A5075527765- Phytochemistry Medicinal Plant Applications
- Essential Oils and Antimicrobial Activity
- Antifungal resistance and susceptibility
- Traditional and Medicinal Uses of Annonaceae
- Bacterial biofilms and quorum sensing
- Phytochemicals and Antioxidant Activities
- Natural product bioactivities and synthesis
- Fungal Infections and Studies
- Ethnobotanical and Medicinal Plants Studies
- Piperaceae Chemical and Biological Studies
- Phytochemistry and Biological Activities
- Complementary and Alternative Medicine Studies
- Medicinal Plant Research
- Nail Diseases and Treatments
- Plant Pathogens and Fungal Diseases
- Herbal Medicine Research Studies
- Morinda citrifolia extract uses
- Agricultural and Food Sciences
- Antimicrobial Resistance in Staphylococcus
- Cocoa and Sweet Potato Agronomy
- Research on Leishmaniasis Studies
- Phytochemicals and Medicinal Plants
- Plant-derived Lignans Synthesis and Bioactivity
- Nanocomposite Films for Food Packaging
- Sphingolipid Metabolism and Signaling
Universidade Federal de Juiz de Fora
2017-2025
Centro de Ensino Superior de Juiz de Fora
2022
Universidade Federal do Pará
1999
Candida tropicalis is one the most relevant biofilm-forming fungal species increasingly associated with invasive mucosal candidiasis worldwide. The amplified antifungal resistance supports necessity for more effective and less toxic treatment, including use of plant-derived natural products. Scopoletin, a coumarin, has shown properties against plant yeast pathogens. However, activity this coumarin clinically such as C. remains to be established. Here, we investigated potential mechanisms...
Psychorubrin, a natural pyranonaphthoquinone found in different plants, has become an interesting compound the search for new antimicrobial therapeutic agents. Here, we investigated potential antagonistic activity of psychorubrin against planktonic and biofilm bacteria. First, was tested several Gram-positive Gram-negative bacteria strains by broth microdilution susceptibility method. Second, bacterial killing assay, abundance, membrane viability were evaluated. The nucleotide leakage assay...
Staphylococcus aureus is a bacterium found on the skin and mucous membranes of humans animals. This micro-organism classified as an opportunistic pathogen causes infections in both hospital community settings. The increase antibiotic resistance, especially methicillin-resistant S. (MRSA), major challenge for clinical epidemiological practice. present study aims to investigate potential antibacterial antibiofilm activities compound [Fe(cyclam)sal]PF6 against drug-resistant strains aureus....
Ursolic acid (UA) is a pentacyclic triterpenoid known for its wide range of biological activities, including anticancer and antimicrobial effects. However, poor solubility in water limits therapeutic potential. Therefore, this work aims to evaluate the physicochemical properties ursolic acid/β-cyclodextrin inclusion complex (UA/βCD IC) investigate enhancement vitro antitumor antibacterial activities UA when complexed with βCD. Molecular docking simulation showed that carbonyl group binds...
Vulvovaginal candidiasis (VVC) is characterized by inflammatory changes in the vaginal mucosa caused abnormal colonization of Candida species. Traditional topical therapies using reference antifungal drugs usually present several issues and limitations for VVC treatment. Thus, interest new formulations, mainly those based on compounds from natural origin, has been growing over last years. Methanolic extract plant species Mitracarpus frigidus (Willd. Ex Reem Schult.) K. Schum (MFM) presented...
Spilanthol is a bioactive alkylamide from the native Amazon plant species, Acmella oleracea. However, antifungal activities of spilanthol and its application to therapeutic treatment candidiasis remain be explored. This study sought evaluate in vitro vivo activity previously isolated A. oleracea (spilanthol(AcO)) against Candida albicans ATCC® 10231™, multidrug-resistant fungal strain. Microdilution methods were used determine inhibitory fungicidal concentrations spilanthol(AcO). In...
Centrosema coriaceum Benth belongs to Fabaceae family and have few studies of biological activity chemical composition. Thus, the aims this work were determine profile ethanolic extract C. leaves (CCE) by UFLC-QTOF-MS evaluate its in vitro potential. CCE showed MIC value 1000 µg/mL against Candida glabrata (fungistatic effect) high affinity cell envelope increasing permeability nucleotide leakage, sorbitol ergosterol assays. antioxidant all assays performed. For anti-inflammatory...
In recent years, natural products with biological activities have been increasingly researched. The elucidation of phytoconstituents is necessary for the development drugs as a alternative treatment various diseases. work aimed to evaluate in vitro and silico bioactivities hexane (CCHE) methanol (CCME) fractions ethanolic extract from Centrosema coriaceum Benth (Fabaceae) leaves elucidate their phytoconstituents. CCHE CCME showed antifungal activity Candida glabrata (MIC 1000 μg/mL)...
Evaluation of the in-vivo anti-inflammatory activity methanolic extract obtained from aerial parts Mitracarpus frigidus (MFM) in infection caused by two Salmonella strains and its chemical fingerprint UFLC-quadrupole time flight-MS.The efficacy MFM was investigated a classical mouse model. A reference strain (ATCC 13311) clinical isolate were used to infect mice then orally administered during 14 days. At end treatment with MFM, inflammatory levels assayed.MFM showed significant reduction...
This study aimed to evaluate the potential of aqueous extract from Mitracarpus frigidus aerial parts (MFAq) in treatment inflammation and oxidative stress, as well characterize its chemical constituents.Total phenolic flavonoid contents were determined, phytoconstituents detected by ultra-fast liquid chromatography/quadrupole-time-of-flight tandem mass spectrometry (UFLC-QTOF-MS). The antioxidant activity was evaluated DPPH, TAC β-carotene/linoleic acid assays. In-vitro anti-inflammatory...
Abstract New strategies that enable fast and accurate visualization of Candida biofilms are necessary to better study their structure response antifungals agents. Here, we applied whole slide imaging (WSI) biofilm formation species. Three relevant biofilm-forming species ( C. albicans ATCC 10231 , glabrata 2001, tropicalis 750) were cultivated on glass coverslips both in presence absence widely used antifungals. Accumulated stained with fluorescent markers scanned bright-field fluorescence...