A5028023224- Synthesis and biological activity
- Protein Tyrosine Phosphatases
- Bioactive Compounds and Antitumor Agents
- Computational Drug Discovery Methods
- Galectins and Cancer Biology
- Diabetes Treatment and Management
- Synthesis of β-Lactam Compounds
- Metabolism, Diabetes, and Cancer
- SARS-CoV-2 and COVID-19 Research
- Synthesis and Reactions of Organic Compounds
- vaccines and immunoinformatics approaches
- Advanced Drug Delivery Systems
- Chemical synthesis and pharmacological studies
- thermodynamics and calorimetric analyses
- Synthesis of heterocyclic compounds
- Chemical Reactions and Isotopes
- Diabetes Management and Research
- RNA Interference and Gene Delivery
- Quinazolinone synthesis and applications
- Multicomponent Synthesis of Heterocycles
- Steroid Chemistry and Biochemistry
- Synthesis and Characterization of Heterocyclic Compounds
- Pancreatic function and diabetes
- Machine Learning in Materials Science
- Carbohydrate Chemistry and Synthesis
National Institute of Technology Rourkela
2020-2021
Panjab University
2013-2021
Birla Institute of Technology, Mesra
2010-2013
COVID-19 pandemic has created a healthcare crisis across the world and put human life under life-threatening circumstances. The recent discovery of crystallized structure main protease (Mpro) from SARS-CoV-2 provided an opportunity for utilizing computational tools as effective method drug discovery. Targeting viral replication remained strategy development. Mpro SARS-COV-2 is key protein in it involved processing polyproteins to various structural nonstructural proteins. Thus, represents...
Protein tyrosine phosphatase 1B (PTP1B) has been identified as a negative regulator of insulin and leptin signalling pathway; hence, it can be considered new therapeutic target intervention for the treatment type 2 diabetes. Inhibition this molecular takes care both diabetes obesity, i.e. diabestiy. In order to get more information on identification optimization lead, pharmacophore modelling, atom-based 3D QSAR, docking dynamics studies were carried out set ligands containing thiazolidine...
Abstract: Background: Diabetes mellitus, a lifestyle related global health crisis has rapidly engulfed the entire world. In past, various thiazolidinedione derivatives have been successfully developed for management of diabetes. Materials and Methods: Herein, we report synthesis, characterization (1H-NMR, 13C-NMR mass spectroscopy methods) novel aryl sulfonyloxy-5-arylidene thiazolidine-2,4-dione analogues. Anti-hyperglycaemic action (Alloxan-induced method) was performed evaluating...
Metabolic disorders associated with diabetic patients are a serious concern. Aldose reductase (ALR2) has been identified as first rate-limiting enzyme in the polyol pathway which catalyzes reduction of glucose to sorbitol. It represents one validated targets develop potential new chemical entities for prevention and subsequent progression microvascular complications. In order further understand intricate structural prerequisites molecules act ALR2 inhibitors, ligand-based pharmacophore...
Benign prostatic hyperplasia is non-malignant enlargement of prostate gland which results in severe lower urinary tract symptoms and affects the quality life patients. 5-Reductase inhibitors play a crucial role management benign diseases with low toxicity have been major thrust area for its application cancers limited success. In continuation our program to develop novel 5-reductase inhibitors, we report herein synthesis biological evaluation...