A5024944246- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Multiple Sclerosis Research Studies
- Nerve injury and regeneration
- Mitochondrial Function and Pathology
- MicroRNA in disease regulation
- RNA regulation and disease
- Axon Guidance and Neuronal Signaling
- Polyomavirus and related diseases
- Neurological Disease Mechanisms and Treatments
- Tissue Engineering and Regenerative Medicine
- Biochemical Analysis and Sensing Techniques
- RNA Interference and Gene Delivery
- Anesthesia and Neurotoxicity Research
- Adenosine and Purinergic Signaling
- Anesthesia and Pain Management
- Pituitary Gland Disorders and Treatments
- Memory and Neural Mechanisms
- Cannabis and Cannabinoid Research
- Neural dynamics and brain function
- S100 Proteins and Annexins
- Immune Response and Inflammation
- Cell death mechanisms and regulation
- Spine and Intervertebral Disc Pathology
Achucarro Basque Center for Neuroscience
2013-2025
University of the Basque Country
2008-2025
Biomedical Research Networking Center on Neurodegenerative Diseases
2015-2025
BioCruces Health research Institute
2025
Instituto de Salud Carlos III
2025
Centre National de la Recherche Scientifique
2024
Basque Center for Materials, Applications and Nanostructures
2024
Université de Bordeaux
2024
Ikerbasque
2024
Donostia International Physics Center
2024
Oligodendrocyte death and demyelination are hallmarks of multiple sclerosis (MS). Here we show that ATP signaling can trigger oligodendrocyte excitotoxicity via activation calcium-permeable P2X 7 purinergic receptors expressed by these cells. Sustained in vivo causes lesions reminiscent the major features MS plaques, i.e., demyelination, death, axonal damage. In addition, treatment with antagonists chronic experimental autoimmune encephalomyelitis (EAE), a model MS, reduces ameliorates...
Glutamate excitotoxicity and complement attack have both been implicated separately in the generation of tissue damage multiple sclerosis its animal model, experimental autoimmune encephalomyelitis. Here, we investigated whether glutamate receptor activation sensitizes oligodendrocytes to attack. We found that a brief incubation with followed by exposure was lethal vitro freshly isolated optic nerves. Complement toxicity induced kainate but not AMPA receptors abolished removing calcium from...
Progressive multiple sclerosis (MS) is characterized clinically by the accumulation of neurological disability without unequivocal recovery. Understanding mechanisms that determine entering in this stage disease a great challenge order to identify potential therapeutic targets. Recent advances defining more accurately progressive phenotype MS, have concluded differences between primary and secondary forms are relatively quantitative rather than qualitative. In both cases, large number...
Activation of the subventricular zone (SVZ) following cerebral ischemia is one brain’s early responses to counteract neuron loss and minimize tissue damage. Impaired brain regions communicate with SVZ through various chemotactic signals that promote cell migration differentiation, primarily involving neural stem cells (NSC), neuroblasts, or glioblasts. However, activation gliogenesis role newly formed astrocytes in post-ischemic scenario remain subjects debate. We have previously...
Multiple sclerosis (MS) is an autoimmune disease causing central nervous system (CNS) demyelination and axonal injury. In the last years importance of astrocytes in MS rapidly increasing, recognizing as highly active players pathogenesis. Usually role assigned to lesions has been formation glial scar, but now their implication during lesion immune response increasingly recognized. Since are a heterogeneous cell population with diverse roles CNS, aim this study was analyze putative clonal...
Abstract Recent findings suggest that synaptic‐type glutamate signaling operates between axons and their supporting glial cells. Glutamate reuptake will be a necessary component of such system. Evidence for glutamate‐mediated damage oligodendroglia somata processes in white matter suggests regulation structures is also clinical importance. The expression transporters was examined postnatal Day 14–17 (P14–17) mouse mature rat optic nerve using immuno‐histochemistry immuno‐electron microscopy....
Activation of the subventricular zone (SVZ) following cerebral ischemia is one brain’s early responses to counteract neuron loss and minimize tissue damage. Impaired brain regions communicate with SVZ through various chemotactic signals that promote cell migration differentiation, primarily involving neural stem cells (NSC), neuroblasts, or glioblasts. However, activation gliogenesis role newly formed astrocytes in post-ischemic scenario remain subjects debate. We have previously...
Oligodendrocytes are highly vulnerable to glutamate excitotoxicity, a central mechanism involved in tissue damage Multiple Sclerosis (MS). Sustained activation of AMPA receptors rat oligodendrocytes induces cytosolic calcium overload, mitochondrial depolarization, increase reactive oxygen species, and intracelular pathways resulting apoptotic cell death. Although many signals driven by excitotoxicity have been identified, some the key players still under investigation. Casein kinase 2 (CK2)...
NG2-glia, also known as oligodendrocyte precursor cells (OPCs), have the potential to generate new mature oligodendrocytes and thus, contribute tissue repair in demyelinating diseases like multiple sclerosis (MS). Once activated response brain damage, NG2-glial proliferate, they acquire a reactive phenotype heterogeneous appearance. Here, we set out investigate distribution phenotypic diversity of NG2-glia relative their ontogenic origin, whether there is clonal lesion an experimental...
Abstract We have studied the presence and distribution of α-amino-3–hydroxy-5–methyl-4–isoxazolepropionate (AMPA)-selective glutamate receptor subunits (GluR 1, 2, 3, 4) in adult cat visual cortical areas 17, 18, 19, lateral suprasylvian (LSA). Reverse transcription-polymerase chain reaction (RT-PCR) amplification indicated that genes encoding GluR 4 are expressed these Western blot analysis revealed size corresponding peptides is similar to those described rat brain. In situ hybridization...
Abstract A mouse monoclonal antibody (5B9), directed against a carbohydrate epitope of human epidermal growth factor receptor (EGFR), recognized an 81‐kDalton glycoprotein in buffer‐soluble and detergent‐solubilized rat brain extracts (BE). The was more abundant prepared from injured than those normal tissue. Removal BE the antigens by 5B9 increased their astrocyte mitogenic activity. Sections cultures derived damaged brain, enriched microglia, showed immunoreactivity ED1‐positive cells....
Activation of the subventricular zone (SVZ) after cerebral ischemia is one early responses in brain to counteract loss neurons and reduce tissue damage. Impaired regions communicate with SVZ through many chemotactic messages that result neural stem cells (NSC) migration differentiation. However, activation gliogenesis role newborn astrocytes post-ischemic scenario still under debate. We have previously shown adenosine release prompts generate new astrocytes. Here, we use transient mice...
Activation of the subventricular zone (SVZ) following cerebral ischemia is one brain’s early responses to counteract neuron loss and minimize tissue damage. Impaired brain regions communicate with SVZ through various chemotactic signals that promote cell migration differentiation, primarily involving neural stem cells (NSC), neuroblasts, or glioblasts. However, activation gliogenesis role newly formed astrocytes in post-ischemic scenario remain subjects debate. We have previously...