A5049438524- Trace Elements in Health
- Heavy Metal Exposure and Toxicity
- Aluminum toxicity and tolerance in plants and animals
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Iron Metabolism and Disorders
- Selenium in Biological Systems
- Metal-Organic Frameworks: Synthesis and Applications
- Insect Utilization and Effects
- Drug Transport and Resistance Mechanisms
- Plant Micronutrient Interactions and Effects
- Covalent Organic Framework Applications
- Agriculture Sustainability and Environmental Impact
- Nutritional Studies and Diet
- Force Microscopy Techniques and Applications
- Boron Compounds in Chemistry
- Infant Nutrition and Health
- Molecular Sensors and Ion Detection
- Spinal Fractures and Fixation Techniques
- Silk-based biomaterials and applications
- Proteins in Food Systems
- Viral Infections and Immunology Research
- Spinal Cord Injury Research
- Phytase and its Applications
- Food Chemistry and Fat Analysis
Technische Universität Berlin
2016-2025
Leibniz-Institute for Food Systems Biology at the Technical University of Munich
2019-2024
University of Potsdam
2024
Federal Institute for Risk Assessment
2022
In-Q-Tel
2018
Fraunhofer Institute for Production Systems and Design Technology
2018
Selenium homeostasis depends on hepatic biosynthesis of selenoprotein P (SELENOP) and SELENOP-mediated transport from the liver to e.g. brain. In addition, maintains copper homeostasis. metabolism are inversely regulated, as increasing decreasing selenium levels observed in blood during aging inflammation. Here we show that treatment increased intracellular SELENOP hepatocytes decreased extracellular levels. Hepatic accumulation is a characteristic Wilson's disease. Accordingly, were low...
Trace elements such as zinc, manganese, copper, or iron are essential for a wide range of physiological functions. It is therefore crucial to ensure an adequate supply these the body. Many previous investigations have dealt with role transport proteins, in particular their selectivity for, and competition between, different ions. Another so far less well investigated major factor influencing absorption trace seems be intestinal mucus layer. This gel-like substance covers entire...
Free zinc is considered to be the exchangeable and biological active form of in serum, discussed a suitable biomarker for alterations body homeostasis related diseases. Given that coronavirus disease 2019 (COVID-19) characterized by marked decrease total serum zinc, clinical data indicate status impacts susceptibility severity infection, we hypothesized free might altered response SARS-CoV-2 infection may reflect severity. To test this hypothesis, concentrations samples survivors...
Plant-based diets usually contain more nutrient-dense foods such as vegetables, legumes, whole grains, and fruits than a standard Western diet. Yet, the amount especially bioavailability of several nutrients, trace elements, is supposed to be lower in comparison with consumption animal-derived foods. Based on this, Nutritional Evaluation (NuEva) study (172 participants) was initiated compare element status omnivores, flexitarians, vegetarians, vegans. Serum selenium, zinc, copper...
Background/Objectives: Traumatic spinal cord injury (TSCI) profoundly impacts patients by precipitating a loss of motor and sensory capabilities, largely due to oxidative stress inflammation during the secondary phase. Methods: This investigation explores diagnostic potential zinc (Zn) free (fZn) as biomarkers analyzing their serum concentration dynamics in 48 TSCI individuals with TSCI, aim correlating these levels neurological impairment. Serum samples collected at admission, 4 h, 9 12 24...
Approximately 1 billion people worldwide suffer from zinc deficiency, with severe consequences for their well-being, such as critically impaired intestinal health. In addition to an extreme degeneration of the epithelium, mucus is seriously disturbed in zinc-deficient (ZD) animals. The underlying cellular processes well relevance mucin-producing goblet cells, however, remain unknown. To this end, study examines impact deficiency on synthesis, production, and secretion mucins homeostasis...
The investigation of luminal factors influencing zinc availability and accessibility in the intestine is great interest when analyzing parameters regulating intestinal resorption. Of note, mucins were suggested to play a beneficial role zinc. Their exact binding properties, however, remain unknown impact these glycoproteins on human resorption has not been investigated detail. Thus, aim this study elucidate uptake into enterocytes its transfer blood. In present study, vitro properties...
