A5037917828- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Multicomponent Synthesis of Heterocycles
- Synthesis and Reactivity of Heterocycles
- X-ray Diffraction in Crystallography
- Synthesis and Biological Evaluation
- Crystallization and Solubility Studies
- Quinazolinone synthesis and applications
- Click Chemistry and Applications
- Synthesis of Organic Compounds
- Analytical Chemistry and Chromatography
- Analytical Methods in Pharmaceuticals
- Sesame and Sesamin Research
- Synthesis of Tetrazole Derivatives
- Metal complexes synthesis and properties
- Innovative Microfluidic and Catalytic Techniques Innovation
- Pharmacological Effects and Assays
- Pesticide Residue Analysis and Safety
- Microwave-Assisted Synthesis and Applications
- Microbial Natural Products and Biosynthesis
- Cancer Mechanisms and Therapy
- Synthesis and pharmacology of benzodiazepine derivatives
- Chemical Reaction Mechanisms
- Inorganic and Organometallic Chemistry
- Spectroscopy and Chemometric Analyses
Atmiya University
2023-2024
RK University
2020-2023
Saurashtra University
2018-2022
A one pot water mediated synthesis of sesamol analogous using Betti Base synthetic approach. The reaction was optimized with various solvents and catalysts, but the product formed a high yield in aqueous ethanol condition. examined strategy offers many advantages such as green solvent, purification without column chromatography, catalyst-free synthesis. synthesized molecules were investigated for molecular docking DFT studies. In silico parameter showed that compound 4h has lowest affinity...
A rapid and efficient method has been developed for one-pot synthesis of some newly designed tetrahydropyrimidine derivatives with aid 1,3,4-oxadiazole containing aldehyde, substituted acetoacetanilide thiourea/guanidine in the occurrence microwave irradiation. The significant yield products, atom economy, less time consuming, catalyst-free were considered preferences All synthesized compounds characterized by 1H NMR, 13C IR, mass spectrometry techniques. evaluated bioassay vitro...
A new series of pyrrolobenzodiazepine derivatives containing 1,2,3-triazoles moiety has been designed and developed via Cu(I)-catalyzed azide-alkyne cycloaddition reaction, click chemistry synthetic aspect under microwave irradiation. The reaction curtained in diverse azide derivatives, solvent ratio, catalyst for different time duration. studied with substrate scope proposed mechanism also projected. Synthesized compounds screening vitro anticancer activity antimicrobial activity.
Selexipag belongs to a class of medicines known as IP prostacyclin receptor agonists used treat pulmonary arterial hypertension. A simple and sensitive LC-MS/MS method has been developed for the identification process related impurities in API. The was using Zorbax C18 15 × 0.46 cm, 5μ column with gradient program at 35 0C flow rate 1.0 mL/min. Detection carried out by MS/MS an ESI detector. Stress conditions were established exposing drug acidic, alkaline, oxidative, thermal photolytic...
A series of novel 1,3,4-oxadiazole based Schiff base derivatives were designed and synthesized using the efficient strategy with excellent yields. Synthesized molecules evaluated in vitro antibacterial studies contradiction microorganisms, namely Escherichia coli , Klebsiella pneumoniae, Bacillus subtilis megaterium . The bioassay result revealed that most tested compounds good to moderate inhibition against microorganisms. Some among them show inhibitory effects towards Gram-positive...
Abstract.
We report a new method for the efficient and rapid synthesis of ( 2-butyl-5-nitrobenzo[b]furan-3-yl)[4-(substituted ethynyl)phenyl]methanones using Pd-Cu catalyzed microwave-assisted Sonogashira coupling reaction.In comparison to conventional heating procedure, time effort are significantly reduced in present method, without side-product formation.Microwave irradiation considerably accelerated formation (2-butyl-5-nitrobenzo[b]furan-3-yl)[4-(substituted ethynyl)phenyl]methanone analogues.O O...
Abstract A novel route has been established for the synthesis of pyrido[3,4‐ d ]pyridazin‐1(2 H )‐one derivative. Synthesis intermediate 4‐methyl‐7‐(piperazin‐1‐yl)pyrido[3,4‐ carried out in presence Pd(PPh 3 ) 2 Cl catalyst. Ten derivatives were synthesized, isolated, and characterized by various spectroscopic techniques. All synthesized molecules screened silico parameters evaluated α‐glucosidase α‐amylase inhibitory assay. Furthermore, all anticancer activity against human lung cell line...
Selexipag belongs to group of drugs called IP prostacyclin receptor agonists used in the treatment pulmonary arterial hypertension. A simple and sensitive LC-MS/MS method has been developed for identification process related impurities API. The was using a Zorbax C18 (15 cm × 0.46 x 5μ) column at 35 0C with gradient program flow rate 1.0 mL/min. detection performed by MS/MS ESI detector. Stress conditions were established exposing drug acid, base, oxidation, thermal photolytic stress....
A novel series of tetrahydropyrimidine derivatives containing azepino indole and aryl substitution was achieved by a multicomponent synthetic approach using Biginelli condensation. Various catalysts were employed in the reactions for yield increment but trimethylsilyl chloride gave highest yield. Moreover, all synthesized molecules checked vitro antidiabetic potential. In addition, molecular docking these studied barley alpha-amylase isozyme 1 (amy1) (1RPK). The result revealed that...