A5042469095- Alzheimer's disease research and treatments
- Biochemical effects in animals
- Antioxidants, Aging, Portulaca oleracea
- Cholinesterase and Neurodegenerative Diseases
- Advanced Glycation End Products research
- Diabetes Treatment and Management
- Neurological Disorders and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Diet, Metabolism, and Disease
- Neurological disorders and treatments
- Hydrogen's biological and therapeutic effects
- Neuroinflammation and Neurodegeneration Mechanisms
- Natural Antidiabetic Agents Studies
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Regulation of Appetite and Obesity
- Neuropeptides and Animal Physiology
- Biochemical Analysis and Sensing Techniques
- Inflammatory Biomarkers in Disease Prognosis
- Lymphoma Diagnosis and Treatment
- Medicinal Plants and Bioactive Compounds
- Neuroscience and Neuropharmacology Research
- Vitamin C and Antioxidants Research
- Muscle activation and electromyography studies
- Pancreatic function and diabetes
University of Zagreb
2014-2025
Institute of Public Health Osijek-Baranja County
2022
Community Health Center
2022
AimTo determine the prognostic value of baseline red blood cell distribution width (RDW) in diffuse large B lymphoma (DLBCL) patients.MethodsData from 81 DLBCL patients diagnosed 2006 to 2013 at University Hospital Center Osijek, Croatia, were reviewed. We evaluated disease outcome, overall survival (OS) and event-free (EFS), demographic, clinical laboratory factors affecting outcome. Univariate analysis Cox regression used.ResultsMedian age was 64 years, 29 men (35.8%). Higher RDW levels...
Alzheimer's disease (AD) is the most common neurodegenerative disorder with majority of patients classified as sporadic AD (sAD), in which etiopathogenesis remains unresolved. Though sAD argued to be a polygenic disorder, apolipoprotein E (APOE) ε4, was found three decades ago pose strongest genetic risk for sAD. Currently, only clinically approved disease-modifying drugs are aducanumab (Aduhelm) and lecanemab (Leqembi). All other treatment options purely symptomatic modest benefits....
The gastrointestinal (GI) system is affected in Alzheimer's disease (AD); however, it currently unknown whether GI alterations arise as a consequence of central nervous (CNS) pathology or play causal role the pathogenesis. mucus possible mediator dyshomeostasis neurological disorders CNS controls production and secretion via efferent arm brain-gut axis. aim was to use brain-first model sporadic AD induced by intracerebroventricular streptozotocin (STZ-icv; 3 mg/kg) dissect (i.e.,...
The gut-brain axis plays an important role in Parkinson's disease (PD) by acting as a route for vagal propagation of aggregated α-synuclein the gut-first endophenotype and mediator gastrointestinal dyshomeostasis via nigro-vagal pathway brain-first disease. One mechanism which may promote PD is regulating redox homeostasis overwhelming evidence suggests that oxidative stress key etiopathogenesis progression tract maintains organism critical barrier to environmental microbiological...
The gastrointestinal system may be involved in the etiopathogenesis of insulin-resistant brain state (IRBS) and Alzheimer’s disease (AD). Gastrointestinal hormone glucagon-like peptide-1 (GLP-1) is being explored as a potential therapy activation GLP-1 receptors (GLP-1R) exerts neuroprotection controls peripheral metabolism. Intracerebroventricular administration streptozotocin (STZ-icv) used to model IRBS dyshomeostasis seems development neuropathological changes. aim was explore (i)...
Altered adult hippocampal neurogenesis (AN) plays a role in the etiopathology of Alzheimer's disease (AD), disorder characterized by progressive loss memory and spatial orientation impairment. Diabetes is shown to be one risk factor for development sporadic form AD (sAD), which affects >95% patients. Streptozotocin intracerebroventricularily (STZ icv) treated rats, develop an insulin-resistant brain state learning deficits preceding amyloid beta tau pathology, may act as appropriate animal...
The spontaneously hypertensive rat (SHR) has been used to model changes in the central nervous system associated with cognitive-related disorders. Recent human and animal studies indicate a possible relationship between cognitive deficits, insulin resistance hypertension. We aimed investigate whether cognitively impaired SHRs develop and/or peripheral how their performance is influenced by animal's sex age as well strains for comparison (Wistar Wistar-Kyoto/WKY).Three seven-month-old SHR,...
Introduction: Gastrointestinal dyshomeostasis is investigated in the context of metabolic dysfunction, systemic, and neuroinflammation Alzheimer’s disease. Dysfunctional gastrointestinal redox homeostasis brain-gut incretin axis have been reported rat model insulin-resistant brain state-driven neurodegeneration induced by intracerebroventricular streptozotocin (STZ-icv). We aimed to assess whether (i) structural epithelial changes accompany duodenal oxidative stress; (ii) glucose-dependent...
Galactose, a ubiquitous monosaccharide with incompletely understood physiology is often exploited for inducing oxidative-stress mediated aging in animals. Recent research demonstrates that galactose can conserve cellular function during periods of starvation and prevent/alleviate cognitive deficits rat model sporadic Alzheimer's disease. The present aim to examine the acute effects oral on redox regulatory network (RRN).Rat plasma hippocampal RRNs are analyzed upon orogastric gavage (200 mg...
Recent evidence suggests that the gut plays a vital role in development and progression of Alzheimer's disease (AD) by triggering systemic inflammation oxidative stress. The well-established rat model AD, induced intracerebroventricular administration streptozotocin (STZ-icv), provides valuable insights into GI implications neurodegeneration. Notably, this leads to pathophysiological changes gut, including redox dyshomeostasis, resulting from central neuropathology. Our study aimed...
We propose a rapid, simple, and robust method for measurement of the reductive capacity liquid solid biological samples based on potassium permanganate reduction followed by trapping manganese dioxide precipitate nitrocellulose membrane. Moreover, we discuss how redox permanganometry (NRP) can be used high-throughput analysis present HistoNRP, its modification detailed spatial distribution in tissue with preserved anatomical relations. NRP is cost-effective, simple assessment compatible...