Abstract A new family of porous metal–organic frameworks (MOFs), namely alkali phosphonate MOFs, is reported. [Na 2 Cu(H 4 TPPA)] ⋅ (NH (CH 3 ) ( GTUB‐1 was synthesized using the tetratopic 5,10,15,20‐tetrakis[ p ‐phenylphosphonic acid] porphyrin H 8 ‐TPPA linker with planar X‐shaped geometrical core. composed rectangular void channels BET surface area 697 m g −1 . exhibits exceptional thermal stability. The toxicity analysis indicates that it well tolerated by an intestinal cell line,...
Background Zinc (Zn) is an essential trace element with high relevance for the immune system, and its deficiency associated elevated infection risk severe disease course. The association of Zn status response to SARS-CoV-2 vaccination unknown. Methods A cohort adult health care workers (n=126) received two doses BNT162B2, provided up four serum samples over a time course 6 months. Total IgG neutralizing antibody potency was determined, along total as well free concentrations. Results...
Abstract Labile copper(II) ions (Cu 2+ ) in serum are considered to be readily available for cellular uptake and constitute the biologically active Cu species blood. It might also suitable reflect copper dyshomeostasis during diseases such as Wilson’s disease (WD) or neurological disorders. So far, no direct quantification method has been described determine this small subset. This study introduces a fluorometric high throughput assay using novel binding fluoresceine-peptide sensor FP4 (Kd...
This study explores age- and time-dependent variations in postprandial micronutrient absorption after a micronutrient-rich intervention meal within the Biomiel (bioavailability of micronutrients elderly) study. Comprising 43 healthy participants, compares young (n = 21; mean age 26.90 years) old 22; 66.77 men women, analyzing baseline concentrations six-hour dynamics iron (Fe), copper (Cu), zinc (Zn), selenium (Se), iodine (I), free (fZn), vitamin C, retinol, lycopene, β-carotene,...
The essential trace element copper is relevant for many important physiological processes. Changes in homeostasis can result from disease and affect human health. A reliable assessment of status by suitable biomarkers may enable fast detection subtle changes metabolism. To this end, additional besides serum ceruloplasmin (CP) concentrations are required. aim study was to investigate the emerging CP oxidase (CPO) activity, exchangeable (CuEXC) labile healthy women compare them with...
ABSTRACT Polyphosphate (polyP) is an intriguing molecule that found in almost any organism, covering a multitude of cellular functions. In industry, polyP used due to its unique physiochemical properties, including pH buffering, water binding, and bacteriostatic activities. Despite the importance polyP, analytics still challenging, with gold standard being 31 P NMR. Here, we present simple staining method using fluorescent dye JC‐D7 for semi‐quantitative evaluation yeast extracts. Notably,...
Mucins, the main component of mucus secretions goblet and epithelial cells, are known for exhibiting a different behaviour in accordance with their surrounding environment (i.e. among others environmental pH), which induces drastic change measured mechanical properties. In this work, we have first employed Atomic Force Microscopy (AFM) Spectroscopy mode to evaluate adhesion porcine mucin films at nanoscale, changes caused particular factor by pH variation between 7.0 4.0, both quite common...
The molecular mechanisms of intestinal zinc resorption and its regulation are still topics ongoing research.
Evolution of metal–organophosphonates from macrocycles into cages.
In order to address human zinc deficiency, fortifying staple foods with is a safe and cost-effective solution. To ensure the nutritional properties quality of final product, tolerance microorganisms involved in fermentation necessary. Bread, which widely consumed, occupies substantial place many people’s diets, often based on sourdough making process; thus, it might be an important headlining product. This study investigated yeasts lactic acid bacteria that are specifically suited produce...
The industrial production of Tenebrio molitor L. requires optimized rearing and processing conditions to generate insect biomass with high nutritional value in large quantities. One the problems arising from is a tremendous loss mineral accessibility, affecting, amongst others, essential trace element Zn. As feasible strategy this study investigates Zn-enrichment mealworms during meet requirements for humans animals. Following feeding ZnSO4-spiked wheat bran substrates late instar mealworm...
Phytochemicals like pyrrolizidine alkaloids (PAs) can affect the health of humans and animals. PAs occur for example in tea, honey or herbs. Some are known to be cytotoxic, genotoxic, carcinogenic. Upon intake high amounts, hepatotoxic pneumotoxic effects were observed humans. This study aims elucidate different toxicokinetic parameters uptake their metabolism with vitro models. We examined transport rates differently structured (monoester, open-chained diester, cyclic diester) over a model...