A5015171081- Infective Endocarditis Diagnosis and Management
- Antimicrobial Resistance in Staphylococcus
- Streptococcal Infections and Treatments
- Orthopedic Infections and Treatments
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Acute Myocardial Infarction Research
- Venous Thromboembolism Diagnosis and Management
- Bacterial Identification and Susceptibility Testing
- Cardiac electrophysiology and arrhythmias
- Otolaryngology and Infectious Diseases
- Pericarditis and Cardiac Tamponade
- Palliative Care and End-of-Life Issues
- Cardiac Structural Anomalies and Repair
- Heart Rate Variability and Autonomic Control
- Hemodynamic Monitoring and Therapy
- Cardiac tumors and thrombi
- Blood Pressure and Hypertension Studies
- Cardiovascular Function and Risk Factors
- Infectious Aortic and Vascular Conditions
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Childhood Cancer Survivors' Quality of Life
- Tracheal and airway disorders
- Transplantation: Methods and Outcomes
Odense University Hospital
2014-2024
University of Copenhagen
2018
National Heart Foundation of Australia
2002
Heart Foundation
2002
Patients with infective endocarditis on the left side of heart are typically treated intravenous antibiotic agents for up to 6 weeks. Whether a shift from oral antibiotics once patient is in stable condition would result efficacy and safety similar those continued treatment unknown.
Staphylococcus aureus infective endocarditis (IE) is a critical medical condition associated with high morbidity and mortality. In the present study, we prospectively evaluated importance of screening echocardiography in an unselected S. bacteraemia (SAB) population.From 1 January 2009 to 31 August 2010, total 244 patients SAB at six Danish hospitals underwent echocardiography. The inclusion rate was 73% all eligible (n= 336), 53 included (22%; 95% CI: 17-27%) were diagnosed definite IE....
In the POET (Partial Oral Endocarditis Treatment) trial, oral step-down therapy was noninferior to full-length intravenous antibiotic administration. The aim of present study perform pharmacokinetic/pharmacodynamic analyses for treatments infective endocarditis assess probabilities target attainment (PTAs).Plasma concentrations antibiotics were measured at day 1 and 5. Minimal inhibitory (MICs) determined bacteria causing (streptococci, staphylococci, or enterococci)....
Increasing attention has been given to the risk of infective endocarditis (IE) in patients with certain blood stream infections (BSIs). Previous studies have conducted on selected patient cohorts, yet unselected data are sparse. We aimed investigate prevalence IE BSIs bacteria typically associated IE.By crosslinking nationwide registries from 2010 2017, we identified IE: Enterococcus faecalis (E. faecalis), Staphylococcus aureus (S. aureus), Streptococcus spp., and coagulase negative...
The purpose of this study was to assess the clinical importance 18F-FDG-PET/CT used in extra cardiac work-up patients with infective endocarditis (IE). IE is a serious condition significant mortality. Besides degree valvular involvement, prognosis relies crucially on presence systemic infectious embolism. Seventy-two (71% males and mean age 63 ± 17 years) were evaluated addition standard including patient history, physical examination, conventional imaging modalities, weekly...
Left ventricular aneurysms are uncommon complications of myocardial infarction. However, it is important to identify them because they associated with increased morbidity and mortality. True tend be managed conservatively whereas false aneurysms, the risk rupture, usually treated urgent surgery. Distinguishing these two subtypes therefore critical cardiovascular magnetic resonance (MR) being used more frequently characterise type aneurysm as well provide clear three-dimensional images...
Most Staphylococcus aureus isolates can cause invasive disease given the right circumstances, but it is unknown if some are more likely to severe infections than others. S. bloodstream from 120 patients with definite infective endocarditis and 121 bacteraemia without underwent whole-genome sequencing. Genome-wide association analysis was performed using a variety of bioinformatics approaches including SNP analysis, accessory genome k-mer based analysis. Core analyses found no either two...
Blood was collected on admission and after 1–2 h in 130 consecutive patients admitted with typical chest pain order to assess the capacity of myoglobin, fatty-acid-binding protein (FABP), CK-MB mass, troponin I (TnI) early identification acute myocardial infarction (AMI) without ST elevation. Using maximum value within 6 onset symptoms, AMI detected a 90–95% sensitivity 81–94% specificity by FABP at cut-off level 8–12 µg/l, or 81–86% 89–93%, respectively, myoglobin 70–90 µg/l. mass TnI had...
BackgroundDevice-related infection (DRI) is a severe complication of treatment with cardiac implantable electronic devices. Identification the causative pathogen essential for optimal treatment, but conventional methods often are inadequate.ObjectiveThe purpose this study was to improve microbiological diagnosis in DRI using sonication and next-generation sequencing analysis. The primary objective identification pathogens. secondary estimation sensitivity different detecting...
Abstract Background Linezolid in combination with rifampicin has been used treatment of infective endocarditis especially for patients infected staphylococci. Objectives Because reported to reduce the plasma concentration linezolid, present study aimed characterize population pharmacokinetics linezolid purpose quantifying an effect cotreatment. In addition, possibility compensation by dosage adjustments was evaluated. Patients and methods Pharmacokinetic measurements were performed 62...
AimsNon-device related right-sided infective endocarditis (ND-RSIE) is not well characterized. We aimed to characterize patients with (IE) emphasis on the epidemiology, clinical characteristics and complications of ND-RSIE.MethodsIn this population-based cohort study, we identified IE using ICD-10 codes from Danish National Hospital Register in Region Southern Denmark between January 2007 May 2017. records were reviewed, outcomes recorded.ResultsWe included 1243 confirmed episodes which 82%...
Pulmonary arteriovenous malformations (PAVMs) may cause recurrent brain abscess. The primary aim was to determine the prevalence of PAVM amongst survivors proportion with cardiac right-to-left shunts also assessed post hoc.
BackgroundStep-down oral antibiotic therapy is associated with a non-inferior long-term outcome compared to continued intravenous in the treatment of left-sided infective endocarditis (IE). We aimed analyze whether step-down also patients large vegetations (vegetation length ≥ 10 mm) or among undergoing surgery before therapy.MethodsWe included without presence aortic root abscess at diagnosis from POET study. Multivariable Cox regression analyses were used find associations between...
As a consequence of the demographic development with increasing proportion older people, prevalence heart failure (HF) is expected to rise considerable economic and societal costs. However, knowledge on cardiac structure function among population-based samples exceptional old lacking.Population-based study all persons (no exclusion criteria) living in western part Denmark turning 100 years year 2015. In-home face-to-face interviews were conducted, echocardiography blood sampling for plasma...
Background: Increasing attention has been given to the risk of infective endocarditis (IE) in patients with certain blood stream infections (BSI). Previous studies have conducted on selected patient cohorts, yet unselected data are sparse. We aimed investigate prevalence IE BSIs bacteria typically associated IE. Methods: By crosslinking nationwide registries from 2010-2016, we identified IE: Enterococcus faecalis (E. faecalis), Staphylococcus aureus (S. aureus), Streptococcus spp., and...