A5101573862- Colorectal Cancer Surgical Treatments
- Cardiac electrophysiology and arrhythmias
- Gastric Cancer Management and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Colorectal Cancer Treatments and Studies
- Enhanced Recovery After Surgery
- Colorectal and Anal Carcinomas
- Diverticular Disease and Complications
- Genetic factors in colorectal cancer
- Inflammatory Biomarkers in Disease Prognosis
- Integrated Circuits and Semiconductor Failure Analysis
- Advances in Oncology and Radiotherapy
- Anorectal Disease Treatments and Outcomes
- Cardiomyopathy and Myosin Studies
- Esophageal and GI Pathology
- COVID-19 and healthcare impacts
- Cancer Genomics and Diagnostics
- Surgical site infection prevention
- Metastasis and carcinoma case studies
- Appendicitis Diagnosis and Management
State Scientific Center of Coloproctology
2017-2025
The Ohio State University
2021-2024
AIM: to identify risk factors for perforation during colorectal ESD early colon cancer.PATIENTS AND METHODS: the study included 61 patients with cancer who underwent in 2018–2023. Perforation was defined as a deep muscular layer defect down serosa its preservation without connection free peritoneal cavity. Clinical ESD, including age, gender, tumor morphology, size, location, procedure time, were analyzed.RESULTS: mean specimen size 20.0 (1.50–2.80) mm. The overall en bloc resection rate...
Background: This study aims to examine the factors involved in anastomotic leak (AL) following low anterior resection and total mesorectal excision (LAR-TME) determine usefulness of early measurement inflammatory biomarkers C-Reactive Protein (CRP) Procalcitonin (PCT). Methods: One hundred patients undergoing LAR-TME with a proximal diverting stoma were analyzed between 2013 2016. Postoperative CRP PCT levels measured on 3rd 6th postoperative days. Results: There 11 clinical leaks negative...
Aim of investigation. To determine diagnostic value procalcitonin (PCT) and C-reactive protein (CRP) at anastomotic leakage (AL) following lower anterior resection (LAR) the rectum. Material methods. Overall 100 patients underwent surgery for epithelial tumors rectum in period 2013-2016 yy volume LAR with formation anastomosis preventive stoma. In without clinical symptoms radiopaque study was performed order to identify asymptomatic AL on day 7 after surgery. rate, difference PCT CRP levels...
Anastomotic leakage (AL) following surgical interventions associated with total mesorectal excision (TME) and formation of fistula is the most common dangerous complication this kind intervention, its incidence 17 %. OBJECTIVE. Determine diagnostic value Neutrophil-to-Lymphocyte Rato (NLR) in diagnosis low colorectal anastomosis after anterior resection (LAR). Patients methods: 100 patients epithelial tumors rectum period 2013-2016 yy underwent surgery - LAR preventive stoma. In without...
Background: Mutations in the SCN5A gene, encoding cardiac voltage-gates sodium channels (Na v 1.5) are associated with life threatening arrhythmias. Recently a missense mutation selectivity filter, SCN5A-K1419E, has been identified patients Brugada syndrome and also linked to long QT. Prior studies demonstrated that SCN5A-K1419E substitution alters ion of Na V 1.5, conferring Ca 2+ permeability, thereby lowering overall conductance. However, arrhythmogenic mechanism filter mutations have not...
In the review data concerning modern methods of endoscopic treatment colonic strictures are presented. Relevance this problem, reasons for development, clinical picture and procedures presented in detail. The analysis Russian foreign literature with an assessment effectiveness feasibility various has been done. Despite variety ways existing stricture’s treatment, there still no evidence-based on efficiency safety approaches. Thus, a number unresolved topical issues that require further research.
To determine diagnostic value of neutrophil CD64 index (iCD64n) in the diagnosis postoperative infectious complications after colorectal resections.Seventy-three patients underwent surgery for period from January to December 2018. These were included into a single-center study. Peripheral blood samples taken on 3 and 6 days (POD) check iCD64n level. We analyzed incidence complications, sensitivity (Se) specificity (Sp) level 3rd 6th POD.Postoperative developed 10 (13.7%) patients. Median was...
To determine mutations in the plasma KRAS gene patients with colorectal cancer was aim of this study. The material obtained from 44 different stages (T1-4N0-2bM0-1c). Plasma for presence mutation circulating tumor DNA investigated using digital droplet polymerase chain reaction (PCR). isolated 1 ml were detected 13 (30%) stages. Of these, stage II, there 3 patients, III - 5 and IV 5. Patients who did not have analyzed plasma. Five more found II highest concentrations IV. increase volume to...
AIM: to compare methods of high and low ligation the inferior mesenteric artery (IMA) in relation early late outcomes surgery for rectal sigmoid cancer. MATERIALS AND METHODS: systematic review performed accordance with PRISMA practice guidelines. RESULTS: eighteen studies (5 randomized clinical trials 13 retrospective studies) are included study. The meta-analysis demonstrated that left colic (LCA) preservation significantly reduced incidence anasto- motic leaks compared IMA (OR = 1.60; CI...
The COVID-19 pandemic, with it is rapid increase in new cases and deaths, has caused hospital overload around the world, creating an unprecedented challenge for health systems requiring development of reliable evidence-based guidelines. Moreover, this led to urgent identification non-COVID priorities. cancer service must be restructured. Diagnosis treatment colorectal background pandemic requires a restrained approach based on priority patient care.
Objective. Саrbohydrаte antigen 19-9 (CA 19-9) is the frequently used tumor marker in clinical setting of colorectal cancer (CRC). This study was designed to investigate correlation between preoperative serum levels CA (pre-CA and clinicopathologic factors patients with CRC. Patients methods. A performed on 482 histologically diagnosed adenocarcinoma January 2016 December 2017, based retrospective collected data. The data such as age, sex, size tumor, differentiation (G), depth (T), lymph...
Calmodulin (CaM) mutants are associated with severe arrhythmias (calmodulinopathy). While dysregulation of Ca 2+ handling proteins (RyR2, V 1.2) known mediators calmodulinopathy, the role Na + channels (Na s) remains unclear. Interestingly, effects on 1.2 do not fully explain action potential (AP) prolongation by long QT syndrome CaM mutant D96V. We investigated D96V-CaM and its arrhythmogenic impact. In wild-type (WT) murine cardiomyocytes (CM) dialysis (6.5 μM) via a patch pipette...