A5074233266- Birth, Development, and Health
- Immune Response and Inflammation
- Diabetes and associated disorders
- Per- and polyfluoroalkyl substances research
- Epigenetics and DNA Methylation
- T-cell and B-cell Immunology
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- Chromosomal and Genetic Variations
- Genomic variations and chromosomal abnormalities
- CRISPR and Genetic Engineering
- Thermal Radiation and Cooling Technologies
- Energy and Environment Impacts
- Immune Cell Function and Interaction
- Genomics and Rare Diseases
- Air Quality and Health Impacts
- COVID-19 impact on air quality
- Toxic Organic Pollutants Impact
- Advanced biosensing and bioanalysis techniques
- Atherosclerosis and Cardiovascular Diseases
- Quantum Electrodynamics and Casimir Effect
University of Rochester
2015-2024
Kiel University
2024
University of Lübeck
2024
Brandeis University
2014
Although Piwi proteins and Piwi-interacting RNAs (piRNAs) genetically repress transposable elements (TEs), it is unclear how the highly diverse piRNA populations direct to silence TE targets without silencing entire transcriptome. To determine capacity of piRNA-mediated silencing, we introduced reporter genes into Drosophila OSS cells, which express microRNAs (miRNAs) piRNAs, compared pathway Argonaute in gene regulation. Reporter constructs containing several target sites that were robustly...
Abstract Successfully fighting infection requires a properly tuned immune system. Recent epidemiological studies link exposure to pollutants that bind the aryl hydrocarbon receptor (AHR) during development with poorer responses later in life. Yet, how developmental triggering of AHR durably alters cell function remains unknown. Using mouse model, we show activation leads long-lasting reduction response CD8+ T cells influenza virus infection, critical for resolving primary infection....
Per- and polyfluoroalkyl substances (PFAS) are anthropogenic organofluorine compounds that persist indefinitely in the environment bioaccumulate throughout all trophic levels. Biomonitoring efforts have detected multiple PFAS serum of most people. Immune suppression has been among consistent effects exposure to PFAS. often co-occur as mixtures environment, however, few studies examined immunosuppression or determined whether affects immune function context infection. In this study,...
Recent studies have linked health fates of children to environmental exposures their great grandparents. However, few considered whether ancestral influence immune function across generations. Here, we report transgenerational inheritance altered T cell responses resulting from maternal (F0) exposure the aryl hydrocarbon receptor ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Since F0 TCDD has been transmission reproductive problems, asked also caused changes in function. effects on CD8
Abstract Developmental exposures can influence life-long health; yet, counteracting negative consequences is challenging due to poor understanding of cellular mechanisms. The aryl hydrocarbon receptor (AHR) binds many small molecules, including numerous pollutants. exposure the signature environmental AHR ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) significantly dampens adaptive immune responses influenza A virus in adult offspring. CD8+ cytotoxic T lymphocytes (CTL) are crucial for...
Background: Early life environmental exposures can have lasting effects on the function of immune system and contribute to disease later in life. Epidemiological studies linked early exposure xenobiotics that bind aryl hydrocarbon receptor (AhR) with dysregulated responses Among cells influenced by developmental activation AhR are CD4+ T cells. Yet, underlying affected cellular pathways via which activating causes remain into adulthood unclear. Objective: Our goal was identify mechanisms...
Abstract Early life environmental exposures drive lasting changes to the function of immune system and can contribute disease later in life. One ways factors act is through cellular receptors. The aryl hydrocarbon receptor (AHR) expressed by cells binds numerous xenobiotics. exposure chemicals that bind AHR impairs CD4 + T cell responses influenza A virus (IAV) infection adulthood. However, mechanisms underlie these durable remain poorly defined. Transcriptomic profiling sorted identified...
Abstract Purpose Short-read genome sequencing (GS) is a comprehensive genetic testing method capable of detecting multiple variant types. Despite its technical advantages, systemic comparisons singleton GS (sGS), trio (tGS), and exome sequencing-based standard-of-care (SoC) in real-world diagnostics remain limited. Methods We systematically compared sGS, tGS, SoC 448 patients with rare diseases blinded, prospective study. Three independent teams evaluated the diagnostic yield, detection...