A5080704497- Spinal Cord Injury Research
- Bone fractures and treatments
- Orthopedic Surgery and Rehabilitation
- Elbow and Forearm Trauma Treatment
- Pregnancy-related medical research
- Spinal Dysraphism and Malformations
- Spinal Fractures and Fixation Techniques
- Shoulder Injury and Treatment
- Biomedical and Chemical Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Nerve Injury and Rehabilitation
- Orthopaedic implants and arthroplasty
- Periodontal Regeneration and Treatments
- Pressure Ulcer Prevention and Management
- Cardiovascular Issues in Pregnancy
- Trauma Management and Diagnosis
- Wound Healing and Treatments
- Traumatic Brain Injury Research
- Trace Elements in Health
- Bee Products Chemical Analysis
- Diabetic Foot Ulcer Assessment and Management
- Nerve injury and regeneration
- Spine and Intervertebral Disc Pathology
- Pelvic and Acetabular Injuries
- TGF-β signaling in diseases
Klinikum Ludwigshafen
2012-2025
Berufsgenossenschaftliche Unfallklinik Ludwigshafen
2006-2019
Linnaeus University
2018
Heidelberg University
2009-2016
Ludwigshafen University of Business and Society
2016
Islamic Azad University, Tehran
2016
University of Kurdistan
2016
Marymount University
2015
University Hospital Heidelberg
2012
Heidelberg University
2009
Methods Between 2005 and 2012, 50 patients (23 female, 27 male) with nonunion of the humeral shaft were included in this retrospective study. The mean age was 51.3 years (14 to 88). had a 1.5 prior operations (sd 1.2;1 8). All assessed according specific risk score order devise an optimal individual therapy plan consistent Diamond Concept. In 32 cases (64%), change osteosynthesis angular stable locking compression plate performed. According additional bone graft and/or morphogenetic...
Pro- and anti-inflammatory cytokines might have a large impact on the secondary phase neurological outcome of patients with acute spinal cord injury (SCI). We measured serum levels different (Interferon-γ, Tumor Necrosis Factor-α, Interleukin-1β, IL-6, IL-8, IL-10, Vascular Endothelial Growth Factor) over 12-week period in 40 traumatic SCI patients: at admission average one hour after initial trauma; four, nine, 12, 24 h; Three, seven days admission; two, eight, twelve weeks admission. This...
In recent years, the treatment of wounds with honey has received an increasing amount attention from healthcare professionals in Germany and Austria. We conducted a prospective observational multicentre study using Medihoney™ dressings 10 hospitals – nine one Wound‐associated parameters were monitored systematically at least three times all patients. Data derived 121 various aetiologies over period 2 years analysed. Almost half patients younger than 18 old, 32% population was oncology...
Background: Comminuted radial head fractures are often associated with secondary injuries and elbow instability.Objectives: The aim of this retrospective study was to evaluate how well the modular metallic implant EVOLVE® prosthesis restores functional range motion (ROM) stability in acute care.Patients Methods: Eighty-five patients comminuted received treatment an between May 2001 November 2009.Seventy-five were available for follow-up.On average, followed 41.5 months (33.0: 4.0...
Background/Objectives: Traumatic spinal cord injury (TSCI) profoundly impacts patients by precipitating a loss of motor and sensory capabilities, largely due to oxidative stress inflammation during the secondary phase. Methods: This investigation explores diagnostic potential zinc (Zn) free (fZn) as biomarkers analyzing their serum concentration dynamics in 48 TSCI individuals with TSCI, aim correlating these levels neurological impairment. Serum samples collected at admission, 4 h, 9 12 24...
Neuroinflammation presumably has an important impact on the secondary phase of spinal cord injury and is regulated by pro- anti-inflammatory cytokines. We analyzed serum levels three different cytokines (insulin-like-growth-factor [IGF]-1, tumor growth factor [TGF]-β1, soluble CD 95 ligand [sCD95L]), in blood samples 23 patients admitted with acute traumatic between November 2010 July 2013 a follow-up period 12 weeks. Quantification was performed using Human Quantikine Immunoassays,...
After traumatic spinal cord injury, an acute phase triggered by trauma is followed a subacute involving inflammatory processes. We previously demonstrated that peripheral serum cytokine expression changes depend on neurological outcome after injury. In subsequent intermediate phase, repair and remodeling takes place under the mediation of growth factors such as Insulin-like Growth Factor 1 (IGF-1). IGF-1 promising factor which thought to act neuroprotective agent. Since previous findings...
The use of low intensity pulsed ultrasound (LIPUS) in the treatment nonunions is still controversial. present study concerned with whether this procedure has a clinical and which cofactors influence its therapeutic results. In prospective, single institution, observational study, data from October 2010 to 2013 61 60 patients treated EXOGEN® LIPUS therapy were analysed. average age was 45.4 ± 9.81 (18–63) years. Treatment primarily done on long bones lower extremity (75.4 %). All examined...
Abstract: The local application of bone morphogenetic protein-7 (BMP-7) in combination with the transplantation autologous graft improves outcome nonunion treatment; however, specific reasons remain unclear. In this study, we sought to determine if BMP-7 contributes improved regeneration therapy by modulation angiogenic and inflammable cytokine expression patterns early inflammation response. Therefore, utilized analysis serological patterns. As a matched pair analysis, best-fitting patients...
Background: The proper timing for surgery in patients with acute spinal cord injury is controversial. This study was conducted to detect if there an advantage early (within the first 4 hours after trauma) compared late (between and 24 on neurological outcome. Methods: In this single institution prospective cohort study, data were analyzed from 51 injured average age of 43.4 (±19.2) years. influence (29 within hours) as opposed (22 between decompression evaluated by comparing Patients...
Traumatic Spinal Cord Injury (TSCI) is debilitating and often results in a loss of motor sensory function caused by an interwoven set pathological processes. Oxidative stress inflammatory processes are amongst the critical factors secondary injury phase after TSCI. The essential trace element Zinc (Zn) plays crucial role during this as part antioxidant defense system. study aims to determine dynamic patterns serum Zn concentration patients with TSCI test for correlation neurological...