A5013556013- Redox biology and oxidative stress
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Metastasis and carcinoma case studies
- Cancer, Hypoxia, and Metabolism
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Cell death mechanisms and regulation
- Wnt/β-catenin signaling in development and cancer
- Epigenetics and DNA Methylation
- Inflammatory Biomarkers in Disease Prognosis
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Heat shock proteins research
- Colorectal Cancer Treatments and Studies
- Hedgehog Signaling Pathway Studies
- Intraperitoneal and Appendiceal Malignancies
- Ferroptosis and cancer prognosis
- Intestinal Malrotation and Obstruction Disorders
- Metal-Catalyzed Oxygenation Mechanisms
- Cancer, Lipids, and Metabolism
- Glutathione Transferases and Polymorphisms
- Nitric Oxide and Endothelin Effects
- Molecular Biology Techniques and Applications
Chongqing Cancer Hospital
2019-2024
Chongqing University
2019-2024
Chongqing Medical University
2014-2017
The Affiliated Yongchuan Hospital of Chongqing Medical University
2014-2017
Although the outcome of patients with colorectal cancer (CRC) has improved significantly, prognosis evaluation still presents challenges due to disease heterogeneity. Increasing evidences revealed close correlation between aberrant expression certain RNAs and prognosis. We envisioned that combined multiple types into a single classifier could improve postoperative risk classification add prognostic value current stage system. Firstly, differentially expressed including mRNAs, miRNAs lncRNAs...
Sestrin 2 is a conserved antioxidant protein that reduces reactive oxygen species (ROS) and inhibits mammalian target of rapamycin complex 1 (mTORC1). We previously showed sestrin abnormally decreased in colorectal cancer (CRC). To elucidate the molecular mechanism behind potential contribution to CRC, we used lentiviral expression vector system determine effects overexpression on human CRC cells. found ROS production, inhibited cell growth, stimulated apoptosis two lines. In parallel,...
Although, 5-Fluorouracil (5-FU) remains widely used in adjuvant therapy patients with colon cancer, resistance to 5-FU-based chemotherapy is an important reason for treatment failure. Recent studies have reported that enhanced reactive oxygen species (ROS) scavenging system shows drug 5-FU. Peroxiredoxin-2 (PRDX2), member of the ROS system, and may be a potential target promotes chemosensitivity 5-FU cancer. Here, we depleted PRDX2 by PRDX2-shRNA-LV transduction two cancer cell lines found...
Cancer stem cells (CSCs) are a key target for reducing tumor growth, metastasis, and recurrence. Redox status is critical factor in the maintenance of CSCs, antioxidant enzyme Peroxiredoxin 2 (Prdx2) plays an important role development colon cancer. Therefore, we investigated contribution Prdx2 to stemness CSCs. Here, used short-hairpin RNAs Prdx2-overexpression vector determine effects Prdx2. We demonstrated that knockdown reduced self-renewal sphere formation resulted increased...
Although human peroxiredoxin 2 (PRDX2) has been implicated in tumor progression (e.g., invasion and metastasis), little is known regarding its role the epithelial‑mesenchymal transition (EMT) process during tumorigenesis. The present study offers first evidence, to best of our knowledge, that antioxidant enzyme PRDX2 an important regulating EMT process. It was demonstrated overexpression leads changes cell morphology vitro potent inhibition transforming growth factor (TGF)‑β1‑induced...
Hypoxia is a common feature of solid tumor, and direct stress that triggers apoptosis in many human cell types. As one cancer, hypoxia exists the whole course colon cancer occurrence progression. Our previous studies shown induce high expression phospholipase D2 (PLD2) survivin cells. However, correlation between PLD2 hypoxic cells remains unknown. In this study, we observed significantly elevated levels tissues This positive them, co-expression has with clinicpatholic features including...
Almost all elderly patients with peritoneal metastatic gastric cancer (PGC) are unlikely to tolerate cytoreductive surgery combined hyperthermic intraperitoneal chemotherapy (HIPEC) and adjuvant chemotherapy. However, determining how optimize the treatment strategy for such has always been a clinical problem. Both HIPEC palliative can benefit PGC. Therefore, optimizing regimens potential value in reducing side effects, improving tolerance effectiveness.To explore effect of containing...
The application of immunotherapy for treating colorectal cancer (CRC) is currently a research hotspot, and neoadjuvant has shown initial success in CRC. watch-and-wait (W&W) approach often used after achieving clinical complete response (cCR) following preoperative treatment low rectal cancer. However, thus far, the W&W not been reported patients with colon Here, we report case 64-year-old patient heterogeneous multigenic CRC who achieved cCR five sessions before surgery. A...
Situs inversus totalis (SIT) is a rare group of congenital developmental malformations in the clinical setting, with all organs chest and abdomen existing mirror image reversal their normal positions. Few reports have described laparoscopic surgery for colorectal cancer patients SIT, it considered difficult even an experienced surgeon because positioning. We present case report radical resection colonic splenic flexure carcinoma patient SIT.A 72-year-old male was referred to our hospital...
Objective: To investigate the short-term efficacy of laparoscopic radical resection right-sided colon cancer with two different surgeon positions and trocar placements. Methods: The data 78 patients who underwent between January 2018 August 2019 were retrospectively analysed. surgical method was selected by patients. divided into groups according to surgeons’ positioning habits group lead standing patient’s legs had 35 patients, at left side patient 43 operation time, intraoperative blood...
Background: In traditional laparoscopic colorectal cancer surgery, the surgeon’s method assess intestinal stumps blood supply is subject to certain subjectivity and blindness. Indocyanine green (ICG) real-time perfusion fluorescence angiography in radical resection of rectal has great potential clinical value can visually judge tract improve surgery safety, reduce postoperative complications, ensure recovery patients after surgery. Objective: To explore efficacy intraoperative use...