A5089838441- Polymer Surface Interaction Studies
- RNA Interference and Gene Delivery
- Neuroscience and Neural Engineering
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Lipid Membrane Structure and Behavior
- Virus-based gene therapy research
- Photoreceptor and optogenetics research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Neonatal and fetal brain pathology
- Bone Tissue Engineering Materials
- Graphene and Nanomaterials Applications
- Polymer Nanocomposite Synthesis and Irradiation
- Advanced Drug Delivery Systems
- Characterization and Applications of Magnetic Nanoparticles
- Children's Physical and Motor Development
- Carbon Nanotubes in Composites
- Skin and Cellular Biology Research
- Aortic aneurysm repair treatments
- Dendrimers and Hyperbranched Polymers
- Multilingual Education and Policy
- Nanofabrication and Lithography Techniques
- Micro and Nano Robotics
- Advanced Sensor and Energy Harvesting Materials
The University of Texas at San Antonio
2019-2025
Universidad de Los Andes
2022-2025
University of Pittsburgh
2024
University of California, Irvine
2021-2022
Tecnológico de Monterrey
2018
CIC biomaGUNE
2009-2016
Massachusetts Institute of Technology
2014-2016
Universidad Americana de Morelos
2016
Universidad Veracruzana
2016
University of Illinois Urbana-Champaign
2016
Exciting nerve cells deep inside the brain Current techniques to stimulate regions need a permanently implanted wire or an optical fiber. Working in mice, Chen et al. developed method overcome this problem (see Perspective by Temel and Jahanshahi). They introduced heat-sensitive capsaicin receptors into then injected magnetic nanoparticles specific regions. The could be heated external alternating fields, which activated ion channel–expressing neurons. Thus, cellular signaling can controlled...
We demonstrate arrays of opioid biosensors based on chemical vapor deposition grown molybdenum disulfide (MoS2) field effect transistors (FETs) coupled to a computationally redesigned, water-soluble variant the μ-opioid receptor (MOR). By transferring dense films monolayer MoS2 crystals onto prefabricated electrode arrays, we obtain high-quality FETs with clean surfaces that allow for reproducible protein attachment. The fabrication yield and exceeds 95%, an average mobility 2.0 cm2 V–1 s–1...
Abstract Cancer is a dynamic disease characterized by its heterogeneous nature. This heterogeneity results in critical problems that interfere with the eradication of cancer tumors such as multidrug resistance, drug efflux capacity, narrow therapeutic window, and undesired side effects. Nanomedicine has introduced new platforms for delivery to enhance efficiency anticancer drugs. In addition delivery, nanocarriers liposomes, carbon nanotubes, quantum dots, polymeric nanoparticles,...
Hysteretic heat dissipation by magnetic nanoparticles (MNPs) in alternating fields (AMFs) allows these materials to act as local transducers of external stimuli. Commonly employed cancer research, MNPs have recently found applications remote control heat‐dependent cellular pathways. Here, a thermally labile linker chemistry is adapted for the release neuromodulatory compounds from surfaces via nanoscale heating. By examining range MNP sizes, and considering individual particle loss powers,...
Confocal Raman Microscopy (CRM) is used to study the cell internalization of poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) fabricated by emulsion techniques with either poly(ethylene imine) (PEI) or bovine serum albumin (BSA) as surface stabilizers. HepG2 cells were exposed PEI and BSA stabilized PLGA NPs. Spontaneous Spectra taken in one same spot showed bands arising from cellular environment well characteristic for PLGA, proving that NPs have been internalized. It was found...
Developing scaffolds supporting functional cell attachment and tissue growth is critical in basic research, engineering, regenerative medicine approaches. Though poly(ethylene glycol) (PEG) its derivatives are attractive for hydrogels scaffold fabrication, they often require bioactive modifications due to their bioinert nature. In this work, biomimetic synthesized conductive polypyrrole-poly(3,4-ethylenedioxythiophene) copolymer doped with poly(styrenesulfonate) (PPy-PEDOT:PSS) was used as a...
Introduction: Perivascular Spaces (PVS) visible on brain MRI are fluid-filled compartments surrounding cerebral blood vessels. They key indicators of small vessel disease (CSVD) and associated with mild cognitive impairment (MCI) dementia. This study aims to measure the effect PVS location severity performance in adults from a community-based population. Methods: Framingham Heart Study participants all cohorts available scans neuropsychological (NP) test data within one year each other were...
