A5003329408- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Memory and Neural Mechanisms
- MicroRNA in disease regulation
- Tryptophan and brain disorders
- Vitamin D Research Studies
- Regulation of Appetite and Obesity
- Axon Guidance and Neuronal Signaling
- RNA and protein synthesis mechanisms
- Nerve injury and regeneration
- Metabolism and Genetic Disorders
- Heavy Metal Exposure and Toxicity
- Neurotransmitter Receptor Influence on Behavior
- Pain Mechanisms and Treatments
- Neurogenetic and Muscular Disorders Research
- Circadian rhythm and melatonin
- Biochemical effects in animals
- Metalloenzymes and iron-sulfur proteins
- Neuropeptides and Animal Physiology
- Adipokines, Inflammation, and Metabolic Diseases
- Quality and Safety in Healthcare
- Fibroblast Growth Factor Research
- Endoplasmic Reticulum Stress and Disease
University of Tartu
2013-2025
Abstract The effects of developmental lead exposure on the emotional reactivity, contextual fear conditioning and neurogenesis in dentate gyrus 60–80 days‐old rats were studied. Wistar rat pups exposed to 0.2% acetate via their dams’ drinking water from postnatal day (PND) 1 PND 21 directly weaning until 30. At 60 80 level anxiety studied, respectively. all animals received injections BrdU determine Pb generation new cells hippocampus survival differentiation patterns. results present study...
Obesity is an emerging health problem worldwide as it associated with increased risk of cardiovascular, metabolic, mental disorders, and cancer. Therapeutic weight management remains one the options for treatment excess comorbidities. In this study, therapeutic potential elocalcitol, a fluorinated derivative vitamin D, was studied on model high-fat diet (HFD)-induced obesity in mice. It demonstrated that co-administration elocalcitol doses 15 ug/kg (i.p.) twice week 16 weeks prevented body...
The global decline in the number of physician-scientists, despite an increase practicing physicians, underscores a critical need for integrating research training into medical education. Addressing this issue, we established international exchange program between University Tartu (UT) and Iceland (UI). This initiative aimed to enhance scientific literacy, foster transferable skills, align curricula with European standards through collaborative experiences. enabled reciprocal student...
Abstract The neural cell adhesion molecule (NCAM) plays a pivotal role in brain plasticity. Brain plasticity itself has crucial the development of depression. aim this study was to analyze whether NCAM‐deficient (NCAM −/− ) mice exhibit depression‐like behaviour and peptide termed FGL, derived from NCAM binding site for fibroblast growth factor (FGF) receptor, is able reverse signs mice. Our showed that demonstrated increased freezing time tail‐suspension test reduced preference sucrose...
Alzheimer's disease (AD) is a neurodegenerative disorder with no cure. Limited treatment options available today do not offer solutions to slow or stop any of the suspected causes. The current medications used for symptomatic AD include memantine and acetylcholine esterase inhibitors. Some studies suggest that melatonin could also be in patients due its sleep-improving properties.In this study, we evaluated whether combination melatonin, administered 32 days drinking water, was more...
Abstract Vitamin D deficiency is a worldwide health concern, especially in the elderly population. Much remains unknown about relationship between vitamin (VDD), stress‐induced cognitive dysfunctions and depressive‐like behaviour. In this study, 4‐month‐old male C57Bl/6J mice were fed with control or free diet for 6 months, followed by unpredictable chronic stress (UCMS) 8 weeks. VDD induced impairment reduced grooming behaviour, but did not induce While UCMS sufficient expected phenotype...
The miR-146 family consists of two microRNAs (miRNAs), miR-146a and miR-146b, which are both known to suppress a variety immune responses. Here in this study, we show that miR-146b is abundantly expressed neuronal cells, while mainly microglia astroglia adult mice. Accordingly, deficient (Mir146b-/-) mice exhibited anxiety-like behaviors enhanced cognition. Characterization cellular composition Mir146b-/- using flow cytometry revealed an increased number neurons decreased abundancy the...
Background: Individual differences in behavioural traits influence susceptibility to addictive disorders. Drug addiction involves changes gene expression, proposed occur via DNA methylation (DNAm). Aims: To investigate DNAm reward-related brain structures (nucleus accumbens (NAc), lateral habenula (LHb)) response cocaine exposure rats differing spontaneous exploratory activity. Methods: Rats were observed the exploration box and categorised as high- (HE) or low explorers (LE). administered...
The miR-146 family consists of two microRNAs (miRNAs), miR-146a and miR-146b (miR-146a/b), both which are known to suppress immune responses in a variety conditions. Here, we studied how constitutive deficiency ( Mir146b-/- ) affects lipopolysaccharide (LPS)-induced neuroinflammation mice. Our experiments demonstrated that results the attenuation LPS-induced neuroinflammation, as it was evidenced by reduction sickness behavior, decrease inflammatory status microglia, loss morphological signs...
AIM: To investigate the impact of polysialylated neural cell adhesion molecule (PSA-NCAM) on survival retinal ganglion cells (RGCs) in experimentally induced diabetes mice. METHODS: Diabetes was 2.5 months old Swiss Webster mice by intraperitoneal injection streptozotocin (STZ, 90 mg/kg) once daily for two consecutive days. Examination proteins interest retinas from diabetic at 2mo after induction performed using immunohistochemistry and Western blot analysis. RGCs were counted wholemounted...
MicroRNAs (miRNAs) play crucial roles in regulating inflammation and cellular senescence. Among them, miR-146a has emerged as a key modulator of inflammation, but its role obesity-induced senescence remains unexplored. This study investigates the involvement high-fat diet (HFD)-induced hypothalamic protective effects elocalcitol (Elo), non-hypercalcemic, fluorinated vitamin D analog on HFD-induced Wild-type (WT) HFD-fed mice exhibited increased body weight, impaired locomotor activity,...
Wolfram syndrome (WS) is a rare condition caused by homozygous or compound heterozygous mutations in the WFS1 gene primarily. It diagnosed on basis of early-onset diabetes mellitus and optic nerve atrophy. Patients complain trigeminal-like migraines show deficits vibration sensation, but underlying cause unknown. Using accurate cell models two separate, rodent WS that excellent face construct validity, here we have examined trigeminus, sensation sensory neuronal function WS. Analysis ex vivo...