A5045736076- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- Metabolism and Genetic Disorders
- HIV/AIDS drug development and treatment
- Synthesis and Characterization of Heterocyclic Compounds
- Computational Drug Discovery Methods
- Protein Kinase Regulation and GTPase Signaling
- Autophagy in Disease and Therapy
- Genetics and Neurodevelopmental Disorders
- RNA and protein synthesis mechanisms
- Adipose Tissue and Metabolism
- HIV Research and Treatment
University of Veterinary Medicine Vienna
2021-2022
Article2 November 2022Open Access Source DataTransparent process TMBIM5 is the Ca2+/H+ antiporter of mammalian mitochondria Shane Austin orcid.org/0000-0002-8698-6055 Department Internal Medicine I and Comprehensive Cancer Center, Medical University Vienna, Austria Contribution: Conceptualization, Data curation, Formal analysis, Validation, Investigation, Visualization, Methodology, Writing - original draft, review & editing Search for more papers by this author Ronald Mekis Biomedical...
Abstract Mitochondrial Ca 2+ ions are crucial regulators of bioenergetics, cell death pathways and cytosolic homeostasis. content strictly depends on transporters. In recent decades, the major players responsible for mitochondrial uptake release have been identified, except /H + exchanger (CHE). Originally identified as K exchanger, LETM1 was also considered a candidate CHE. Defining interactome LETM1, we MICS1, only member TMBIM family. Applying cell-based cell-free biochemical assays, here...