A5066314356- Mitochondrial Function and Pathology
- interferon and immune responses
- GDF15 and Related Biomarkers
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Thermal Regulation in Medicine
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA modifications and cancer
- Retinal Development and Disorders
- Visual perception and processing mechanisms
- Neural dynamics and brain function
- ATP Synthase and ATPases Research
- Long-Term Effects of COVID-19
- Nutrition and Health in Aging
- Frailty in Older Adults
University of Southern California
2020-2024
Southern California University for Professional Studies
2020
University of Washington
2020
Abstract SARS-CoV-2 induces a muted innate immune response compared to other respiratory viruses. Mitochondrial dynamics might partially mediate this effect of on immunity. Polypeptides encoded by open reading frames SARS-CoV and have been shown localize mitochondria disrupt Antiviral Signaling (MAVS) protein signaling. Therefore, we hypothesized that would distinctly regulate the mitochondrial transcriptome. We analyzed multiple publicly available RNASeq data derived from primary cells,...
Abstract SARS-CoV-2 has challenged global healthcare systems in part because its clinical manifestations are heterogeneous. Variable symptoms of could be attributed to the virus’ ability mildly induce an innate immune response, as prior transcriptomic data suggested. Mitochondrial dynamics might partially mediate effect on immunity. Many proteins encoded by SARS-CoV have been shown localize mitochondria and inhibit Antiviral Signaling protein (MAVS). We analyzed multiple publicly available...
Recent advancements in genomic, transcriptomic, proteomic, and metabolomic techniques have prompted fresh inquiry the field of aging. Here, we outline application these context mitochondrial genome suggest their potential for use exploring biological mechanisms aging immune system.