A5018714356- 3D Printing in Biomedical Research
- Cellular Mechanics and Interactions
- Hydrogels: synthesis, properties, applications
- Gut microbiota and health
- Proteoglycans and glycosaminoglycans research
- Cancer Cells and Metastasis
- Pancreatitis Pathology and Treatment
- Petroleum Processing and Analysis
- Rheology and Fluid Dynamics Studies
- Polysaccharides Composition and Applications
- Injection Molding Process and Properties
- Proteins in Food Systems
- Mathematical Biology Tumor Growth
- Innovations in Concrete and Construction Materials
- Advanced Drug Delivery Systems
- Pediatric Hepatobiliary Diseases and Treatments
- Additive Manufacturing and 3D Printing Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Electrohydrodynamics and Fluid Dynamics
- Phase Equilibria and Thermodynamics
- Angiogenesis and VEGF in Cancer
- Cell Adhesion Molecules Research
- Gallbladder and Bile Duct Disorders
Oregon State University
2019-2024
University of Michigan–Ann Arbor
2023
Design of experiments, a statistical optimization tool, was used to optimize the gelation time, compressive modulus, and stability hydrazone-crosslinked hyaluronic acid hydrogels for controlled protein delivery.
The adhesion in 3D-printed composites between dissimilar layers was investigated response to demand for multimaterial prints. Previously, we reported on the thermal properties printability of thermoplastic polyurethane (TPU) blends~\cite{harris001}. Here, report qualitative and quantitative commonly-printed materials, acrylonitrile butadiene styrene (ABS) or acrylate (ASA), flexible TPU. ASTM D1002/D3164 lap shear tests were performed measure strength plastics TPU, finding values...
Abstract Cervical cancer is the second leading cause of cancer‐related death in women under 40 and one few cancers to have an increased incidence rate decreased survival over last 10 years. One five patients will recurrent and/or distant metastatic disease these face a 5‐year less than 17%. Thus, there pressing need develop new anticancer therapeutics for this underserved patient population. However, development drugs remains challenge, as only 7% novel are approved clinical use. To...
Poly(vinyl)-alcohol – alginate beads with immobilized cells and a slow-release compound were optimized for long-term bioremediation of chlorinated solvents.
ABSTRACT Endometrial cancer is one of the most common gynecological cancers in world, with an estimated 382,000 new cases and 90,000 deaths each year. There no specific treatment, as underlying causes endometrial neoplasia are poorly understood. This study focuses on development validation a three-dimensional (3D) vitro multilayer, multicellularhydrogel that facilitates drug screening analysis. We hypothesized combination natural (collagen type I IV, fibrinogen, fibronectin, Laminin)...
To estimate yield stress and other rheological properties relevant to modeling of wax deposition in pipelines where flow is continuous, but varies across the pipe radius, model wax-oil mixtures are cooled at multiple cooling rates under constant shear until a temperature reached, which arrested by gelation due crystal formation. From these data, combined with measurement temperature-dependence precipitated concentration differential scanning calorimetry, an apparent σy, below each...
Hydrazone-crosslinked hydrogels are attractive protein delivery vehicles for regenerative medicine. However, each medicine application requires unique hydrogel properties to achieve an ideal outcome. The of a can be impacted by numerous factors involved in its fabrication. We used design experiments (DoE) statistical modeling efficiently optimize the physicochemical hyaluronic acid (HA) hydrazone-crosslinked bone regeneration. modified HA with either adipic dihydrazide (HA-ADH) or aldehyde...
OBJECTIVE To evaluate the in vitro effect of 20% N-acetylcysteine (NAC) on viscosity normal canine bile. ANIMALS Bile samples obtained from 10 adult dogs euthanized for reasons unrelated to biliary disease. PROCEDURES Each sample was centrifuged remove particulates, then divided into 3 aliquots. One aliquot remained untreated (control). other aliquots diluted 1:4 with NAC or sterile water. The all measured a rotational viscometer at 25°C. Viscosity control immediately after centrifugation...
Abstract There is a critical need for complex multicellular three-dimensional physiomimetic models of cancer that can interface with high throughput drug screening methods to assess anti-metastatic and anti-angiogenic efficacy in rapid yet content manner. We report multilayer platform human cervical cell lines primary microvascular endothelial cells incorporates biophysical extracellular matrix cues, interfaces standard methods, evaluate invasion microvessel formation over time. Through the...