A5091554344- Process Optimization and Integration
- Advanced Control Systems Optimization
- Chemistry and Chemical Engineering
- Viral Infectious Diseases and Gene Expression in Insects
- biodegradable polymer synthesis and properties
- Microbial Metabolic Engineering and Bioproduction
- Sustainable Supply Chain Management
- Protein purification and stability
- Biodiesel Production and Applications
- Extraction and Separation Processes
- Crystallization and Solubility Studies
- Monoclonal and Polyclonal Antibodies Research
- Catalysis and Oxidation Reactions
- Microfluidic and Capillary Electrophoresis Applications
- Capital Investment and Risk Analysis
- Ionic liquids properties and applications
- Membrane Separation and Gas Transport
- Product Development and Customization
- Flow Measurement and Analysis
- Optimization and Mathematical Programming
- Operations Management Techniques
- Thermal and Kinetic Analysis
- Carbon dioxide utilization in catalysis
- Carbon Dioxide Capture Technologies
- Catalysis for Biomass Conversion
Novo Nordisk (Denmark)
2017-2024
Cell Biotech (South Korea)
2020
Technical University of Denmark
2010-2017
Process intensification (PI) has the potential to improve existing as well conceptual processes, in order achieve a more sustainable production. PI can be achieved at different levels, that is unit operations, functional, and/or phenomena level. The highest impact expected by looking processes lowest level of aggregation which In this paper, based synthesis/design methodology incorporating process presented. Using methodology, systematic identification necessary and desirable (integrated)...
Production planning is widely studied, and mathematical formulations have been proposed for various problems. The capacity level usually fixed which requires a separate solution of the problem. In this paper, methodology setting up solving integrated production problems given manufacturing network. Mixed-integer linear programming are assembled from constraint objectives database based on system characterization their determines whether levels should be changed. An indirect approach to...
Abstract The fifth modeling workshop (5MW) was held in June 2023 at Favrholm, Denmark and sponsored by Recovery of Biological Products Conference Series. goal the to assemble practitioners review discuss current state, progress since last fourth mini (4MMW), gaps opportunities for development, deployment maintenance models bioprocess applications. Areas focus were four categories: biophysics molecular modeling, mechanistic computational fluid dynamics (CFD) plant modeling. Highlights...
Biodiesel is a promising fuel alternative compared to traditional diesel obtained from conventional sources such as fossil fuel. Many flowsheet alternatives exist for the production of biodiesel and therefore it necessary evaluate these using defined criteria also process intensification opportunities. This work focuses on three main aspects that have been incorporated into systematic computer-aided framework sustainable design. First, creation generic superstructure, which consists all...
The design of biopharmaceutical processes is predominantly driven by the domain experimental process design. This approach can be further improved combining multiple information such as experiments, unit models, and flowsheet models. Approaches consisting methods models provide framework for exploring, analyzing, ultimately evaluating combinatorial space all possible designs within molecule-to-manufacturing value chain. In recent years, modular are interest in pharmaceutical industry because...
In silico frameworks have the potential to improve experimentally designed processes for monoclonal antibody (mAb) manufacturing. this paper, a framework analysis of mAb process alternatives is presented with objective realizing improvements from flowsheet perspective. The key elements proposed method include generation and decomposition design space, formulation model, simulation evaluation alternative designs. An example an new technology step in manufacturing given demonstrate application...
This work presents a methodology for capacity planning under uncertainty in general multi-stage manufacturing networks. Multiple lines are available and the production time on each line must be divided between set of materials. The generates mixed-integer linear programming models that represent expansions with economy scale costs functions details. A deterministic model is solved to create baseline impact investigated by sensitivity analysis stochastic programming. applicability exemplified...
Municipal solid waste (MSW) landfills are one of the largest human-generated sources methane emissions in United States and other countries globally. Methane is believed to be a very potent greenhouse gas that key contributor global climate change, over 21 times stronger than CO2. also has short (10-year) atmospheric life. Because both short-lived, reducing from MSW best ways achieve near-term beneficial impact mitigating change. The Environmental Protection Agency estimates landfill (LFG)...