A5073809712- Synthesis and biological activity
- Multicomponent Synthesis of Heterocycles
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Reactivity of Heterocycles
- Synthesis and Biological Evaluation
- Click Chemistry and Applications
- Quinazolinone synthesis and applications
- Synthesis of Tetrazole Derivatives
- Computational Drug Discovery Methods
- Analytical Methods in Pharmaceuticals
- Pharmacological Effects of Natural Compounds
- Nanoparticles: synthesis and applications
- Adsorption and biosorption for pollutant removal
- Morinda citrifolia extract uses
- Analytical Chemistry and Chromatography
- Lung Cancer Treatments and Mutations
- Cancer Mechanisms and Therapy
- Nanomaterials for catalytic reactions
- Chronic Myeloid Leukemia Treatments
- Toxin Mechanisms and Immunotoxins
- Spectroscopy and Chemometric Analyses
- Synthesis of Organic Compounds
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Fungal Plant Pathogen Control
- Metal complexes synthesis and properties
RK University
2018-2024
Abstract A modest, efficient, and mild synthetic procedure has been developed for the synthesis of novel series 1,3,4‐oxadiazole containing azaspirocycles derivatives. The reaction derivative with diverse azaspiro compounds under room temperature condition helps sodium iodide catalyst polar aprotic solvent. Numerous compensations this strategy embrace less time required, yield increment, consumption all reactants, condition. All synthesized evaluated in vitro antidiabetic antibacterial...
A one pot water mediated synthesis of sesamol analogous using Betti Base synthetic approach. The reaction was optimized with various solvents and catalysts, but the product formed a high yield in aqueous ethanol condition. examined strategy offers many advantages such as green solvent, purification without column chromatography, catalyst-free synthesis. synthesized molecules were investigated for molecular docking DFT studies. In silico parameter showed that compound 4h has lowest affinity...
A rapid and efficient method has been developed for one-pot synthesis of some newly designed tetrahydropyrimidine derivatives with aid 1,3,4-oxadiazole containing aldehyde, substituted acetoacetanilide thiourea/guanidine in the occurrence microwave irradiation. The significant yield products, atom economy, less time consuming, catalyst-free were considered preferences All synthesized compounds characterized by 1H NMR, 13C IR, mass spectrometry techniques. evaluated bioassay vitro...
A new series of 4-((5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl)methoxy)-N-(benzylidene derivatives)benzenamine (5a-k) have been synthesized and were screened for their in vitro antibacterial activity against Gram-positive bacteria (Pseudomonas aeruginosa, Streptococcus pyogenes), Gram-negative (Escherichia coli, Staphylococcus aureus) antifungal (Candida albicans, Aspergillus niger, clavatus). Synthesized compounds characterized by IR, mass (MS), 1H NMR 13C spectra. The 5b, 5c, 5g 5i showed...
This work involves creating and characterizing stable polymorphic forms of Lenvatinib mesylate while ensuring pharmaceutical purity. The process is optimized uses various analytical techniques such as thermal analysis, powder X-ray diffraction, differential scanning calorimetry to examine these forms. Using techniques, can be synthesized on a commercial scale with high efficiency purity, including two new polymorphs (form 1 2) that are highly pure. These findings provide valuable insights...
Background: Plumbago zeylanica plant belongs to Plumbaginaceae . The is reported for many pharmacological activities. Aim: objective of the study was identify fatty acids and non-polar chemical compounds in leaves Materials methods: Petroleum ether extract prepared using soxhlet apparatus. Saponifiable unsaponifiable matter separated with saponification process. To saponifiable further esterification performed. Gas chromatography mass spectrometry analysis performed both fractions. All acid...
A series of novel 1,3,4-oxadiazole based Schiff base derivatives were designed and synthesized using the efficient strategy with excellent yields. Synthesized molecules evaluated in vitro antibacterial studies contradiction microorganisms, namely Escherichia coli , Klebsiella pneumoniae, Bacillus subtilis megaterium . The bioassay result revealed that most tested compounds good to moderate inhibition against microorganisms. Some among them show inhibitory effects towards Gram-positive...
Abstract.
Abstract A novel route has been established for the synthesis of pyrido[3,4‐ d ]pyridazin‐1(2 H )‐one derivative. Synthesis intermediate 4‐methyl‐7‐(piperazin‐1‐yl)pyrido[3,4‐ carried out in presence Pd(PPh 3 ) 2 Cl catalyst. Ten derivatives were synthesized, isolated, and characterized by various spectroscopic techniques. All synthesized molecules screened silico parameters evaluated α‐glucosidase α‐amylase inhibitory assay. Furthermore, all anticancer activity against human lung cell line...