The new compounds 1-aryl-3-{1-phenyl-3-[p (methylthio)phenyl]pyrazol-4-yl}-2-propen-1-ones 2a?l were prepared by the condensation of 1-phenyl-3-[p (methylthio)phenyl]-4-formylpyrazole 1 with different aryl ketones. Compounds in reaction hydrazine hydrate yielded 3-aryl-5-{1-phenyl-3-[p-(methylthio)phenyl]pyrazol-4 yl}-4,5-dihydro-(1H)-pyrazoles 3a?l and presence glacial acetic acid gave 1-acetyl-3-aryl 5-{1-phenyl-3-[p-(methylthio)phenyl]pyrazol-4-yl}-4,5 dihydro-(1H)-pyrazoles 4a?l. These...

The objective of the current study was to develop and validate a simple, precise accurate isocratic stability-indicating reversed-phase high-performance liquid chromatography (RP-HPLC) assay method for determination spironolactone furosemide in solid pharmaceutical dosage forms. Isocratic RP-HPLC separation achieved on an SGE 150 × 4.6 mm SS Wakosil II 5C8RS 5-μm column using mobile phase acetonitrile–ammonium acetate buffer (50:50, v/v) at flow rate 1.0 mL/min. detection carried out 254 nm...

Background . Schwannomas, also known as neurilemmomas, are benign peripheral nerve sheath tumors. They originate from any covered with schwann cell sheath. Schwannomas constitute 25–45% of tumors the head and neck. About 4% neck schwannomas present a sinonasal schwannoma. Brachial plexus schwannoma only about 5% schwannomas. Cervical vagal 2–5% neurogenic Methods We case series 5 patients schwannomas, one arising maxillary branch trigeminal in sinus, second brachial plexus, third cervical...

A simple, precise, and accurate RP-HPLC method has been developed validated for the simultaneous assay of Telmisartan Cilnidipine in tablets. Isocratic was on Waters C18 <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mn>250</mml:mn><mml:mo>×</mml:mo><mml:mn>4.6</mml:mn></mml:math> mm, 5 μ m column using mobile phase as acetonitrile (ACN): buffer pH 3.0 with orthophosphoric acid (68 : 32) at a flow rate 1.0 mL/min detection carried out 245 nm photodiode array detector....

Simple and rapid reverse phase high-performance liquid chromatography (RP-HPLC) method was developed validated using solid extraction (SPE) technique for the determination of Azilsartan Medoxomil Potassium (AMP) in human plasma; detection carried out by photo diode array detector. Chromatographic separation analyte AMP achieved within 7.5 min Waters symmetry C 18 (4.6 × 250 mm, 5 µm) column, mobile 25 mM ammonium acetate buffer (pH 5.5): acetonitrile 55 : 45 v/v, flow rate 1.0 mL/min, at 254...

An efficient and simple three-component domino synthesis of some new dihydropyrimidines (DHPMs) from aromatic aldehydes, 1,3-dicarbonyl compounds N-(3-chloro-4-fluorophenyl)urea using molecular iodine as catalyst is described. The 1-substituted were isolated in good to excellent yields (78-90%) within a short reaction time (4-6 h) at ambient temperature. biological evaluation revealed that the newly synthesized (4a-i 5a-i) exhibited moderate antimycobacterial activity against Mycobacterium...

An efficient and simple one-pot synthesis of some new symmetrical, unsymmetrical Nsubstituted Hantzsch 1,4-dihydropyridines using molecular iodine as catalyst from an aldehyde, a 1,3-dicarbonyl compound ammonium acetate / aromatic amine in ethanol is described.This method has the advantage good to excellent yields (80-95%) short reaction times (2.5-5 h) at ambient temperature.

Abstract Polyethylene glycol‐400 (PEG‐400) is a recyclable and rapid reaction medium for synthesizing new series of 4‐(3‐[substitutedphenyl]‐4,5‐dihydro‐1‐phenyl‐1 H ‐pyrazol‐5‐yl)‐1 ‐imidazoles in two‐step procedures by condensation 1 ‐imidazole‐4‐carbaldehyde various acetophenones to form chalcones followed base‐catalyzed cyclization employing phenyl hydrazine catalyst‐free approach. The way projected approach provides easy work‐up, less time, avoids metal‐based toxic catalysts, high...

