A5007269611- Synthesis and biological activity
- Analytical Methods in Pharmaceuticals
- Analytical Chemistry and Chromatography
- Multicomponent Synthesis of Heterocycles
- Photochemistry and Electron Transfer Studies
- Thermodynamic properties of mixtures
- Free Radicals and Antioxidants
- Thermal and Kinetic Analysis
- Surfactants and Colloidal Systems
- Pesticide Residue Analysis and Safety
- Synthesis and Reactions of Organic Compounds
- Crystallography and molecular interactions
- Nonlinear Optical Materials Research
- Metal Extraction and Bioleaching
- Synthesis of Tetrazole Derivatives
- Pharmacological Effects and Assays
- Metal complexes synthesis and properties
- Computational Drug Discovery Methods
- Click Chemistry and Applications
- Inorganic and Organometallic Chemistry
- Crystal structures of chemical compounds
- Curcumin's Biomedical Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Microbial Natural Products and Biosynthesis
- Catalysis and Oxidation Reactions
RK University
2022-2024
Atmiya University
2022-2024
Saurashtra University
2015-2017
A one pot water mediated synthesis of sesamol analogous using Betti Base synthetic approach. The reaction was optimized with various solvents and catalysts, but the product formed a high yield in aqueous ethanol condition. examined strategy offers many advantages such as green solvent, purification without column chromatography, catalyst-free synthesis. synthesized molecules were investigated for molecular docking DFT studies. In silico parameter showed that compound 4h has lowest affinity...
Pendimethalin and metribuzin are combined to a suspoemulsion (SE) formulation that is treated as pre-emergence early post emergence herbicide. A simple reverse phase high performance liquid chromatography (RP-HPLC) method has been validated applied for the simultaneous analysis of pendimethalin contents in formulation. The mobile was acetonitrile: water (65:35v/v) at flow rate 1.0 mL/min, quantification accomplished 237 nm. Hypersil ODS column used method's development validation....
Selexipag belongs to a class of medicines known as IP prostacyclin receptor agonists used treat pulmonary arterial hypertension. A simple and sensitive LC-MS/MS method has been developed for the identification process related impurities in API. The was using Zorbax C18 15 × 0.46 cm, 5μ column with gradient program at 35 0C flow rate 1.0 mL/min. Detection carried out by MS/MS an ESI detector. Stress conditions were established exposing drug acidic, alkaline, oxidative, thermal photolytic...
A series of bisphenol-C derivatives was synthesized by condensing with benzylchloride, alkylchloroacetates and alkylchloroformates in the presence anhyd. K2CO3 THF using catalytic amount PEG-600. The compounds were characterized FTIR, 1HNMR, 13CNMR MS; assayed for their antibacterial activity against S. aureus MTCC-96, B. subtilis MTCC-441, E. coli MTCC-443, typhi MTCC-98 antifungal A. niger MTCC-282 clavatus MTCC-1323 at different concentrations compared standard drugs. minimum inhibition...
Objective: A simple, sensitive, and accurate in-vitro dissolution method has been developed for Olmesartan Medoxomil (OLM), Chlorthalidone (CHLR) & Cilnidipine (CIL) drug combination according to USP testing methodologies with different discriminating mediums validated as per ICH guidelines. Methods: The profile was obtained using 900 ml of phosphate buffer pH 6.8 1.0% SLS at 37 °C ± 0.5 medium II (paddle) 75 rpm. average % release above 80% within 45 minutes the combination. evaluated...
Aryl esters of 1,1’-bis(4-hydroxyphenyl)cyclohexane (bisphenol-C) were synthesized by condensing bisphenol-C with aryl acid chlorides using triethylamine as a catalyst and ethyl acetate solvent at room temperature.The compounds characterized FTIR, 1HNMR, 13CNMR MS; assayed for their antibacterial activity against S. aureus MTCC-96, B. subtilis MTCC-441, E. coli MTCC-443, typhi MTCC-98 antifungal A. niger MTCC-282 clavatus MTCC-1323 compared standard drugs. The minimum inhibition...
Polmacoxib (POL) has been approved for treatment of patients with Osteoarthritis. A simple, sensitive, and selective method was developed validated the determination POL its process-related impurities. Chromatographic separation achieved on Kromasil C18 column 250 mm x 4.6 mm, 5µm using gradient elution mobile phase containing 10 mM ammonium acetate buffer acetonitrile in initial ratio 90:10 % v/v. The chromatographic condition optimized such as a flow rate 1.2 ml/min, UV detection at 232...
Density ( ρ ), viscosity η) , ultrasonic speed U and thermo-acoustical parameters such as specific acoustical impedance (Z), adiabatic compressibility κ a internal pressure π free volume V f inter molecular path length L Van der Waals constant b viscous relaxation time τ classical absorption coefficient (α/f 2 ) cl Rao’s molar sound function R m solvation number S n Gibbs energy of activation (ΔG* enthalpy ΔH* entropy ΔS* biologically active 1,1’-bis (3-methyl-4-carboxyethylphenoxy)...
The crystal structure of 1,1’-diylbis (2-methyl-4-phenylene) bis (2-nitrobenzoate) cyclohexane (NBM-2) has been determined by X-ray crystallographic technique. Single crystals were grown slow evaporation NBM-2 crystallized in the triclinic lattice having space group P-1. Both phenyl rings are perpendicular to ring chair conformation. showed both inter-and intramolecular interactions. also supported FT-IR, 1 HNMR, 13 C NMR, MS techniques. thermal behaviour studied TGA and DSC techniques at...
The crystal structure of 1,1’-diylbis (2-methyl-4-phenylene) bis (2-nitrobenzoate) cyclohexane (NBM-2) has been determined by X-ray crystallographic technique. Single crystals were grown slow evaporation NBM-2 crystallized in the triclinic lattice having space group P-1. Both phenyl rings are perpendicular to ring chair conformation. showed both inter-and intramolecular interactions. also supported FT-IR, 1 HNMR, 13 C NMR, MS techniques. thermal behaviour studied TGA and DSC techniques at...
Density ( ρ ), viscosity η) , ultrasonic speed U and thermo-acoustical parameters such as specific acoustical impedance (Z), adiabatic compressibility κ a internal pressure π free volume V f inter molecular path length L Van der Waals constant b viscous relaxation time τ classical absorption coefficient (α/f 2 ) cl Rao’s molar sound function R m solvation number S n Gibbs energy of activation (ΔG* enthalpy ΔH* entropy ΔS* biologically active 1,1’-bis (3-methyl-4-carboxyethylphenoxy)...
Selexipag belongs to group of drugs called IP prostacyclin receptor agonists used in the treatment pulmonary arterial hypertension. A simple and sensitive LC-MS/MS method has been developed for identification process related impurities API. The was using a Zorbax C18 (15 cm × 0.46 x 5μ) column at 35 0C with gradient program flow rate 1.0 mL/min. detection performed by MS/MS ESI detector. Stress conditions were established exposing drug acid, base, oxidation, thermal photolytic stress....
A novel series of tetrahydropyrimidine derivatives containing azepino indole and aryl substitution was achieved by a multicomponent synthetic approach using Biginelli condensation. Various catalysts were employed in the reactions for yield increment but trimethylsilyl chloride gave highest yield. Moreover, all synthesized molecules checked vitro antidiabetic potential. In addition, molecular docking these studied barley alpha-amylase isozyme 1 (amy1) (1RPK). The result revealed that...