A5011413042- Automotive and Human Injury Biomechanics
- Elasticity and Material Modeling
- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Injury Epidemiology and Prevention
- Traffic and Road Safety
KU Leuven
2020-2021
The regional dynamic mechanical properties of mouse, rat, pig, and human brain tissue were compared directly in this first-of-its-kind study. Our results suggest the use pig or mouse as suitable surrogates to characterise tissue. importance work is highlighted by extensive constitutive data from animal traumatic injury research absence without any direct evidence supporting their use. Indentation force-relaxation experiments performed on brains at 10/s strain rate up 35% determine Finite...
Controlled cortical impact (CCI) on porcine brain is often utilized to investigate the pathophysiology and functional outcome of focal traumatic injury (TBI), such as cerebral contusion (CC). Using a finite element (FE) model brain, localized strain rate resulting from CCI can be computed compared experimentally assessed lesion. This way, tissue-level metrics corresponding thresholds specific for CC established. However, variability uncertainty associated with experimental parameters...
Objective Cerebral contusions (CC) represent a frequent lesion in traumatic brain injury, with potential morbidity from mass effect and tissue loss. Better understanding of the mechanical etiology will help to improve head protection. The goal this study is investigate threshold for impact parameters induce CC an vivo porcine controlled cortical model.Methods Thirty-four adult male pigs underwent craniotomy hemispherical tip on intact dura under general anesthesia. Peak depth varied between...