A5002467711- Heavy metals in environment
- Heavy Metal Exposure and Toxicity
- Arsenic contamination and mitigation
- Air Quality and Health Impacts
- Environmental Toxicology and Ecotoxicology
- Mine drainage and remediation techniques
- Environmental Justice and Health Disparities
- Nanoparticles: synthesis and applications
- Indoor Air Quality and Microbial Exposure
- Mercury impact and mitigation studies
- Healthcare and Environmental Waste Management
- Radioactivity and Radon Measurements
- Toxic Organic Pollutants Impact
- Contact Dermatitis and Allergies
- Gut microbiota and health
- Electrochemical Analysis and Applications
- Pesticide Exposure and Toxicity
- Chromium effects and bioremediation
- Geochemistry and Geologic Mapping
- Per- and polyfluoroalkyl substances research
- Occupational Therapy Practice and Research
- Chemical Safety and Risk Management
- Environmental and Social Impact Assessments
- Coal and Its By-products
- Occupational exposure and asthma
Environmental Protection Agency
2016-2025
Research Triangle Park Foundation
2015-2024
Battelle
2007-2009
Pacific Northwest National Laboratory
2007
United States Department of Housing and Urban Development
2007
QuanTech (United States)
2007
The Ohio State University
2004
Oklahoma State University
2003
Speciation analysis is essential when evaluating risks from arsenic (As) exposure. In an oral exposure scenario, the importance of presystemic metabolism by gut microorganisms has been evidenced with in vivo animal models and vitro experiments microbiota. However, it unclear whether human microbiota display similar As metabolism, especially present a contaminated matrix.We evaluated metabolic potency cultured colon toward inorganic (iAs) As-contaminated soils.A microbial community was...
Assessment of soil arsenic (As) bioavailability may profoundly affect the extent remediation required at contaminated sites by improving human exposure estimates. Because small adjustments in As estimates can significantly alter risk assessments and goals, convenient, rapid, reliable, inexpensive tools are needed to determine bioavailability.We evaluated methods for assessing as a means improve potentially reduce costs.Nine soils from residential affected mining or smelting activity two...
Objective: The objective of this study was to establish a national relative moldiness index for homes in the United States. Methods: As part Housing and Urban Development's American Healthy Homes Survey, dust samples were collected by vacuuming 2 m2 bedrooms plus living rooms from nationally representative 1096 States using Mitest sampler. Five milligrams sieved (300 μm pore, nylon mesh) analyzed mold-specific quantitative polymerase chain reaction 36 indicator species samples. Results: On...
The U.S. Department of Housing and Urban Development in collaboration with the United States Environmental Protection Agency conducted a survey measuring lead, allergens, insecticides randomly selected nationally representative sample residential homes. Multistage sampling clustering was used to select 1131 homes which subset 500 included collection hard surface floor wipes. Samples were collected by trained field technicians between June 2005 March 2006 using isopropanol wetted analyzed for...
Soil properties are important factors modifying metal bioavailability to ecological receptors. Twenty-one soils with a wide range of soil (USA; http://soils.usda.gov/technical/classification/taxonomy/) were amended single concentration Pb (2,000 mg/kg) determine the effects on and toxicity earthworms. Earthworm mortality ranged from 0 100% acute following exposure same total in field soils. Internal concentrations earthworms 28.7 782 mg/kg, mean 271 mg/kg. Path analysis was used partition...
To evaluate the capabilities of in vitro assays to predict arsenic (As) relative bioavailability (RBA), we examined relationship between As bioaccessibility, determined using a number bioaccessibility (IVBA) methodologies (SBRC, IVG, PBET, DIN and UBM) RBA mouse assay for nine As-contaminated soils 1 NIST reference material (2710a). Significant differences (P < 0.05) IVBA were observed within indicating that different may not produce congruent data, as result variability extracting medium...
Human oral exposure to copper oxide nanoparticles (NPs) may occur following ingestion, hand-to-mouth activity, or mucociliary transport inhalation. This study assessed the cytotoxicity of Cupric (II) (CuO) and Cu2O-polyvinylpyrrolidone (PVP) coated NPs ions in rat (intestine epithelial cells; IEC-6) human intestinal cells, two- three-dimensional models, respectively. The effect pretreatment CuO with simulated gastrointestinal (GI) fluids on IEC-6 cell was also investigated. Both dose-...
