A5014187299- Pharmacological Effects and Toxicity Studies
- Pharmacological Receptor Mechanisms and Effects
- COVID-19 Clinical Research Studies
- Renal Transplantation Outcomes and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Epilepsy research and treatment
- Drug Transport and Resistance Mechanisms
- Atrial Fibrillation Management and Outcomes
- HIV/AIDS drug development and treatment
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Venous Thromboembolism Diagnosis and Management
- Orthopaedic implants and arthroplasty
- Pancreatitis Pathology and Treatment
- Restless Legs Syndrome Research
- Biochemical and Molecular Research
- Viral gastroenteritis research and epidemiology
- Pneumonia and Respiratory Infections
- TGF-β signaling in diseases
- Acute Myocardial Infarction Research
- Long-Term Effects of COVID-19
- Hip disorders and treatments
- Schizophrenia research and treatment
- Complementary and Alternative Medicine Studies
- Inflammatory Biomarkers in Disease Prognosis
- Orthopedic Infections and Treatments
University of Zagreb
2016-2025
University School
2007-2023
University Hospital Centre Zagreb
2022
University Hospital Dubrava
2022
Agency for Medicinal Products and Medical Devices of Croatia
2022
Zagreb School of Business
2016-2017
Whilst the association between dementia and poorer health-related quality of life (Hr-QoL) in Parkinson's disease (PD) has been well established, we aimed to explore relationship cognitive performance Hr-QoL PD without dementia. Consecutive patients (n = 124, 54% men, age 60.4 +/- 10.3 years) judged as non-demented based on DSM-IV criteria Mini Mental State Examination, free other neurodegenerative diseases or psychotic difficulties antipsychotic/antidepressive/anxyolitic treatment were...
Background Postoperatively shed blood salvage is commonly used to reduce allogenic transfusion in patients undergoing total hip ( THA ) and knee arthroplasty TKA ). Autologous retransfusion not devoid of risk. We hypothesized that adding tranexamic acid TXA a restrictive protocol would the need for postoperative autologous primary arthroplasty. Study Design Methods Ninety‐eight adult or were randomly assigned receive an intraoperative intravenous loading dose 1.0 g followed by another 1.0‐g...
Abstract We examined and compared the relationship between religiosity symptom severity in patients with major depressive disorder (MDD) rated by Hamilton Depression Rating Scale) schizophrenia (rated Positive Negative Syndrome Scale). The Duke University Religion Index, Santa Clara Strength of Religious Faith (SCSORF) questionnaire, Brief Coping scale scores were similar MDD ( n = 50) 50). In MDD, higher organizational religious activity (ORA) (estimate 2.28, 95% confidence interval [CI]...
Background: Patients with inflammatory bowel disease (IBD) to be treated thiopurines should undergo preemptive genotyping for reduced-function thiopurine methyltransferase ( TPMT ) polymorphisms. Therapeutic drug monitoring (TDM) is recommended in cases of toxicity or a lack efficacy. The relationship between genotype and 6-thioguanine nucleotide (6-TGN) 6-methylmercaptopurine (6-MMP) concentrations the early steady state was assessed. Methods: Consecutive adults IBD azathioprine underwent...
Reduced peripheral serotonin (5HT) in mice lacking tryptophan hydroxylase (TPH1), the rate limiting enzyme for 5HT synthesis, was reported to be anabolic skeleton. However, other studies TPH1 deletion either had no bone effect or an age dependent inhibition of osteoclastic resorption. The role therefore remains poorly understood. To address this issue, we used selective breeding create rat sublines with constitutively high (high-5HT) and low (low-5HT) platelet level (PSL) uptake (PSU)....
The spontaneously hypertensive rat (SHR) has been used to model changes in the central nervous system associated with cognitive-related disorders. Recent human and animal studies indicate a possible relationship between cognitive deficits, insulin resistance hypertension. We aimed investigate whether cognitively impaired SHRs develop and/or peripheral how their performance is influenced by animal's sex age as well strains for comparison (Wistar Wistar-Kyoto/WKY).Three seven-month-old SHR,...
To investigate the impact of glucuronidation enzyme (UGT1A4*3 142T>G, UGT1A4*2 70C>A, UGT2B7 -161C>T) and transporter (MDR1/ABCB1 1236C>T, ABCG2 421C>A) polymorphisms on steady-state disposition lamotrigine lamotrigine-valproate interaction.Adults with epilepsy monotherapy (n = 131) or + valproate treatment 74) were genotyped morning troughs determined as a part routine therapeutic drug monitoring.No effect UGT MDR1/ABCB1 was observed. In entire cohort, 421A allele had no however an...
Assessment of quality life (QoL) has become an important measure in Parkinson's disease (PD) healthcare as a part the efforts to evaluate ‘total burden’ illness, and not only motor disabilities. By analogy with some other diseases, we aimed investigate potential urban–rural disparities QoL PD patients. A total 111 consecutive patients were assessed for using specific 39‐item version questionnaire (PDQ‐39) cross‐sectional study involving two centers Croatia. Rural setting (adjustment center,...
To assess serum uric acid (SUA) levels determined on admission as a potential predictor of short-term mortality and long-term survival in acute myocardial infarction (AMI) patients.Data for this retrospective prognostic study were drawn from the patient database Varazdin County General Hospital Varazdin, Croatia. We included consecutive patients with verified AMI admitted within 48 hours since symptom onset during period between 1 January 1996 31 December 2001. Long-term survival/mortality...
Background: Reports on effects of advancing medical education health anxiety are scarce and contradictory.Aim: To evaluate a hypothesis that its components could be differently affected.Method: A cross-sectional study assessed the Health Anxiety Questionnaire (HAQ), Anxious Thoughts Inventory, Somatosensory Amplification Scale scores in (n = 214) law (controls, n 821) students at different years.Results: In controls, all outcomes minimally differed across study-year levels. Medical were...
The anatomy of the frontal sinus is highly variable and its variations affect occurrence/course pathological processes. We investigated size relationship to orbit, searching for patterns that would allow it be classified anatomically. Cone beam computed tomography was applied 91 skulls (age range 21–86 years) determine height, width, length, length contact with orbit in coronal sagittal planes. In addition, orbital roof pneumatization plane categorized as: none; only medial part pneumatized;...