A5060235916- Elasticity and Material Modeling
- Automotive and Human Injury Biomechanics
- Surgical Sutures and Adhesives
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced machining processes and optimization
- Cellular and Composite Structures
- Medical Imaging and Analysis
- Advanced Surface Polishing Techniques
- Traumatic Brain Injury Research
- Connective tissue disorders research
- Cellular Mechanics and Interactions
- Orthopedic Infections and Treatments
- Bone Tissue Engineering Materials
- Elasticity and Wave Propagation
- Coronary Interventions and Diagnostics
- Total Knee Arthroplasty Outcomes
- Hip and Femur Fractures
- Spinal Fractures and Fixation Techniques
- Soft Robotics and Applications
- High-Velocity Impact and Material Behavior
- Spinal Cord Injury Research
- Foot and Ankle Surgery
- Trauma Management and Diagnosis
- 3D Printing in Biomedical Research
- Material Science and Thermodynamics
University College Dublin
2015-2024
Dublin City University
2020-2024
Google (United States)
2018
Abstract Traumatic brain injuries, the leading cause of death and disability in children young adults, are result a rapid acceleration or impact head. In recent years, global effort to better understand biomechanics TBI has been undertaken, with many laboratories creating detailed computational models head brain. For these produce realistic results they require accurate regional constitutive data for tissue. However, there large differences mechanical properties reported literature. These...
Abstract The brain is a complex organ made up of many different functional and structural regions consisting types cells such as neurons glia, well anatomical geometries. It hypothesized that the exhibit significantly mechanical properties, which may be attributed to diversity anisotropy neuronal fibers within individual regions. regional dynamic properties P56 mouse tissue in vitro situ at velocities 0.71–4.28 mm/s, deformation 70 μm are presented discussed context traumatic injury....
This study involved the simulation of five real-world head impact events in rugby, to assess level protection provided by a novel foam headguard, N-Pro. The University College Dublin Brain Trauma Model (UCDBTM) was used estimate peak resultant accelerations and brain tissue responses different scenarios. input kinematics were obtained from two sources: video analysis events, real-time data through instrumented mouthguards. simulated under both unprotected protected conditions. All...
The regional dynamic mechanical properties of mouse, rat, pig, and human brain tissue were compared directly in this first-of-its-kind study. Our results suggest the use pig or mouse as suitable surrogates to characterise tissue. importance work is highlighted by extensive constitutive data from animal traumatic injury research absence without any direct evidence supporting their use. Indentation force-relaxation experiments performed on brains at 10/s strain rate up 35% determine Finite...
Finite element (FE) brain models have revolutionised research on the biomechanics of traumatic injury (TBI). The accuracy and reliability results arising from depend equally their geometric as quality material properties used to describe mechanical behaviour brain. However, much literature human tissues' been performed at low strain rates strains. This is particularly striking considering a large portion tissue characterisation presented with motivation understanding during TBI which occurs...
The worldwide incidence of traumatic brain injuries (TBIs) is on the rise. Helmets are one best technologies available to prevent TBIs from impacts head during recreational and occupational activities. most commonly used material for helmet liners expanded polystyrene (EPS) foam. However, while EPS can reduce linear accelerations impacts, it does not perform as well at reducing rotational which considered be harmful tissue. Recently, prismatic lattice structures have shown promise in these...
The application of mechanical stimulation on bone tissue engineering constructs aims to mimic the native dynamic nature bone. Although many attempts have been made evaluate effect applied stimuli osteogenic differentiation, conditions that govern this process not yet fully explored. In study, pre-osteoblastic cells were seeded PLLA/PCL/PHBV (90/5/5 wt.%) polymeric blend scaffolds. subjected every day cyclic uniaxial compression for 40 min at a displacement 400 μm, using three frequency...
Indentation is a primary tool in the investigation of mechanical properties very soft tissue such as brain. However, usual material characterization protocols are not applicable because resulting deformation inhomogeneous, with even identification amount strain ambiguous and uncertain. Focusing on spherical indentation only, standard needed to quantify terms probe radius displacement so that different experiments can be compared contrasted. It shown here minimum axial value Eulerian...
Modelling transversely isotropic materials in finite strain problems is a complex task biomechanics, and usually addressed by using element (FE) simulations. The standard method developed to account for the quasi-incompressible nature of soft tissues decompose energy function (SEF) into volumetric deviatoric parts. However, this decomposition only valid fully incompressible materials, its use slightly compressible yields an unphysical response during simulation hydrostatic...
Abstract Vertebral compression fractures are one of the most severe clinical consequences osteoporosis and common fragility fracture afflicting 570 1070 out 100,000 men women worldwide, respectively. Vertebroplasty (VP), a minimally invasive surgical procedure that involves percutaneous injection bone cement, is efficacious methods to stabilise osteoporotic vertebral fractures. However, postoperative has been observed in up 30% patients following VP. Therefore, this study aims investigate...
Traumatic spinal cord injuries result from high impact forces acting on the spine and are proceeded by an extensive secondary inflammatory response resulting in motor, sensory, autonomic dysfunction. Experimental vivo traumatic rodents using a contusion model have been extremely useful elucidating underlying pathophysiology of these injuries. However, relationship between biomechanical factors is still not well understood. Therefore, aim this research to provide comprehensive analysis...
The cerebral meninges, made up of the dura, arachnoid, and pia mater, is a tri-layer membrane that surrounds brain spinal cord has an important function in protecting from injury. Understanding its mechanical behavior to ensure accuracy finite element (FE) head model simulations which are commonly used study traumatic injury (TBI). Mechanical characterization freshly excised porcine dura-arachnoid mater (DAM) was achieved using uniaxial tensile testing bulge inflation testing, highlighting...
The occurrence of periprosthetic femoral fractures (PFF) has increased in people with osteoporosis due to decreased bone density, poor quality, and stress shielding from prosthetic implants. PFF treatment the elderly is a genuine concern for orthopaedic surgeons as no effective solution currently exists. Therefore, goal this study was determine whether design novel advanced medicinal therapeutic device (AMTD) manufactured polymeric blend combination fracture fixation plate femur capable...
In order to avoid the numerical difficulties in locally enforcing incompressibility constraint using displacement formulation of Finite Element Method, slight compressibility is typically assumed when simulating mechanical response arterial tissue. The current standard method accounting for hyperelastic soft tissue assumes an additive decomposition strain-energy function into a volumetric and deviatoric part. This has been shown, however, be inconsistent with linear theory results cubes...
Total ankle arthroplasty is the gold standard surgical treatment for severe arthritis and fracture. However, revision surgeries due to
Mechanical characterization experiments of brain tissue are performed to understand the mechanical behavior during normal physiology and pathophysiological processes including traumatic injury. Normal, healthy, undamaged, unfixed specimens required for these ensure properties being measured not from damaged/diseased which may lead inaccurate unreliable results regarding healthy undamaged tissue. The process excising cranial vault mouse cadavers can induce lacerations in that affect its...