A5065524787- Pelvic floor disorders treatments
- Hernia repair and management
- Pelvic and Acetabular Injuries
- Anorectal Disease Treatments and Outcomes
- Urological Disorders and Treatments
- Ureteral procedures and complications
- Tissue Engineering and Regenerative Medicine
- Endometriosis Research and Treatment
- Menopause: Health Impacts and Treatments
- Surgical site infection prevention
- Intestinal and Peritoneal Adhesions
- Infrastructure Maintenance and Monitoring
- Asphalt Pavement Performance Evaluation
- RNA Interference and Gene Delivery
- Cellular and Composite Structures
- Geotechnical and construction materials studies
- Body Contouring and Surgery
- Heat and Mass Transfer in Porous Media
University of Pittsburgh
2016-2025
Magee-Womens Research Institute
2015-2025
Craft Engineering Associates (United States)
2022
Objective To compare the impact of prototype prolapse mesh G ynemesh PS with that two new‐generation lower stiffness meshes, U ltra P ro and S mart M esh, on vaginal morphology structural composition. Design A mechanistic study employing a nonhuman primate model. Setting Magee‐Womens Research Institute at University ittsburgh. Population Parous rhesus macaques, similar age, weight, parity Pelvic Organ Prolapse‐Questionnaire scores. Methods Following Institutional Animal Care Use Committee...
Polypropylene meshes used in pelvic organ prolapse (POP) repair are hampered by complications. Most POP highly unstable after tensioning ex vivo, as evidenced marked deformations (pore collapse and wrinkling) that result altered structural properties material burden. By intentionally introducing collapsed pores wrinkles into a mesh normally has open remains relatively flat implantation, we reproduce complications vivo. To do this, were implanted onto the vagina of rhesus macaques nondeformed...
Abstract The application of engineering tools and techniques to studying women’s health, including biomaterials-based approaches, is a research field experiencing robust growth. Biomaterials are natural or synthetic materials used repair replace damaged tissues organs replicate an organ’s physiological function. However, in addition vivo applications, there has been substantial recent interest biomaterials for vitro systems. Such artificial employed drug discovery, functional cell biological...
Pelvic organ prolapse (POP) meshes are exposed to predominately tensile loading conditions in vivo that can lead pore collapse by 70–90%, decreasing overall porosity and providing a plausible mechanism for the contraction/shrinkage of mesh observed following implantation. To prevent collapse, we proposed design synthetic with macrostructure results auxetic behavior, pores expand laterally, instead contracting when loaded. Such behavior be achieved range structures/geometries. This study...
Objective: Some selective estrogen receptor modulators (SERMs) have been associated with increased incidence of urinary incontinence and pelvic organ prolapse. This study explored the effects five SERMs on function matrix components vagina its supportive tissues. Methods: Fifty-six rats were administered by oral gavage for 8 weeks (n = each SERM): raloxifene, tamoxifen, idoxifene, bazedoxifene at three different doses, conjugated estrogens. Thirty-two used as controls per group): sham...
Synthetic mesh for pelvic organ prolapse (POP) repair is associated with high complication rates. While current devices incorporate large pores (>1 mm), recent studies have shown that uniaxial loading of reduces pore size, raising the risk complications. However, it difficult to translate results transvaginal meshes, as in vivo multidirectional. Thus, aim this study was (1) experimentally characterize deformation diameters a response clinically relevant multidirectional and (2) develop...
Pelvic organ prolapse (POP) is the herniation of pelvic organs into vaginal space, resulting in feeling a bulge and dysfunction. Treatment POP often involves repositioning using polypropylene mesh, which has recently been found to have relatively high rates complications. Complications shown be related stiffness mismatches between vagina polypropylene, unstable knit patterns mesh deformations with mechanical loading. To overcome these limitations, we 3D-printed porous, monofilament membrane...
(Abstracted from Am J Obstet Gynecol 2017;216:153.e1–153.e9) Use of wide pore lightweight polypropylene mesh in an effort to improve anatomic outcomes the surgical repair prolapse has been associated with significant mesh-related complications. A widely used implanted (Gynemesh) shown induce a host immune foreign-body response and degenerative changes vagina when via sacrocolpopexy.
Complications following surgical repairs of pelvic organ prolapse (POP) with polypropylene mesh are common (~10%). Recent mechanistic data attributes complications in part to stiffness mismatches between the vagina and mesh. To address this problem, we developed a novel 3D printed elastomeric membrane (EM) from softer polymer, polycarbonate urethane (PCU). Given that polymers have lower strength than rigid counterparts, EMs were manufactured more material such properties similar...
Pelvic organ prolapse (POP) is a common disorder with profoundly negative impact on the physical and psychological health of women worldwide; however, exact etiology currently unknown. Parity, defined as number births, commonly identified one leading risk factors for development POP. The objective this study was to examine parity uniaxial mechanical properties sheep vagina along longitudinal direction. findings revealed that negatively impacts tangent modulus (54% decrease), tensile strength...