A5010877371- Cancer Cells and Metastasis
- 3D Printing in Biomedical Research
- Immune cells in cancer
- Cellular Mechanics and Interactions
- Reproductive System and Pregnancy
- Cell Adhesion Molecules Research
- Endometriosis Research and Treatment
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Hydrogels: synthesis, properties, applications
- Proteoglycans and glycosaminoglycans research
- TGF-β signaling in diseases
- Cell Image Analysis Techniques
- Gut microbiota and health
- Immunotherapy and Immune Responses
- Tissue Engineering and Regenerative Medicine
- Cancer-related molecular mechanisms research
- Mathematical Biology Tumor Growth
- Angiogenesis and VEGF in Cancer
- Cancer Research and Treatments
- AI in cancer detection
- Galectins and Cancer Biology
- Innovative Microfluidic and Catalytic Techniques Innovation
- Polysaccharides Composition and Applications
- Anatomy and Medical Technology
Oregon State University
2020-2025
Oregon Health & Science University
2020-2022
University of Wisconsin–Madison
2018-2020
Corvallis Environmental Center
2020
Abstract Peritoneal metastasis of high-grade serous ovarian cancer (HGSOC) occurs when tumor cells suspended in ascites adhere to mesothelial cells. Despite the strong relationship between metastatic burden and prognosis HGSOC, there are currently no therapies specifically targeting process. We utilized a coculture model multivariate analysis examine how interactions cells, alternatively-activated macrophages (AAM) influence adhesion found that AAM-secreted MIP-1β activates CCR5/PI3K...
Design of experiments, a statistical optimization tool, was used to optimize the gelation time, compressive modulus, and stability hydrazone-crosslinked hyaluronic acid hydrogels for controlled protein delivery.
Abstract Cervical cancer is the second leading cause of cancer‐related death in women under 40 and one few cancers to have an increased incidence rate decreased survival over last 10 years. One five patients will recurrent and/or distant metastatic disease these face a 5‐year less than 17%. Thus, there pressing need develop new anticancer therapeutics for this underserved patient population. However, development drugs remains challenge, as only 7% novel are approved clinical use. To...
Poly(vinyl)-alcohol – alginate beads with immobilized cells and a slow-release compound were optimized for long-term bioremediation of chlorinated solvents.
At the institution of implementation, terms are divided into 10-week sessions.Due to COVID-19, university decided transition all courses remote delivery two weeks before beginning Spring Quarter.This enabled restructuring taught in Quarter for start class.This rapid shift online learning presented unique challenges related specific class; however, many approaches mediating these could be applied broadly across biomedical engineering curricula.
Abstract The application of engineering tools and techniques to studying women’s health, including biomaterials-based approaches, is a research field experiencing robust growth. Biomaterials are natural or synthetic materials used repair replace damaged tissues organs replicate an organ’s physiological function. However, in addition vivo applications, there has been substantial recent interest biomaterials for vitro systems. Such artificial employed drug discovery, functional cell biological...
It is well known that during ovarian cancer progression, the omentum transforms from a thin lacy organ to thick tougher tissue. However, mechanisms regulating this transformation and implications of altered microenvironment on progression remain unclear. To address these questions, global local concentrations collagen I were determined for normal metastatic human omentum. Collagen was increased 5.3-fold in omenta patients localized areas activated fibroblasts rather than regions with high...
ABSTRACT Endometrial cancer is one of the most common gynecological cancers in world, with an estimated 382,000 new cases and 90,000 deaths each year. There no specific treatment, as underlying causes endometrial neoplasia are poorly understood. This study focuses on development validation a three-dimensional (3D) vitro multilayer, multicellularhydrogel that facilitates drug screening analysis. We hypothesized combination natural (collagen type I IV, fibrinogen, fibronectin, Laminin)...
