A5038641310- Chemical Analysis and Environmental Impact
- Nanoparticles: synthesis and applications
- Receptor Mechanisms and Signaling
- Water Treatment and Disinfection
- Heavy Metal Exposure and Toxicity
- Anesthesia and Neurotoxicity Research
- Carcinogens and Genotoxicity Assessment
- Nanotechnology research and applications
- Animal testing and alternatives
- Chemistry and Chemical Engineering
- Pharmaceutical and Antibiotic Environmental Impacts
- Neurotransmitter Receptor Influence on Behavior
- Analytical chemistry methods development
- Microplastics and Plastic Pollution
- Risk Perception and Management
- Environmental Chemistry and Analysis
- Chemical Safety and Risk Management
- Neuropeptides and Animal Physiology
- Pharmacological Receptor Mechanisms and Effects
- Neonatal Health and Biochemistry
- Neuroscience and Neuropharmacology Research
- Biological Stains and Phytochemicals
- Effects and risks of endocrine disrupting chemicals
- Healthcare and Environmental Waste Management
- Water Quality Monitoring and Analysis
InterScience (United States)
2000-2023
Boston University
2017
Southern Nevada Water Authority
2010
University of Nebraska Medical Center
1992-2007
Oregon Health & Science University
2002
Society of Environmental Toxicology and Chemistry
1996
Seattle University
1996
Application of a sensitive new detection method has revealed widespread perchlorate contamination groundwater in the southwestern United States, typically at 0.005-0.020 mg/L (5-20 ppb). Perchlorate is competitive inhibitor process by which iodide actively transported from bloodstream into thyroid. This inhibitory action basis its pharmaceutical use (in treatment hyperthyroidism) as well potential toxicity. To establish dose response humans for inhibition thyroidal uptake and any short-term...
Interest in the public health significance of trace levels pharmaceuticals potable water is increasing, particularly with regard to effects long-term, low-dose exposures. To assess risks and establish target concentrations for treatment, human risk-based screening 15 pharmaceutically active ingredients four metabolites were compared detected at 19 drinking treatment plants across United States. Compounds selected based on rate use, likelihood occurrence, potential toxicity. Screening...
For nanotechnology to meet its potential as a game-changing and sustainable technology, it is important ensure that the engineered nanomaterials nanoenabled products gain entry marketplace are safe effective. Tools methods needed for regulatory purposes allow rapid material categorization according human health environmental risk potential, so materials of high concern can be targeted additional scrutiny, while categories pose least receive expedited review. Using carbon nanotubes an...
There has been a conceptual shift in toxicological studies from describing what happens to explaining how the adverse outcome occurs, thereby enabling deeper and improved understanding of biomolecular mechanistic profiling can inform hazard identification improve risk assessment. Compared traditional toxicology methods, which have heavy reliance on animals, new approaches generate data are becoming available for safety assessment chemicals, including high-throughput high-content screening...
To determine, on the basis of iodide uptake inhibition (IUI), whether associations between urinary concentrations IUI agents (perchlorate, nitrate, and thiocyanate), as total perchlorate equivalent concentration (PEC), serum thyroid parameters suggest functional abnormalities. Additional hormone measures were released to augment National Health Examination Survey (NHANES) 2001 2002 data set, which we used in this study.Enhanced 2001-2002 set study. Multiple regression was assess...
This article discusses endocrine disrupting chemicals (EDCs) and pharmaceuticals that are found in municipal wastewater treatment plant effluents surface waters influenced by effluents. Sources of origination exposure, health effects on humans aquatic life, regulations, water treatment, source protection, risks, ongoing research discussed.
A lithium-ion battery is a rechargeable that uses the reversible reduction of lithium ions to store energy and predominant type in many industrial consumer electronics. The batteries are essential ensure they operate safely. We conducted an exposure assessment five days after fire battery-testing facility. assessed some potentially hazardous materials fire. sampled total suspended particles, hydrogen fluoride, with real-time monitoring particulate matter (PM) 1, 2.5, 10 micrometers (μm)....
In vitro studies showed that MK-912 ((2S, 12bS)1',3'-dimethylspiro(1,3,4,5',6,6',7,12b-octahydro -2H-benzo[b]furo[2,3-a]quinolizine)-2,4'-pyrimidin-2'-one) is a potent alpha2-adrenergic receptor antagonist with high affinity (Ki = 0.42, 0.26 and 0.03 nM to alpha2A, alpha2B alpha2C, respectively) selectivity (alpha2A/alpha1A 240; alpha2A/D-1 3600; alpha2A/D-2 3500; alpha2A/5-HT1 700; alpha2A/5-HT2 4100). The compound was labeled 11C evaluated in rodents monkey as specific radioligand for...
The OECD test guidelines for animal experiments play an important role in evaluating the chemical hazards. Animal tests performed using guidelines, especially when good laboratory practice (GLP) principle is applied, reduce duplication of toxicity testing and ensure best mutual acceptance data by OECD's Mutual Acceptance Data (MAD). inhalation 412 (28 days) 413 (90 have been revised. These now reflect inclusion nanomaterials recent scientific technological developments. In particular, these...
Studies demonstrate that with sufficient dose and duration, 1,4-dioxane (1,4-DX) induces liver tumors in laboratory rodent models. The available evidence aligns a threshold-dependent, tumor promotion mode of action (MOA). MOA key events (KE) rats are well developed but less so the mouse. Therefore, we conducted 90-day drinking water study female mice to evaluate early KE at 7, 28, 90 days. Female B6D2F1/Crl consumed containing 0, 40, 200, 600, 2000 or 6000 ppm 1,4-DX. 1,4-DX was detected...
In the opossum kidney cell line 5-hydroxytryptamine (serotonin; 5-HT)1B receptor is negatively coupled to adenylyl cyclase via a Gi protein. Preincubation of monolayers with 5-HT resulted in 5-HT1B receptor-mediated desensitization expressed as 4-fold rightward shift dose-response curve and 10 29% decrease maximal inhibition forskolin-stimulated cyclic AMP production. These moderate decreases potency efficacy were concentration- time-dependent. Maximal occurred 3 hr preincubation. caused no...
Environmental pollution, primarily from industrialization, has caused significant adverse effects to humans, animals, and the ecosystem. Attempts have been made reduce prevent these pollutants through better waste management practices. Incineration is one such practice, which seeks health impacts future generations by destroying today, without increasing risk those living near incineration facilities in process. As with any industrial process, however, proper design operation are important...