A5021429430- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Peptidase Inhibition and Analysis
- Catalytic Cross-Coupling Reactions
- Urban and Rural Development Challenges
- Protein Structure and Dynamics
- Smart Parking Systems Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Innovative Microfluidic and Catalytic Techniques Innovation
- Catalytic Alkyne Reactions
- Cyclopropane Reaction Mechanisms
- Neuroendocrine Tumor Research Advances
- Urban Design and Spatial Analysis
- Computational Drug Discovery Methods
- Diabetes Treatment and Management
- Galectins and Cancer Biology
University of Manchester
2024
Manchester Academic Health Science Centre
2024
Age UK
2024
University of Liverpool
2022
Enantioselective cyclopropanation of α-carbonyl sulfoxonium ylides (SY) has so far been limited to addition/ring closure reactions on electron-poor olefins. Herein, we report the iridium-catalyzed intramolecular SY in presence a chiral diene up 96% yield and 98% enantioselectivity. Moreover, density functional theory calculations suggest that re face olefin preferably attacks an iridium carbene intermediate asynchronous concerted step is independent geometry olefin.
1. The disposition of anagliptin, an orally active, highly selective dipeptidyl peptidase-4 inhibitor, was investigated after a single oral dose 100 mg/1.92 MBq [14C]anagliptin to six healthy men. Almost all the (98.2%) recovered within 168 h: 73.2% in urine and 25.0% faeces.2. Anagliptin rapidly absorbed, with peak plasma concentrations unchanged drug attained at mean time 1.8-h postdose. Mean fraction absorbed >73%. Unchanged carboxylate metabolite (M1) were major components plasma,...
Virtual screening of large chemical libraries is essential to support computer-aided drug development, providing a rapid and low-cost approach for further experimental validation. However, existing computational packages are often specialised users or platform limited. Previously, we developed VSpipe, an open-source semi-automated pipeline structure-based virtual screening. We have now improved expanded the initial command-line version into interactive graphical user interface: VSpipe-GUI,...
Endoplasmic reticulum aminopeptidase 1 (ERAP1) cleaves the N-terminal amino acids of peptides, which can then bind onto major histocompatibility class I (MHC-I) molecules for presentation cell surface, driving activation adaptive immune responses. In cancer, overtrimming mature antigenic peptides reduce cytotoxic T-cell responses, and ERAP1 generate self-antigenic contribute to autoimmune cellular Therefore, modulation activity has potential therapeutic indications cancer immunotherapy in...