A5081149709- T-cell and B-cell Immunology
- NF-κB Signaling Pathways
- Genomics and Chromatin Dynamics
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Calcium signaling and nucleotide metabolism
- RNA and protein synthesis mechanisms
- Geochemistry and Geologic Mapping
- Phosphodiesterase function and regulation
- Machine Learning in Bioinformatics
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- Chromosomal and Genetic Variations
- Single-cell and spatial transcriptomics
- Neonatal Health and Biochemistry
- vaccines and immunoinformatics approaches
- interferon and immune responses
- Immune Response and Inflammation
- Hydrocarbon exploration and reservoir analysis
- Inflammasome and immune disorders
- Genetics, Bioinformatics, and Biomedical Research
- Atmospheric and Environmental Gas Dynamics
- Ion Channels and Receptors
- Biomedical Ethics and Regulation
Boston Children's Hospital
2022-2025
Howard Hughes Medical Institute
2022-2025
Harvard University
2022-2025
Institute of Biophysics
2012-2020
Chinese Academy of Sciences
2011-2020
FoxP3 is an essential transcription factor (TF) for immunologic homeostasis, but how it utilizes the common forkhead DNA-binding domain (DBD) to perform its unique function remains poorly understood. We here demonstrated that unlike other known TFs, formed a head-to-head dimer using linker (Runx1-binding region [RBR]) preceding domain. Head-to-head dimerization conferred distinct specificity and created docking site cofactor Runx1. RBR was also important proper folding of domain, as...
Abstract NOD-like receptors (NLRs) localize in the cytosol to recognize intracellular pathogen products and initialize innate immune response. However, ligands ligand specificity of many NLRs remain unclear. One such NLR, NLRP6, plays an important role maintaining intestinal homeostasis protecting against various diseases as colitis tumorigenesis. Here, we show that major component outer membrane gram-negative bacteria, lipopolysaccharide (LPS), binds NLRP6 directly induces global...
FOXP3 is a transcription factor that essential for the development of regulatory T cells, branch cells suppress excessive inflammation and autoimmunity
As a highly versatile intracellular signal, calcium (Ca 2+ ) regulates many different cellular processes in both animal and plant systems.Disruption of Ca homeostasis contributes to several human diseases.Owing the importance signalling, its research is now an active field life science.There are numerous signalling systems, consisting diverse array units that deliver signals with spatial temporal properties [1,2], playing roles ubiquitous biological including gene regulation, fuel...
Microsatellites are essential genomic components increasingly linked to transcriptional regulation. FoxP3, a transcription factor critical for regulatory T cell (Treg) development, recognizes TTTG repeat microsatellites by forming multimers along DNA. However, FoxP3 also binds broader range of TnG repeats (n=2-5), often at the edges accessible chromatin regions. This raises questions about how adapts sequence variability and potential role nucleosomes. Using cryo-electron microscopy...
FoxP3 is a transcription factor (TF) essential for development of regulatory T cells (Tregs), branch that suppress excessive inflammation and autoimmunity 1-5 . Molecular mechanisms FoxP3, however, remain elusive. We here show utilizes the Forkhead domain--a DNA binding domain (DBD) commonly thought to function as monomer or dimer--to form higher-order multimer upon n G repeat microsatellites. A cryo-electron microscopy structure in complex with 3 repeats reveals ladder-like architecture,...
Abstract FoxP3 is an essential transcription factor (TF) for immunologic homeostasis, but how it utilizes the common forkhead DNA-binding domain (DBD) to perform its unique function remains poorly understood. We here demonstrate that, unlike other known TFs, forms a head-to-head dimer using linker (Runx1-binding region, RBR) preceding domain. Head-to-head dimerization confers distinct specificity and creates docking site cofactor Runx1. RBR also important proper folding of domain, as...