A5078637761- Cancer therapeutics and mechanisms
- Click Chemistry and Applications
- Phytochemicals and Antioxidant Activities
- Natural product bioactivities and synthesis
- Catalytic C–H Functionalization Methods
- Free Radicals and Antioxidants
- Cancer Mechanisms and Therapy
- Synthesis of Organic Compounds
- Protein Degradation and Inhibitors
- Hepatitis C virus research
- Peroxisome Proliferator-Activated Receptors
- Bioactive natural compounds
- PI3K/AKT/mTOR signaling in cancer
- Synthesis and biological activity
- Telomeres, Telomerase, and Senescence
- Carbohydrate Chemistry and Synthesis
- Antioxidant Activity and Oxidative Stress
- Traditional Chinese Medicine Analysis
- Inflammatory Bowel Disease
- Advanced Breast Cancer Therapies
- Bioactive Compounds and Antitumor Agents
- Natural Antidiabetic Agents Studies
- Peptidase Inhibition and Analysis
- Advanced biosensing and bioanalysis techniques
- Monoclonal and Polyclonal Antibodies Research
Tianjin University of Science and Technology
2015-2024
China International Science and Technology Cooperation
2016-2024
A series of multi-substituted isatin derivatives were synthesized using the powerful Sandmeyer reaction. The structures these confirmed by 1H-NMR, 13C-NMR, and HR-MS. Inhibition proliferation activities against human leukemia cells (K562), hepatocellular carcinoma (HepG2) colon (HT-29) evaluated in vitro MTT assay. Among series, compound 4l exhibited strong antiproliferatory K562, HepG2 HT-29 with IC50 values 1.75, 3.20, 4.17 μM, respectively. morphological, growth inhibitory apoptosic...
Abstract A concise and practical method for the metal‐free synthesis of 1,8‐naphthyridones is described using a two‐step approach involving regioselective amination pyridine N ‐oxides acid‐mediated cyclization. This first utilizing easily accessible as substrates. Compared to previous reports, this benefits from simple operation, easy access starting materials, wide substrate scope, providing variety novel 1,8‐naphthyridones. magnified image
The effect of the combination 10-Hydroxycamptothecin (HCPT) and crizotinib (CRI) on EGFR- KRAS-mutant lung cancer cells was investigated conjugates two drugs were synthesised. HCPT combined with CRI synergistically inhibited cell growth proliferation H1975, HCC827, H460 without aggravating adverse normal cells. enhanced apoptosis rate through releasing Cyto-C by activation Bcl-2 family-mediated mitochondrial signalling, which associate inactivating EGFR related downstream signalling pathways...
Flavonoids are widely found in plants and diets considered to possess a variety of biological activities. Therefore, this study, 8 novel compounds derivating from the precursor compound 1a, were designed synthesized, their activities against ulcerative colitis(UC) evaluated provide most active molecule 2d. Both cellular inflammation model by LPS(Lipopolysaccharide)-induced RAW 264.7 cells UC 2 % Dextran Sulfate Sodium(DSS) intragastrically injected mice established employed detect validate...
(±)-Anastatins A and B are flavonoids isolated from Anastatica hierochuntica. In a previous study, twenty-four di- tri-substituted novel derivatives of anastatins were designed their preliminary antioxidant activities evaluated. the present protective effect myocardial ischemia-reperfusion (I/R) systematic capacity 24 further studied. Compound 13 was most potent among all compounds studied, which increased survival H9c2 cells to 80.82%. The capability compound evaluated in ferric reducing...
Three 3-substituted derivatives of quercetin were synthesized in 10-80% overall yields.Their structures characterized by 1 HNMR.Three target compounds (4a~4c) have not been reported before.The results showed that: pre-treated PC-12 cells with, cell survival rate was higher than that quercetin.In this project, the oxidative damage model established and antioxidant activities three newly evaluated.Among them, compound 4b (30μM) highest activity against H 2 O .Cell viability with or without...