A5052641573- Cyclopropane Reaction Mechanisms
- Organoboron and organosilicon chemistry
- Catalytic C–H Functionalization Methods
- Asymmetric Hydrogenation and Catalysis
- Chemical Synthesis and Analysis
- Catalytic Alkyne Reactions
- Catalytic Cross-Coupling Reactions
- Synthesis and Catalytic Reactions
University of Liverpool
2022-2023
Centre National de la Recherche Scientifique
2022
École Nationale Supérieure de Chimie de Montpellier
2022
Université de Montpellier
2022
Enantioselective cyclopropanation of α-carbonyl sulfoxonium ylides (SY) has so far been limited to addition/ring closure reactions on electron-poor olefins. Herein, we report the iridium-catalyzed intramolecular SY in presence a chiral diene up 96% yield and 98% enantioselectivity. Moreover, density functional theory calculations suggest that re face olefin preferably attacks an iridium carbene intermediate asynchronous concerted step is independent geometry olefin.
Abstract The study of the reactivity cyclic sulfoxonium ylides has been so far neglected, in particular for reactions that forms carbon‐carbon bond at ylide carbon atom. Herein, we describe synthesis by palladium‐catalyzed intramolecular arylation and these C3‐alkylation indoles presence either an acid catalyst or iridium catalyst. This revealed catalysis is only efficient which tether a six‐membered lactone, whereas was better suited to reaction five‐membered ring ketone lactone. observed...
A method to reduce aldimines through hydrosilylation is reported. The catalytic system involves calcium triflimide (Ca(NTf2)2) and potassium hexafluorophosphate (KPF6) which have been shown act in a synergistic manner. expected amines are obtained fair very high yields (40-99%) under mild conditions (room temperature most cases). To illustrate the potential of this method, bioactive molecule with antifungal properties was prepared on gram scale yield environmentally friendly...