It is a matter of ongoing debate whether newly generated granule cells contribute to epileptic activity in the hippocampus. To address this question, we investigated neurogenesis and epileptiform (EA) along hippocampal septotemporal axis intrahippocampal kainate (KA) mouse model for temporal lobe epilepsy. Multisite vivo recordings immunolabeling c-Fos showed that KA-induced status epilepticus (SE) extended both hippocampi with stronger intensity at ipsilateral contralateral sites....

Restoration of motor and sensory functions in paralyzed patients requires the development tools for simultaneous recording stimulation neural activity spinal cord. In addition to its complex neurophysiology, cord presents technical challenges stemming from flexible fibrous structure repeated elastic deformation during normal motion. To address these engineering constraints, we developed highly fiber probes, consisting entirely polymers, combined optical activity. The fabricated probes...

Abstract Due to the limited regenerative ability of neural tissue, a diverse set biochemical and biophysical cues for increasing nerve growth has been investigated, including neurotrophic factors, topography electrical stimulation. In this report, we explore optogenetic control neurite as cell-specific alternative By investigating broad range optical stimulation parameters on dorsal root ganglia (DRGs) expressing channelrhodopsin 2 (ChR2), identified conditions that enhance outgrowth by...

In neuroscience, single-shank penetrating multi-electrode arrays are standard for sequentially sampling several cortical sites with high spatial and temporal resolution, the disadvantage of neuronal damage. Non-penetrating surface grids used in electrocorticography (ECoG) permit simultaneous recording multiple sites, limited due to distance tissue, large contact size impedances. Here we compared new thin-film parylene C ECoG grids, covering guinea pig primary auditory cortex, recordings from...

Summary Purpose: Temporal lobe epilepsy is often accompanied by neuron loss and rewiring in the hippocampus. We hypothesized that interaction of subnetworks entorhinal–hippocampal loop between epileptic events should show significant signatures these pathologic changes. Methods: combined simultaneous recording local field potentials entorhinal cortex (EC) dentate gyrus (DG) freely behaving kainate‐injected mice with histologic analyses computational modeling. Key Findings: In healthy mice,...

Remotely triggered hysteretic heat dissipation by magnetic nanoparticles (MNPs) selectively attached to targeted proteins can be used break up self-assembled aggregates. This magnetothermal approach is applied the amyloid-β (Aβ) protein, which forms dense, insoluble plaques characteristic of Alzheimer's disease. Specific targeting dilute MNPs Aβ aggregates confirmed via transmission electron microscopy (TEM) and found consistent with a statistical model MNP distribution on substrates....

Mesial temporal lobe epilepsy is characterized by focal, recurrent spontaneous seizures, sclerosis and granule cell dispersion (GCD) in the hippocampal formation. Changes theta rhythm properties have been correlated with severity of restructuring were suggested as a cause memory deficits accompanying epilepsy. For severe sclerosis, it has even questioned whether band oscillations persist. We asked how change graded along longitudinal axis these changes correlate overall recorded local field...

Optogenetic modulation of neural activity is a ubiquitous tool for basic investigation brain circuits. While the majority optogenetic paradigms rely on short light pulses to evoke synchronized optically sensitized cells, many neurobiological processes are associated with slow local field potential (LFP) oscillations. Therefore, we developed hybrid fiber probe capable simultaneous electrophysiological recording and optical stimulation used it investigate utility sinusoidal evoking oscillatory...

Current developments of electrodes for neural recordings address the need biomedical research and applications high spatial acuity in electrophysiological recordings. One approach is usage novel materials to overcome electrochemical constraints state-of-the-art metal contacts. Promising are carbon nanotubes (CNTs), as they well suited interfacing. The CNTs increase effective contact surface area decrease impedances while keeping minimal diameters. However, prevent toxic dissolving CNTs, an...

