A5078077421- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- HIV/AIDS drug development and treatment
- Synthesis of heterocyclic compounds
- Crystallography and molecular interactions
- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Hepatitis C virus research
- Synthesis and Characterization of Heterocyclic Compounds
- Biochemical and Molecular Research
- Click Chemistry and Applications
- HIV Research and Treatment
- Synthesis of Organic Compounds
- Chemical Synthesis and Analysis
- Quinazolinone synthesis and applications
- Synthetic Organic Chemistry Methods
- Multicomponent Synthesis of Heterocycles
- Herpesvirus Infections and Treatments
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Cancer therapeutics and mechanisms
- Synthesis and Catalytic Reactions
- Synthesis and Reactions of Organic Compounds
- Hepatitis B Virus Studies
- Computational Drug Discovery Methods
- Crystal structures of chemical compounds
Birla Institute of Technology, Mesra
2015-2025
Ranchi University
2014-2019
University of Georgia
2006-2011
Georgia College & State University
2006-2010
Southern Research Institute
2008
Georgetown University
2008
Georgetown University Medical Center
2008
Emory University
2008
Central Drug Research Institute
2001-2005
The multifactorial nature of cancer requires treatment that involves simultaneous targeting associated overexpressed proteins and cell signaling pathways, possibly leading to synergistic effects. Herein, we present a systematic study the inhibition human topoisomerases (hTopos) histone deacetylases (HDACs) by multitargeted quinoline-bridged hydroxamic acid derivatives. These compounds were rationally designed considering pharmacophoric features catalytic sites cross-talk proteins,...
The discovery of selective and potent inhibitors through de novo pathways is essential to combat drug resistance in chronic hepatitis B (CHB) infections. Recent studies have highlighted that neplanocin A (NepA) derivatives are biologically the virus (HBV). In this study, we designed, synthesized, evaluated various pyrazolo[3,4-d]pyrimidine-based NepA analogues (4a-h) for their anti-HBV activity. Notably, analogue 4g demonstrated significant activity against HBV replication, with EC50 (HBV...
Telmisartan (TLM), a nonpeptide angiotensin II antagonist, is widely prescribed for treating arterial hypertension and marketed by the innovator with trade name of Micardis plus. exhibits low aqueous solubility in pH range 3-7, which physiological pH. For addressing issue poor TLM, its commercial form makes use inorganic alkalinizers. The present work illustrates attempt to improve telmisartan via crystal engineering approach. A novel solid phthalic acid was obtained through solution...
Synthesis, antibacterial and potential anti-HIV activity of some novel imidazole analogs A series 1-(2-methyl-4-nitro-imidazol-1-yl)-3-arylaminopropan-2-ones ( 2a-e ), 2-methyl-5-nitro-1-{2-[arylmethoxy] ethyl}-1 H -imidazoles 5a-d N -(3-hydroxyphenyl)-2-(substituted imidazol-1-yl)alkanamides 8a-e ) were synthesized with the aim to develop broad-spectrum chemotherapeutic properties. Title compounds evaluated for their activities.
New, highly stable tricyclic antitubercular ozonides 9 and 10 derived from artemisinin are reported in 39 9% yields, respectively. The ozonide groups of were found to be under strong basic acidic conditions. absolute configuration was confirmed by X-ray crystallography. Ozonide shows promising activity against M. tuberculosis H37Ra H37Rv with MIC values 0.39 3.12 μg/mL,
A rapid and efficient synthesis of aminotetrazole from aryl azides, isocyanides, TMSN3 is developed. The reaction promoted by sequential Pd(0)/Fe(III) catalysis. sequence utilizes the Pd-catalyzed azide–isocyanide denitrogenative coupling to generate unsymmetric carbodiimide in situ, which reacts with presence FeCl3 a single pot. methodology has distinct advantages over traditional synthetic approaches where toxic Hg Pb salts are employed at stoichiometric scale.
Herpes genitalis, caused by HSV-2, is an incurable genital ulcerative disease transmitted sexual intercourse. The virus establishes life-long latency in sacral root ganglia and reported to have synergistic relationship with HIV-1 transmission. Till date no effective vaccine available, while the existing therapy frequently yielded drug resistance, toxicity treatment failure. Thus, there a pressing need for non-nucleotide antiviral agent from traditional source. Based on ethnomedicinal use we...
Several 7-deaza-6-benzylthioinosine analogues with varied substituents on aromatic ring were synthesized and evaluated against Toxoplasma gondii adenosine kinase (EC.2.7.1.20). Structure−activity relationships indicated that the nitrogen atom at 7-position does not appear to be a critical structural requirement. Molecular modeling reveals 7-deazapurine motif provided flexibility 6-benzylthio group as result of absence H-bonding between N7 Thr140. This allowed better fitting into hydrophobic...
This paper is an attempt to evaluate the anti-inflammatory and analgesic activities possible mechanism of action tender leaf extracts Shorea robusta , traditionally used in ailments related inflammation. The acetic-acid-induced writhing tail flick tests were carried out for activity, while activity was evaluated carrageenan-and dextran- induced paw edema cotton-pellet-induced granuloma model. vascular permeability, erythrocyte membrane stabilization, release proinflammatory mediators (nitric...
Biophysical studies have shown that each molecule of calsequestrin 1 (CASQ1) can bind about 70–80 Ca2+ ions. However, the nature Ca2+-binding sites has not yet been fully characterized. In this study, we employed in silico approaches to identify binding and understand molecular basis CASQ1–Ca2+ recognition. We built protein model by extracting atomic coordinates for back-to-back dimeric unit from recently solved hexameric CASQ1 structure (PDB id: 3UOM) adding missing C-terminal residues...
The rapid synthesis of the isoindolinone skeleton has been accomplished by a palladium‐catalyzed one‐pot tandem process, which consists an isocyanide insertion/hydration (carboxamidation) and 5‐ exo ‐ dig cycloisomerization (hydroamidation) reaction sequence that afforded products in good to excellent yields. Preliminary mechanistic studies this sequential C–C/C–O/C–N bond formation process suggests carboxamidation step is palladium‐dependent, whereas hydroamidation solely mediated base...
A one pot water mediated synthesis of sesamol analogous using Betti Base synthetic approach. The reaction was optimized with various solvents and catalysts, but the product formed a high yield in aqueous ethanol condition. examined strategy offers many advantages such as green solvent, purification without column chromatography, catalyst-free synthesis. synthesized molecules were investigated for molecular docking DFT studies. In silico parameter showed that compound 4h has lowest affinity...
Calsequestrin undergoes dynamic polymerization with increasing calcium concentration by front-to-front dimerization and back-to-back packing, forming wire-shaped structures. A recent finding that point mutation R33Q leads to lethal catecholaminergic polymorphic ventricular tachycardia (CPVT) implies a crucial role for the N terminus. In this study, we demonstrate resides in highly conserved alternately charged residue cluster (DGKDR; 1) N-terminal end of calsequestrin. We further show...