A5045818259- Phytochemistry Medicinal Plant Applications
- Essential Oils and Antimicrobial Activity
- Research on Leishmaniasis Studies
- Insect Pest Control Strategies
- Phytochemicals and Antioxidant Activities
- Synthesis and biological activity
- Trypanosoma species research and implications
- Agricultural and Food Sciences
- Traditional and Medicinal Uses of Annonaceae
- Ethnobotanical and Medicinal Plants Studies
- Pineapple and bromelain studies
- Phytochemicals and Medicinal Plants
- Piperaceae Chemical and Biological Studies
- Bee Products Chemical Analysis
- Synthesis and Biological Evaluation
- Synthesis and bioactivity of alkaloids
- Tannin, Tannase and Anticancer Activities
- Computational Drug Discovery Methods
- Phytochemistry and Biological Activities
- Dye analysis and toxicity
- Natural Antidiabetic Agents Studies
- Nanocomposite Films for Food Packaging
- Vector-borne infectious diseases
- Legume Nitrogen Fixing Symbiosis
- Multicomponent Synthesis of Heterocycles
Universidade Federal de Juiz de Fora
2020-2025
Ursolic acid (UA) is a pentacyclic triterpenoid known for its wide range of biological activities, including anticancer and antimicrobial effects. However, poor solubility in water limits therapeutic potential. Therefore, this work aims to evaluate the physicochemical properties ursolic acid/β-cyclodextrin inclusion complex (UA/βCD IC) investigate enhancement vitro antitumor antibacterial activities UA when complexed with βCD. Molecular docking simulation showed that carbonyl group binds...
Ravenala madagascariensis, the Traveler's tree, is native to Madagascar but has adapted globally and utilized for medical cosmetic purposes. Focusing on brightly blue colored arils of plant's seeds, this study aimed examine their morphological physicochemical properties shed light upon previously undescribed structure pigment. Plant were examined by energy-dispersive X-ray spectroscopy (EDS) scanning electron microscopy (SEM). Centesimal analyses indicated a lipid-rich composition (81.45%),...
Macauba oil-loaded polymeric micelles exhibit antimigratory, antiproliferative, and cytotoxic activities in triple-negative breast cancer cells, suggesting potential as a therapeutic agent for this aggressive type.
Leishmania poses a substantial threat to the human population all over globe because of its visceral and cutaneous spread engendered by 20 species. Unfortunately, available drugs against leishmania are already hobbled with toxicity, prolonged treatment, increasing instances acquirement resistance. Under these grave circumstances, development new has become imperative keep harmful microbes at bay. To this end, Groebke-Blackburn-Bienaymé multicomponent reaction-based library different...
Vulvovaginal candidiasis (VVC) is characterized by inflammatory changes in the vaginal mucosa caused abnormal colonization of Candida species. Traditional topical therapies using reference antifungal drugs usually present several issues and limitations for VVC treatment. Thus, interest new formulations, mainly those based on compounds from natural origin, has been growing over last years. Methanolic extract plant species Mitracarpus frigidus (Willd. Ex Reem Schult.) K. Schum (MFM) presented...
This study aimed to evaluate the potential of aqueous extract from Mitracarpus frigidus aerial parts (MFAq) in treatment inflammation and oxidative stress, as well characterize its chemical constituents.Total phenolic flavonoid contents were determined, phytoconstituents detected by ultra-fast liquid chromatography/quadrupole-time-of-flight tandem mass spectrometry (UFLC-QTOF-MS). The antioxidant activity was evaluated DPPH, TAC β-carotene/linoleic acid assays. In-vitro anti-inflammatory...
Abstract Despite efforts, available alternatives for the treatment of leishmaniasis are still scarce. In this work we tested a class 15 quinolinylhydrazone analogues and presented data that support use most active compound in cutaneous caused by Leishmania amazonensis . general, compounds showed activity at low concentrations both parasitic forms (5.33–37.04 μM to promastigotes, 14.31–61.98 amastigotes). addition, best ( MHZ15 ) is highly selective parasite. Biochemical studies indicate...
Leishmaniasis is a disease caused by protozoa Leishmania spp., considered as significant and urgent public health problem mainly in developing countries. In the absence of an effective vaccine, treatment infected people one most commonly prophylactic measures used to control this disease. However, therapeutic arsenal reduced few drugs, with serious side effects variability efficacy. Attempting problem, work, series benzothiazole derivatives was synthetized assayed against promastigotes...
Abstract Antimicrobial resistance is a pressing global health concern, demanding the development of novel antimicrobial agents. Quinoline derivatives emerge as promising candidates with their diverse chemical structures and recognized bioactive properties. This study aimed to investigate potency newly synthesized quinoline against Candida albicans five bacterial strains, which are responsible for various infections have exhibited varying degrees antibiotic resistance. A series were through...
Malaria is an infectious disease widespread in underdeveloped tropical regions. The most severe form of infection caused by Plasmodium falciparum, which can lead to development cerebral malaria (CM) and responsible for deaths significant neurocognitive sequelae throughout life. In this context considering the emergence spread drug-resistant P. falciparum isolates, search new antimalarial candidates becomes urgent. β-carbolines alkaloids are good since a wide range biological activity these...
O presente estudo teve como objetivo extrair e avaliar o potencial antimicrobiano citotóxico de frações ricas em alcaloides obtidas a partir das partes aéreas Mitracarpus frigidus. isolamento foi realizado por meio extração ácido-base cromatografia coluna com Sephadex LH-20 fase estacionária. A atividade antimicrobiana avaliada pelo método microdiluição caldo para determinação da concentração inibitório mínima (CIM) também parâmetros quantitativos antimicrobianos (atividade total, percentual...
Este presente estudo teve como objetivo investigar o potencial antimicrobiano, leishmanicida e citotóxico do extrato em diclorometano das partes aéreas de Mitracarpus frigidus. Além identificar as principais classes metabólitos especiais desse extrato. Para realização dos ensaios biológicos foram testadas nove linhagens microrganismos (Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella typhimurium, Shigella sonnei, Klebsiella pneumoniae, Escherichia coli, Bacillus cereus, Candida...
Introdução: A incidência de microrganismos resistentes a terapias convencionais desperta necessidade no desenvolvimento novos antimicrobianos. Além disso, o dano celular gerado em decorrência da produção radicais livres na presença patógenos também configura um fator importante para busca compostos bioativos. Objetivo: Avaliar as atividades antioxidante e antimicrobiana dos extratos etanólicos das folhas Bactris gasipaes Kunth (BGFoEt), Manicaria saccifera Gaertn. (MSFoEt), frutos raízes...
Plantago major L. (Plantaginaceae) é uma planta utilizada no tratamento de feridas e tosse devido ao seu potencial anti-inflamatório, cicatrizante antimicrobiano. Visando o emprego da na formulação produtos para uso oral, objetivo deste estudo foi avaliar a atividade antimicrobiana desta espécie in vitro. Extratos etanólico hidroalcoólico, preparados com partes aéreas P. major, foram submetidos à triagem fitoquímica análise cromatografia em camada delgada (CCD). A dos extratos tintura...
Afim de investigar os fitoconstituintes Jatropha multifida L. no processo cicatrização feridas, foram avaliados extratos orgânicos e aquosos da presente espécie. O extrato hexânico folhas (MMFH) foi obtido por maceração avaliado cromatografia com fase gasosa acoplada à espectrometria massas o aquoso (MMFA)foi infusão alta eficiência ao fotoarranjo diodo. MMFH demostrou a presença alcanos, ésteres, tocoferois, esteroides triterpenos, enquanto que MMFA apresentou arilpropanoides flavonoides....