Abstract Objective. Recording and stimulating neuronal activity across different brain regions requires interfacing at multiple sites using dedicated tools while tissue reactions the recording often prevent their successful long-term application. This implies technological challenge of developing complex probe geometries keeping overall footprint minimal, selecting materials compatible with neural tissue. While potential soft in reducing response is uncontested, implantation these limited to...

A major disadvantage of inhalation therapy with continuous drug delivery is the loss medication during expiration. Developing a breath-triggered release system can highly decrease this loss. However, there currently no directly inside patient interface (nasal prong) for preterm neonates available due to their high breathing frequency, short inspiration time and low tidal volume. Therefore, nasal prong an integrated valve releasing aerosol increasing inhaled efficiency desirable. We...

Precise localization of brain tissue causing severe neurological conditions requires subdural recording arrays with high electrode density and low mechanical stiffness compliant the tissue. However, most currently used − such as clinical ECoG grids are rather stiff limited in spatial resolution. To overcome these constrains a novel architecture is proposed using delocalized electronic (de)multiplexer grains. Here, their functional units described both hard‐ software, tested simulations...

This study aims to facilitate the identification of similar devices for both, European Medical Device Regulation (MDR) and US 510(k) equivalence pathway by leveraging existing data. Both are related regulatory read across chemicals, where toxicological data from a known substance is transferred one under investigation, as they aim streamline accreditation process new chemicals.

On page 6594, polymer fibers are designed by P. Anikeeva and co-workers to mimic fibrous geometry of the nerves allow simultaneous optical stimulation neural recording in spinal cord. The cover picture illustrates flexibility bifunctional probes their ability accommodate deformation due movement vertebrae.

Background: Developing new (triggered) or improving existing inhaler systems for (preterm) neonates and adults requires test benches the determination of aerosol output rate. Furthermore, real-time measurement rate is advantageous with respect to both development costs time, especially when using liquid humidified dry aerosols. The current standard procedures following ISO 27427, however, are time-consuming. Moreover, these not applicable inhalers preterm neonates, due their high breathing...

Current personalized treatment of neurological diseases is limited by availability appropriate manufacturing methods suitable for long term sensors neural electrical activities in the brain. An additive process polymer-based biocompatible chronic application towards individualized implants here presented. To thermal crosslinking polymers, developed extrusion enables, combination with an infrared (IR)-Laser, accelerated curing directly after passing outlet nozzle. As a result, no additional...

With its diversity of signaling modalities: electrical, chemical and mechanical, nervous system poses demands multimodality on neural interface technologies. Multimaterial fiber technology may enable minimally invasive multifunctional probing the complexity circuits.

On p. 2100, P. Anikeeva and co-workers demonstrate a technique using remotely triggered local heating to disaggregate deposits of the protein Aβ(1–42), which plays an important role in Alzheimer's Disease pathogenesis. The cover image shows neural network (green) overlayed with amyloid beta plaques (red) that are decorated magnetic nanoparticles (blue). glow around blue spheres represents heat dissipation by nanoparticles, induces disaggregation plaques.

We present the successful in vivo testing of a triggerable, reconfigurable neural probe designed to record activity central nervous system for extended periods time.The consists thin polyimide-gold-polyimide sandwich structure that can be deflected prior insertion store mechanical energy.After inserting into brain and waiting initial glial sheath form, device triggered, causing recording tip penetrate fresh tissue.Here we first triggering acute electrical recordings from this rodent motor...

Abstract The use of intracortical electrodes is a crucial method for medical diagnosis and treatment holds the promise overcoming various neural diseases challenges in prosthetics. general physical electrical function as well biocompatibility extensively tested before are implanted, however, their longterm performance, still limited through tissue scarring electrode deterioration, consequently decrease signal quality. To overcome this challenge, aspects such materials selection, coatings,...

Abstract Objective Recording and stimulating neuronal activity across different brain regions requires interfacing at multiple sites using dedicated tools while tissue reactions the recording often prevent their successful long-term application. This implies technological challenge of developing complex probe geometries keeping overall footprint minimal, selecting materials compatible with neural tissue. While potential soft in reducing response is uncontested, implantation these limited to...