The required compounds N-aryl-N'-(3-chloro-2-benzo[b]thenoyl)-thioureas 1a-k were prepared by condensing 3-chloro-2-benzo[b]thenoyl chloride with different arylamines using ammonium thiocyanate, which in turn when treated chloroacetic acid, yielded 1-aryl-3-(3-chloro-2-benzo[b]thenoyl)thiohydantoins 2a-k, while the presence of sodium acetate 2-arylimino-3-(3-chloro-2-benzo[b]thenoyl)-4-thiazolidinones 3a-k. All synthesized screened for their antitubercular and antimicrobial activities. Some...

A simple, precise, and accurate isocratic reversed-phase (RP) stability-indicating column high-performance liquid chromatographic (HPLC) assay method was developed validated for determination of nebivolol in solid pharmaceutical dosage forms. Isocratic RP-HPLC separation achieved on a Phenomenex Luna C8 (2) (250 mm x 4.6 id, 5 microm particle size) using mobile phase composed acetonitrile-pH 3.5 phosphate buffer (35 + 65, v/v) at flow rate 1.0 mL/min, detection performed 280 nm photodiode...

Some new N-(4-chlorophenyl)-6-methyl-4-aryl-2-thioxo-1,2,3,4-tetrahydro pyrimidine-5-carboxamide 4(a–h) were synthesized by the reaction of N-(4-chlorophenyl)-3-oxobutanamide, thiourea and different aromatic aldehydes. The synthesis N-(4-chlorophenyl)-7-methyl-5-aryl-2,3-dihydro-5H-thiazolol[3,2-a]pyrimidine-6-carboxamide 5(a–h) was accomplished cyclocondensation 1,2,3,4-tetrahydropyrimidine-2-thiones 1,2-dibromoethane. structures these compounds have been proved IR, 1H-NMR, Mass spectral...

Carica papaya Linn. is one of the valuable plant used for various purposes in medicinal field. Leaves, fruit and seeds C. are as ethnomedicine. This work describes biochemical constituents leaves . Fresh samples were collected during month January, 2013 from different parts Bhuj Kachchh district (Gujarat), India. The purpose study was to evaluate composition growing semi-arid region Gujarat based on result justify its importance treatments diseases. dried further analyzed like Ca 2+ , Mg Na...

Abstract In the current research framework, an efficient and greener synthesis has been developed for novel isoxazole scaffolds one‐pot three‐component reaction. We have a new method convenient rapid of 4‐(substituted‐1 H ‐pyrazol‐4‐yl)methylene)‐3‐isopropylisoxazol‐5(4 )‐ones via reaction between methyl 4‐methyl‐3‐oxovalerate, hydroxylamine hydrochloride various pyrazole aldehyde in presence pyridine as base, water:EtOH (1:1) act solvent under conventional ultrasonic irradiation methods....

A new series of pyrrolobenzodiazepine derivatives containing 1,2,3-triazoles moiety has been designed and developed via Cu(I)-catalyzed azide-alkyne cycloaddition reaction, click chemistry synthetic aspect under microwave irradiation. The reaction curtained in diverse azide derivatives, solvent ratio, catalyst for different time duration. studied with substrate scope proposed mechanism also projected. Synthesized compounds screening vitro anticancer activity antimicrobial activity.

A simple, efficient and modified Biginelli procedure was carried out for the synthesis of tetrahydropyrimidines 4a-o by a solvent-free catalyst-free condition, condensation 1,3-dicarbonyl compound 1, arylaldehydes 2 urea/thiourea 3. Neat reactants subjected to microwave irradiation gave required products more quickly in better yield comparison traditional methodologies.The observed yields improvement reaction rates are due solvent free conditions coupled with use radiation.

Omeprazole is widely prescribed in the form of enteric-coated formulations, due to rapid degradation drug acidic condition stomach. In current article, we are reporting development and complete validation a stability indicating chiral high-performance liquid chromatography (HPLC) method for enantioselective analysis omeprazole formulations. A precise sensitive enantiomeric separation was obtained on Chiralcel OD-H analytical column (250mm × 4.6 mm, 5μm particle size) using normal phase...

The objective of the current study was development a simple, precise and accurate isocratic reversed-phase stability indicating Ultra Performance Liquid Chromatography [UPLC] assay method validated for determination ticlopidine hydrochloride in solid pharmaceutical dosage forms. Isocratic separation achieved on Zorbax SB-C18 (50 mm × 4.6 mm, 1.8 μm) column using mobile phase methanol-0.01 M ammonium acetate buffer, pH 5.0 (80:20, v/v) at flow rate 0.8 ml min(-1), injection volume 4.0 μl...