Objective To define the impact of prolapse mesh on biomechanical properties vagina by comparing prototype Gynemesh PS (Ethicon) to two new‐generation lower stiffness meshes, S mart M esh (Coloplast) and U ltra P ro ( E thicon). Design A study employing a nonhuman primate model. Setting University Pittsburgh, PA , USA . Population Forty‐five parous rhesus macaques. Methods Meshes were implanted via sacrocolpopexy after hysterectomy compared with sham. Because its is highly directional,...

To evaluate the impact of prolapse meshes on vaginal smooth muscle structure (VaSM) and function, to these outcomes in context mechanical textile properties mesh.Three months following implantation three polypropylene with distinct properties, mesh tissue explants were evaluated for contraction, innervation, receptor innervation density.Magee-Womens Research Institute at University Pittsburgh.Thirty-four parous rhesus macaques similar age, parity, pelvic organ quantification (POP-Q)...

The objective of this study was to elucidate the normal functional adaptations cervix in pregnancy. Utilizing a Long-Evans rodent model, divided into distal and proximal portions for virgin, mid-pregnant, four weeks postpartum animals. quasi-linear viscoelastic theory describes elastic viscous behavior cervix. A hydroxyproline assay used measure collagen content. nonlinearity response significantly increased throughout entire during pregnancy when compared virgin samples (p < 0.05)...

Synthetic mesh for pelvic organ prolapse (POP) repair is associated with high complication rates. While current devices incorporate large pores (>1 mm), recent studies have shown that uniaxial loading of reduces pore size, raising the risk complications. However, it difficult to translate results transvaginal meshes, as in vivo multidirectional. Thus, aim this study was (1) experimentally characterize deformation diameters a response clinically relevant multidirectional and (2) develop...

To assess the impact of piston-based vs peristaltic injection system technology and contrast media viscosity on achievable iodine delivery rates (IDRs) vascular enhancement in a pre-clinical study.Four injectors were tested: MEDRAD® Centargo, Stellant, CT Exprès®, motion™ using five [iopromide (300 370 mgI ml-1), iodixanol 320 ml-1, iohexol 350 iomeprol 400 ml-1]. Three experiments performed evaluating IDR corresponding circulation phantom.Experiment I: Centargo provided highest IDRs with...

(Abstracted from Am J Obstet Gynecol 2017;216:153.e1–153.e9) Use of wide pore lightweight polypropylene mesh in an effort to improve anatomic outcomes the surgical repair prolapse has been associated with significant mesh-related complications. A widely used implanted (Gynemesh) shown induce a host immune foreign-body response and degenerative changes vagina when via sacrocolpopexy.

Objective: Venous air embolism as a complication of contrast media administration from power injection systems in CT is found to occur 7%-55% patients, impacting patient safety, diagnostic image quality, workflow efficiency, and radiographer satisfaction. This study reviews the challenges associated with reactive management approaches employed on contemporary systems, proposes novel approach using proactive methods, compares impact injected volumes under simulated clinical use. Methods:...

Preterm labor is the leading cause of neonatal mortality and accounts for 70% total cost health care. Premature softening cervix has been identified as one primary causes preterm labor. As biochemistry distinct between proximal distal portions, objective this study was to determine viscoelastic properties these portions in mid-pregnancy (Day 15–16) relative virgin Long-Evans rats. This will serve establish baseline data future studies that aim induce model. The divided into were tested...

Objective: Implantation of biological or synthetic mesh is the most common method surgical intervention for pelvic organ prolapse, however, complications ensuing from these repairs occur in 15.5% cases. MatristemTM (ACell, Inc., USA) Pelvic Floor Matrix a urinary bladder matrix (UBM) device indicated transvaginal repair. This remodeled and replaced by host tissue following implantation, which raises concern that process may result loss support to vagina. Thus, goal this study was quantify...

Pelvic organ prolapse (POP) is a common disorder with profoundly negative impact on the physical and psychological health of women worldwide; however, exact etiology currently unknown. Parity, defined as number births, commonly identified one leading risk factors for development POP. The objective this study was to examine parity uniaxial mechanical properties sheep vagina along longitudinal direction. findings revealed that negatively impacts tangent modulus (54% decrease), tensile strength...

Pelvic organ prolapse (POP) is defined as the descent of pelvic organs into vaginal canal. POP a widespread condition among women, with 7% lifetime risk for single operation1. For surgical treatment, polypropylene mesh often implanted to restore support organs. However, up 20% those who undergo surgery will require repeat operations recurrent symptoms or complications2. One most common complications erosion3. Erosion characterized by degeneration native tissue in contact mesh, resulting...

Pelvic organ prolapse (POP) is a multifactorial disorder characterized by the descent of pelvic organs into vaginal canal. This associated with decreased quality life, and even depression, yet 50% women over age fifty are living POP. The cost repair POP exceeds one billion dollars annually, in United States alone. rather exorbitant figure includes surgery performed for symptom management, but does not include strategies which address underlying cause there none. Because failure rates native...

Pelvic organ prolapse is a common condition that affects roughly 30–40% of women in their lifetime (1). Although not all become symptomatic, 225,000 to 280,000 require surgery for each year Prolapse occurs when the vagina can no longer support pelvic organs. Thus, many urogynecological procedures use synthetic meshes restore supportive capacity vagina. However, significant underreported proportion undergoing mesh procedure remove surgically placed due pain, exposure, erosion, and dyspareunia...