A5023203376- Nanoparticles: synthesis and applications
- Air Quality and Health Impacts
- Inhalation and Respiratory Drug Delivery
- Heavy Metal Exposure and Toxicity
- Aquaculture disease management and microbiota
- Aquaculture Nutrition and Growth
- Climate Change and Health Impacts
- Chemical Safety and Risk Management
- Recycling and Waste Management Techniques
- Graphene research and applications
- COVID-19 and healthcare impacts
- Graphene and Nanomaterials Applications
- Microplastics and Plastic Pollution
- Risk and Safety Analysis
- Air Quality Monitoring and Forecasting
- Advanced Battery Technologies Research
- Infection Control and Ventilation
Hoseo University
2018-2023
Korea Institute of Toxicology
2020
Recently, new approach methods (NAM) have been utilized to reduce animal experimentation and housing care costs. The use of NAM assess safety is paramount, underscoring the need for method be established validity reliability. inhalation toxicity now developing replace traditional tests. To align with studies, dosimetry dose metrics in vitro must consistent those studies. In this study, we present a novel address key elements metric characterization testing using an air-liquid interface (ALI)...
Graphene oxides possess unique physicochemical properties with important potential applications in electronics, pharmaceuticals, and medicine. However, the toxicity following inhalation exposure to graphene oxide has not yet been clarified. Therefore, this study conducted a short-term analysis using nose-only system male Sprague-Dawley rats. A total of four groups (15 rats per group) were exposed: (1) control (fresh air), (2) low concentration (0.76 ± 0.16 mg/m
Abstract Background Inhalation exposure to nanomaterials in workplaces can include a mixture of multiple nanoparticles. Such ambient nanoparticles be high dissolution or low vivo and we wished determine whether co-exposure particles with different rates affects their biokinetics. Methods Results Rats were exposed biosoluble silver (AgNPs, 10.86 nm) biopersistent gold (AuNPs, 10.82 for 28 days (6-h/day, 5-days/week 4 weeks) either separate NP inhalation exposures combined co-exposure. The NPs...
Abstract Background Toxicokinetics of nanomaterials, including studies on the absorption, distribution, metabolism, and elimination are essential in assessing their potential health effects. The fate nanomaterials after inhalation exposure to multiple is not clearly understood. Methods Male Sprague–Dawley rats were exposed similar sizes silver nanoparticles (AgNPs, 10.86 nm) gold (AuNPs, 10.82 for 28 days (6-h/day, 5-days/week four weeks) either with separate NP exposures or combined...
Lung deposition and retention measurements are now required by the newly revised OECD inhalation toxicity testing guidelines 412 413 when evaluating clearance biopersistence of poorly soluble nanomaterials, such as multi-walled carbon nanotubes (MWCNTs). However, lung concentration is challenging with certain carbon-based iron-based it difficult to differentiate them from endogenous elements. Therefore, current 28-day study investigated kinetics tangled MWCNTs. Male Sprague Dawley rats were...
A lithium-ion battery is a rechargeable that uses the reversible reduction of lithium ions to store energy and predominant type in many industrial consumer electronics. The batteries are essential ensure they operate safely. We conducted an exposure assessment five days after fire battery-testing facility. assessed some potentially hazardous materials fire. sampled total suspended particles, hydrogen fluoride, with real-time monitoring particulate matter (PM) 1, 2.5, 10 micrometers (μm)....
Abstract Background Information on particle deposition, retention, and clearance is important when evaluating the risk of inhaled nanomaterials to human health. The revised Organization Economic Cooperation Development (OECD) inhalation toxicity test guidelines now require lung burden measurements after rodent subacute sub-chronic exposure (OECD 412, OECD 413) inform behavior translocation during post-exposure observation (PEO). Lung are particularly relevant testing chemical a solid poorly...
The inhalation toxicity of carbon nanofibers (CNFs) is not clearly known due to relatively few related studies reported. An acute study and short-term (5 days) were therefore conducted using Sprague-Dawley rats. In the study, rats grouped exposed a fresh air control or low (0.238 ± 0.197), moderate (1.935 0.159), high (24.696 6.336 mg/m3) CNF concentrations for 6 h thereafter sacrificed at 14 days. For (0.593 0.019), (2.487 0.213), (10.345 0.541 h/day 5 days 1, 3, 21 post-exposure. No...