A5006059250- Heat shock proteins research
- Hemoglobinopathies and Related Disorders
- Macrophage Migration Inhibitory Factor
- CRISPR and Genetic Engineering
- Natural product bioactivities and synthesis
- HER2/EGFR in Cancer Research
- Phytochemical Studies and Bioactivities
- Nuclear Receptors and Signaling
- TGF-β signaling in diseases
- Plant biochemistry and biosynthesis
- Cancer Cells and Metastasis
- FOXO transcription factor regulation
- Nutrition and Health in Aging
- Epigenetics and DNA Methylation
- Cell Adhesion Molecules Research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Apelin-related biomedical research
- GDF15 and Related Biomarkers
Yenepoya University
2021-2025
Ex vivo cellular system that accurately replicates sickle cell disease and β-thalassemia characteristics is a highly sought-after goal in the field of erythroid biology. In this study, we present generation progenitor lines with mutation using CRISPR/Cas9. The models exhibit similar differentiation profiles, globin expression proteome dynamics as patient-derived hematopoietic stem/progenitor cells. Additionally, these recapitulate pathological conditions associated both diseases. Hydroxyurea...
Lung cancer remains the leading cause of cancer-related deaths worldwide due to its poor prognosis. Despite significant advancements in understanding development, improvements diagnostic methods, and multimodal therapeutic regimens, prognosis lung has still not improved. Therefore, it is reasonable look for newer alternative medicines treatment. Bhallataka nut extract, derived from seeds
Growth differentiation factor-15 (GDF15) is a cytokine/growth factor that belongs to the Transforming growth factor-ß (TGF-ß) protein family. The expression of GDF15 low in most human organs under normal conditions. stress-responsive cytokine primarily produced by macrophages response inflammatory stimuli. altered associated with many cancers due inflammation caused disease. triggers activity through its receptor Glial-derived neurotrophic factor-family α-like (GFRAL) and mediates multiple...