A5039953238- Cancer Risks and Factors
- Nutritional Studies and Diet
- Colorectal Cancer Screening and Detection
- Diet and metabolism studies
- Physical Activity and Health
- Childhood Cancer Survivors' Quality of Life
- Nutrition and Health in Aging
- Cancer survivorship and care
- Antioxidant Activity and Oxidative Stress
- Ovarian cancer diagnosis and treatment
- Genetic factors in colorectal cancer
- Genetic Associations and Epidemiology
- Multiple and Secondary Primary Cancers
- Esophageal Cancer Research and Treatment
- Endometrial and Cervical Cancer Treatments
- Adipose Tissue and Metabolism
- Lymphatic System and Diseases
- Gastric Cancer Management and Outcomes
- Retinoids in leukemia and cellular processes
- Muscle metabolism and nutrition
- Cancer, Lipids, and Metabolism
- Bladder and Urothelial Cancer Treatments
- Folate and B Vitamins Research
- Vitamin D Research Studies
- Metabolomics and Mass Spectrometry Studies
Imperial College London
2014-2024
Division of Cancer Epidemiology and Genetics
2024
National Cancer Institute
2024
Deutsches Diabetes-Zentrum e.V.
2017
St Mary's Hospital
2017
Background: Ultra-processed food (UPF) accounts for a majority of calories consumed in the United States, but impact on human health remains unclear. We aimed to identify poly-metabolite scores blood and urine that are predictive UPF intake. Methods findings: IDATA participants (n=718), aged 50-74 years, with serially collected up 6 24-hour dietary recalls (ASA-24s), over 12-months, were included metabolomics analysis, which used ultra-high performance liquid chromatography tandem mass...
Based on the Global Cancer Update Programme, formally known as World Research Fund/American Institute for Continuous Project, we performed systematic reviews and meta-analyses to investigate association of postdiagnosis body fatness, physical activity dietary factors with breast cancer prognosis. We searched PubMed Embase randomised controlled trials longitudinal observational studies from inception 31 October 2021. calculated summary relative risks (RRs) 95% confidence intervals (CIs) using...
Abstract Variations in serum amino acid levels are linked to a multitude of complex disorders. We report the largest genome-wide association study (GWAS) on nine acids UK Biobank participants (117 944, European descent). identified 34 genomic loci for circulatory alanine, 48 glutamine, 44 glycine, 16 histidine, 11 isoleucine, 19 leucine, 9 phenylalanine, 32 tyrosine and 20 valine. Our gene-based analysis mapped 46–293 genes associated with acids, including MIP, GLS2, SLC gene family, GCKR,...
Abstract Background The effects of habitual physical activity on physiology and disease prevention are not fully understood. We examined the associations between activity, metabolites in systemic circulation, breast cancer risk. Methods Total levels were assessed using doubly labeled water, accelerometers, previous day recalls IDATA study (N=707 participants, ages 50-74 years, 51% women). Assessments occurred 1-6 times over a 12-month period blood samples collected twice. Partial Spearman...
Familial hypercholesterolemia (FH), while highly prevalent, is a significantly underdiagnosed monogenic disorder. Improved detection could reduce the large number of cardiovascular events attributable to poor case finding. We aimed assess whether machine learning algorithms outperform clinical diagnostic criteria (signs, history, and biomarkers) recommended screening in United Kingdom identifying individuals with FH-causing variants, presenting scalable for general populations.