André Sperl

ORCID: 0000-0001-8069-8389
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About
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Research Areas
  • Spinal Cord Injury Research
  • Pregnancy-related medical research
  • Vehicle emissions and performance
  • Mechanical Circulatory Support Devices
  • Tribology and Lubrication Engineering
  • Advanced Combustion Engine Technologies
  • Biodiesel Production and Applications
  • Trace Elements in Health
  • Neonatal Respiratory Health Research
  • Neurogenetic and Muscular Disorders Research
  • Lubricants and Their Additives
  • Trauma and Emergency Care Studies
  • Gear and Bearing Dynamics Analysis
  • Trauma Management and Diagnosis
  • Spinal Dysraphism and Malformations
  • Cardiac Arrest and Resuscitation
  • Traumatic Brain Injury Research

Heidelberg University
2016-2020

University Hospital Heidelberg
2016-2020

Oslo Sports Trauma Research Center
2020

After traumatic spinal cord injury, an acute phase triggered by trauma is followed a subacute involving inflammatory processes. We previously demonstrated that peripheral serum cytokine expression changes depend on neurological outcome after injury. In subsequent intermediate phase, repair and remodeling takes place under the mediation of growth factors such as Insulin-like Growth Factor 1 (IGF-1). IGF-1 promising factor which thought to act neuroprotective agent. Since previous findings...

10.1371/journal.pone.0159764 article EN cc-by PLoS ONE 2016-07-22

Traumatic Spinal Cord Injury (TSCI) is debilitating and often results in a loss of motor sensory function caused by an interwoven set pathological processes. Oxidative stress inflammatory processes are amongst the critical factors secondary injury phase after TSCI. The essential trace element Zinc (Zn) plays crucial role during this as part antioxidant defense system. study aims to determine dynamic patterns serum Zn concentration patients with TSCI test for correlation neurological...

10.3390/antiox9050421 article EN cc-by Antioxidants 2020-05-13

In the secondary injury phase after traumatic spinal cord (TSCI), oxidative stress and neuroinflammatory responses at site of constitute crucial factors controlling damage extent may serve as potential therapeutic targets. We determined Magnesium (Mg) serum concentration dynamics in context with neurological remission patients TSCI Mg is suspected to limit production reactive oxygen species reduce lipid peroxidation. A total 29 acute were enrolled, blood samples drawn over 3 months 11...

10.3390/antiox8110509 article EN cc-by Antioxidants 2019-10-24

Context/objective: Examining hemoglobin (Hb) dynamics with regard to the potential of neurological remission in patients traumatic spinal cord injury (TSCI).Design: Prospective Clinical Observational Study.Setting: BG Trauma Centre Ludwigshafen, Department Paraplegiology, Rhineland-Palatinate, Germany.Methods: From 2011 2017 a total 80 acute were enrolled and divided into three groups: initial impairment either (G1; n = 33) or without subsequent (G0; 35) vertebral fractures as control group...

10.1080/10790268.2019.1632060 article EN Journal of Spinal Cord Medicine 2019-06-18

INTRODUCTION: Traumatic Spinal Cord Injury (TSCI) is debilitating and often results in a loss of motor sensory function caused by an interwoven set pathological processes. Oxidative stress inflammatory processes are amongst the critical factors secondary injury phase after TSCI. The essential trace element Zinc (Zn) plays crucial role during this as part antioxidant defence system. OBJECTIVE: To determine dynamic patterns serum Zn concentration patients with TSCI test for correlation to...

10.2139/ssrn.3572840 article EN SSRN Electronic Journal 2020-01-01

10.4271/2005-01-4132 article EN SAE technical papers on CD-ROM/SAE technical paper series 2005-11-22
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