A5074444499- Computational Drug Discovery Methods
- Malaria Research and Control
- HIV/AIDS drug development and treatment
- Synthesis and bioactivity of alkaloids
- Enzyme Production and Characterization
- Bacillus and Francisella bacterial research
- Multicomponent Synthesis of Heterocycles
- Synthesis and biological activity
- Click Chemistry and Applications
- Synthesis of heterocyclic compounds
- Bacteriophages and microbial interactions
- Poxvirus research and outbreaks
Federal University of São João del-Rei
2022-2024
Abstract Dipteryx lacunifera is an example of the Brazilian cerrado flora which recently showed promising biological actions, such as antioxidant and antibacterial activities a potential antimalarial effect. This study evaluated three flavonoids isolated from fruits kernels D. lacunifera, 7,3´, 4´-trihydroxyflavone (1), 7,3´,4´-trihydroxyflavanone (2), (-)-eriodictyol (3). Virtual molecular modeling platforms (in silico), chemotherapy assays with P. falciparum W2 strain, cytotoxicity vitro)...
N-heterocyclic compounds are important molecular scaffolds in the search for new drugs, since most drugs contain heterocyclic moieties their structure, and some of these classes heterocycles able to provide ligands two or more biological targets. Ketene dithioacetals building blocks organic synthesis widely used compounds. In this work, we double vinylic substitution reactions on ketene synthesize a small library derivatives evaluated cytotoxic activity breast ovarian cancer cells,...
N-acylhydrazones are considered privileged structures in medicinal chemistry, being part of antimicrobial compounds (for example). In this study we show the activity N-acylhydrazone compounds, namely AH1, AH2, AH4, AH5 vitro tests against chloroquine-resistant strain Plasmodium falciparum (W2) and WI26 VA-4 human cell lines. All showed low cytotoxicity (LC50 > 100 µM). The compound was most active falciparum, with an IC50 value 0.07 μM. AH4 were selected among tested for molecular docking...
Malaria is an infectious disease widespread in underdeveloped tropical regions. The most severe form of infection caused by Plasmodium falciparum, which can lead to development cerebral malaria (CM) and responsible for deaths significant neurocognitive sequelae throughout life. In this context considering the emergence spread drug-resistant P. falciparum isolates, search new antimalarial candidates becomes urgent. β-carbolines alkaloids are good since a wide range biological activity these...
Abstract N -acylhydrazones are considered privileged structures in medicinal chemistry, being part of antimicrobial compounds (for example). In this study we show the activity -acylhydrazone compounds, namely AH1, AH2, AH4, AH5 vitro tests against chloroquine-resistant strain Plasmodium falciparum (W2) and WI26 VA-4 human cell lines. All showed low cytotoxicity (LC 50 > 100 µM). The 5 compound was most active , with an IC value 0.07 µM. 4 were selected among tested for molecular docking...
Malaria continues a scourge to many countries in the world, having long spread tropical underdeveloped regions. The most severe form of infection is caused by Plasmodium falciparum, which can lead development cerebral malaria, and responsible for deaths significant neurocognitive sequelae throughout life, even with administration adequate antimalarial treatment. In this context, considering emergence drug resistant isolates P. it becomes urgent search new candidates that positively aid...