Gene editing has emerged as a therapeutic approach to manipulate the genome for killing cancer cells, protecting healthy tissues, and improving immune response tumor. The gene tool achaete-scute family bHLH transcription factor 1 CRISPR guide RNA (ASCL1-gRNA) is known restore neuronal lineage potential, promote terminal differentiation, attenuate tumorigenicity in glioblastoma tumors. Here, we fabricated polymeric nonviral carrier encapsulate ASCL1-gRNA by electrostatic interactions deliver...
Abstract The layer‐by‐layer (LbL) assembly technique was applied for the surface modification of biodegradable poly(lactide‐ co ‐glycolide) nanoparticles (NPs), employing poly(acrylic acid) (PAA), and polyethylenimine (PEI) as building blocks. Amino terminated poly(ethylene glycol) (PEG) folate decorated PEG (PEG‐FA) were grafted onto multilayers via condensation between carboxylic groups amine from or PEG‐FA. LbL covalent functionalization monitored by means ζ ‐potential measurements quartz...
Abstract The intracellular delivery of Doxorubicin (Dox) from poly(lactide‐ co ‐glycolide) (PLGA) nanoparticles stabilised with bovine serum albumin, in HepG2 cells, is studied via flow cytometry, fluorescence lifetime imaging microscopy (FLIM), confocal Raman (CRM) and cell viability studies. Flow cytometry shows that the initial uptake PLGA Dox follow same kinetics. However, following 8 h incubation, intensity cellular decreases, while case both parameters remain constant. FLIM presence a...
PEG hydrogels are routinely used in immunoprotection applications to hide foreign cells from a host immune system. Size-dependent transport is typically exploited these systems prevent access by macromolecular elements of the system while allowing low molecular weight nutrients. This work studies nanoscale hydrogel coating for improved beneficial materials across thicker coatings completely blocking undesired larger materials. Coatings composed diacrylate 575 and 3500 Da were studied...
Noninvasive manipulation of cell signaling is critical in basic neuroscience research and developing therapies for neurological disorders psychiatric conditions. Here, the wireless force-induced stimulation primary neuronal circuits through mechanotransduction mediated by magnetic microdiscs (MMDs) under applied low-intensity low-frequency alternating fields (AMFs), described. MMDs are fabricated top-down lithography techniques that allow cost-effective mass production biocompatible with...
Selective hysteretic heating of multiple collocated sets single domain magnetic nanoparticles (SDMNPs) by alternating fields (AMFs) may offer a useful tool for biomedical applications. The possibility magnetothermal multiplexing has not yet been realized, in part due to prevalent use linear response theory model SDMNP AMFs. Predictive successes dynamic hysteresis (DH), more generalized heat dissipation SDMNPs, are observed experimentally with detailed calorimetry measurements performed at...
Remotely triggered hysteretic heat dissipation by magnetic nanoparticles (MNPs) selectively attached to targeted proteins can be used break up self-assembled aggregates. This magnetothermal approach is applied the amyloid-β (Aβ) protein, which forms dense, insoluble plaques characteristic of Alzheimer's disease. Specific targeting dilute MNPs Aβ aggregates confirmed via transmission electron microscopy (TEM) and found consistent with a statistical model MNP distribution on substrates....
Minimally invasive manipulation of cell signaling is critical in basic neuroscience research and developing therapies for neurological disorders. Here, we describe a wireless chemomagnetic neuromodulation platform the on-demand control primary striatal neurons that relies on nanoscale heating events. Iron oxide magnetic nanoparticles (MNPs) are functionally coated with thermoresponsive poly (oligo (ethylene glycol) methyl ether methacrylate) (POEGMA) brushes loaded dopamine. Dopamine...
Carbon Nanotubes (CNTs) have been functionalized with a layer of poly(sulfopropyl methacrylate) (PSPM) synthesized from silane initiators attached to the CNT walls. The PSPM brush was coated poly(allyl amine hydrochloride) (PAH) and on top PAH lipid vesicles composed 75% 1,2-dioleoyl-sn-glycero-3-phosphocholine 25% 1,2-dioleoyl-sn-glycero-3-[phospho-L-serine] were assembled. surface modification CNTs assembly followed by Transmission Electron Microscopy (TEM) ζ-potential measurements. TEM...