In recent years, the matrisome, a set of proteins that make up extracellular matrix (ECM) or are closely involved in ECM behavior, has been shown to have great importance for characterizing and understanding disease pathogenesis progression. The matrisome is especially critical examining diseases characterized by extensive tissue remodeling. Endometriosis extrauterine growth endometrial tissue, making it an ideal condition study through lens gene expression. While large expression datasets...
Increasingly, the matrisome, a set of proteins that form core extracellular matrix (ECM) or are closely associated with it, has been demonstrated to play key role in tumor progression. However, context gynecological cancers, matrisome not well characterized. A holistic, yet targeted, exploration microenvironment is critical for better understanding progression identifying biomarkers cancer progression, establishing gene expression patient survival, and assisting development new targeted...
Abstract Background Alternatively-activated macrophages (AAMs), an anti-inflammatory macrophage subpopulation, have been implicated in the progression of high grade serous ovarian carcinoma (HGSOC). Increased levels AAMs are correlated with poor HGSOC survival rates, and increase attachment spread cells vitro. However, mechanism by which monocytes tumor microenvironment differentiated polarized to remains unknown. Methods Using vitro co-culture device, we cultured naïve, primary human a...
Hydrazone-crosslinked hydrogels are attractive protein delivery vehicles for regenerative medicine. However, each medicine application requires unique hydrogel properties to achieve an ideal outcome. The of a can be impacted by numerous factors involved in its fabrication. We used design experiments (DoE) statistical modeling efficiently optimize the physicochemical hyaluronic acid (HA) hydrazone-crosslinked bone regeneration. modified HA with either adipic dihydrazide (HA-ADH) or aldehyde...
Abstract Purpose The primary aim of this study was to develop an open-source Python-based software for the automated analysis dynamic cell behaviors in three-dimensional tumor models using non-confocal microscopy. This research seeks address existing gap accessible tools high-throughput cancer and endothelial dynamics vitro , facilitating rapid assessment drug sensitivity. Methods Our approach involved annotating over 1000 2 mm Z-stacks co-culture model training machine learning...
Purpose Cervical and endometrial cancers pose significant challenges in women’s healthcare due to their high mortality rates limited treatment options. High throughput screening (HTS) of cervical cancer vitro models offer a promising avenue for drug repurposing broadening patient Traditional two-dimensional (2D) cell-based screenings have capabilities capture crucial multicellular interactions, that are improved upon three dimensional (3D) tissue engineered models. However, manual...
Abstract Cervical cancer, the second leading cause of cancer-related death for women worldwide, remains a preventable yet persistent disease that disproportionately affects in low and middle-income countries (LMICs). While existing therapies treating cervical dysplasia are effective, they often inaccessible LMICs. Ethanol ablation is an alternative low-cost, accessible therapy we previously enhanced into ethyl cellulose (EC)-ethanol gel formulation to improve efficacy. When seeking evaluate...
Introduction: Cervical cancer, the second leading cause of cancer-related death for women worldwide, remains a preventable yet persistent disease that disproportionately affects in low and middle-income countries (LMICs). While existing therapies treating cervical dysplasia are effective, they often inaccessible LMICs. Ethanol ablation is an alternative low-cost, accessible therapy we previously enhanced into ethyl cellulose (EC)-ethanol gel formulation to improve efficacy. Methods: To...
The primary aim of this study was to develop an open-source Python-based software for the automated analysis dynamic cell behaviors in microphysiological models using non-confocal microscopy. This research seeks address existing gap accessible tools high-throughput endothelial tube formation and invasion vitro, facilitating rapid assessment drug sensitivity.
ABSTRACT Increasingly, the matrisome, a set of proteins that form core extracellular matrix (ECM) or are closely associated with it, has been demonstrated to play key role in tumor progression. However, context gynecological cancers, matrisome not well characterized. A holistic, yet targeted, exploration microenvironment is critical for better understanding progression identifying biomarkers cancer progression, establishing gene expression patient survival, and assisting development new...