratory depression despite a BUP ceiling effect and BZDs' limited effects on ventilation. However, the mechanism of BUP/FZ interaction remains unknown. We hypothesized that alter disposition FZ active metabolites in vivo, contributing to toxicity. Plasma FZ, desmethylflunitrazepam (DMFZ), 7-aminoflunitrazepam (7-AFZ) concentrations were measured using...
Assessing brain death may sometimes be difficult, with isoelectric EEG following psychotrope overdoses or normal cerebral blood flow (CBF) persisting despite in the case of ventricular drainage craniotomy. A 42-year-old man, resuscitated after cardiac arrest a suicidal ingestion ethanol, bromazepam and zopiclone, was admitted deep coma. On day 4, his brainstem reflexes activity disappeared. 5, serum concentration 817 ng/ml (therapeutic: 80-150). The patient unresponsive to 1 mg flumazenil....
Challenge test (CT) is essential to assure the efficiency of preservative system in products. A previous study realized by our staff 2012, carried out evaluate influence three parameters (ethanol, pH and water) on microbiological cosmetics products conservation. Following this work, a correlation between aw (based glycerine concentration) selected parameter has been demonstrated. In present study, smaller limits ethanol, were applied determinate CT necessity.Sixteen stables O/W creams with...
The present work is devoted to the structural elucidation of by-products issued from direct ultraviolet-visible (UV-vis) irradiation dehydroacetic acid (DHA) in solution and cosmetic emulsion.Analyses were carried out using gas chromatography coupled with ion trap mass spectrometry by high-performance liquid ultrahigh-resolution Fourier transform cyclotron resonance (LC/UHRMS). potential toxicities estimated silico calculations based on a QSAR (Quantitative Structure-Activity Relationship)...
Synopsis Objective Since the publication of Regulation ( EC ) No 1223/2009 on cosmetic products, content‐containing interaction between packaging and product must be considered for safety assessment product. Indeed, some compounds are able to migrate from may harmful consumer health. The developed validated method investigation was applied 79 products. Methods Packaging materials products at risk were determined by studying data information files assessed EXPERTOX . To evaluate interaction,...
Staff members of psychiatric facilities are at high risk secondhand smoking. Smoking exposure was assessed in 41 nonsmoking employees a psychiatry department before and after ban. Subjective measures decreased 76% the subjects. Salivary cotinine subsample seven subjects with pre-ban levels (32+/-8 vs 40+/-17 ng/ml, p=.045).