Significance As a strategy to stabilize soil Pb, we evaluated the effect of PLJ formation on bioavailability Pb. Our technology for resulted in >90% incorporation Pb into mineral structure jarosite. This conversion decreased greater than 90%, even after pH neutralization revitalize agronomic health. may be more effective remediation method other treatment technologies and reduce removal clean-up efforts costs. Because jarosite can sequester both cationic anionic contaminants, it arsenic...
Soils are common sources of metal(loid) contaminant exposure globally. Lead (Pb) and arsenic (As) paramount concern due to detrimental neurological carcinogenic health effects, respectively. Pb and/or As contaminated soils require remediation, typically leading excavation, a costly environmentally damaging practice removing soil central location (e.g., hazardous landfill) that may not be viable option in low-income countries. Chemical remediation techniques allow for situ conversion...
Most people in the United States have been exposed to per- and polyfluoroalkyl substances (PFAS) which linked a wide array of adverse health conditions adults children. The consumption contaminated drinking water is an important human exposure pathway PFAS. Residential sources also contribute PFAS through dermal contact ingestion house dust, acts as aggregate chemicals from like furnishing materials consumer products. U.S. Department Housing Urban Development (HUD) conducted first nationwide...
Abstract Background Lead (Pb) in house dust contributes significantly to blood lead levels (BLLs) children which may result dire health consequences. Assessment of Pb the United States, relationships with soil and paint, residential factors influencing concentrations are essential probing drivers exposure. Objective vacuum-collected characterized across 346 homes participating American Health Homes Survey II (AHHS II), a US survey (2018–2019) evaluating hazards. Connections between Pb, paint...
Residential lead (Pb) exposure is of critical concern to families globally as Pb promotes severe neurological effects in children, especially those less than 5 years old, and no blood level deemed safe by the US Center for Disease Control. House dust soils are commonly thought be important sources exposure. Probing relationship between house soil understanding residential exposure, bioavailability highly influenced and/or species. We investigated paired collected from homes built before 1978...
Humans experience widespread exposure to anthropogenic per- and polyfluoroalkyl substances (PFAS) through various media, which can lead a wide range of negative health impacts. Tap water is an important source in communities with any degree contamination but routine or large-scale PFAS monitoring often depends on targeted analytical methods limited measuring specific PFAS. We analyzed 680 tap samples from the American Healthy Homes Survey II for using non-targeted analysis (NTA) expand...
In vitro bioaccessibility (IVBA) assays estimate arsenic (As) relative bioavailability (RBA) in contaminated soils to improve accuracy human exposure assessments. Previous studies correlating soil As IVBA with RBA have been limited by the use of few types and sources As, predictive value has not validated using an independent set As-contaminated soils. this study, a robust linear model was developed predict mice IVBA, capability independently unique Forty varying type contaminant source were...
Effects of different treatments on the bioavailability lead (Pb) in soil from a smelter emission contaminated site Joplin, Missouri, were evaluated mouse model. Similar estimates relative for Pb untreated or treated obtained mice and well-established juvenile swine In model, that used phosphate (phosphoric acid triple superphosphate) combined with iron oxide biosolids compost significantly reduced bioavailability. Notably, effects these remediation procedures persistent, given up to 16 years...
Several investigations have been conducted to develop in vitro bioaccessibility (IVBA) assays that reliably predict vivo oral relative bioavailability (RBA) of arsenic (As). This study describes a meta-regression model relating soil As RBA and IVBA is based upon data combined from previous examined the relationship between when was determined using an extraction 0.4 M glycine at pH 1.5. Data used included paired estimates for 83 soils various types sites such as mining, smelting, pesticide...
House dust and soils can be major sources of lead (Pb) exposure for children. The American Healthy Homes Survey (AHHS) was developed to estimate Pb from house soil, in addition other potential household contaminants allergens. We have combined X-ray absorption spectroscopic (XAS) fingerprinting