A5080592581- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- T-cell and Retrovirus Studies
- Immune Cell Function and Interaction
- HIV/AIDS Research and Interventions
- Hepatitis C virus research
- Immunotherapy and Immune Responses
- Click Chemistry and Applications
- Cytomegalovirus and herpesvirus research
- RNA Interference and Gene Delivery
- Pneumocystis jirovecii pneumonia detection and treatment
- Biochemical and Molecular Research
- Carbohydrate Chemistry and Synthesis
- Herpesvirus Infections and Treatments
- Animal Disease Management and Epidemiology
- Fluorine in Organic Chemistry
- Virus-based gene therapy research
- Synthesis and Biological Evaluation
- Hepatitis B Virus Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Chemical Synthesis and Analysis
- Vector-Borne Animal Diseases
- Synthesis and biological activity
- Drug Transport and Resistance Mechanisms
- Respiratory viral infections research
Kagoshima University
2016-2025
Hokkaido University
1994-2024
Joint Research Center
2020
Japan Science and Technology Agency
2006-2016
Birla Institute of Technology, Mesra
2016
Shibuya (Japan)
2014
The University of Tokyo
1996-2010
Chemotherapy Foundation
2010
Osaka University
2007-2010
Showa University
1991-2009
The β-chemokine receptor CCR5 is considered to be an attractive target for inhibition of macrophage-tropic (CCR5-using or R5) HIV-1 replication because individuals having a nonfunctional (a homozygous 32-bp deletion in the coding region) are apparently normal but resistant infection with R5 HIV-1. In this study, we found that TAK-779, nonpeptide compound small molecular weight ( M r 531.13), antagonized binding RANTES (regulated on activation, T cell expressed and secreted) CCR5-expressing...
Several sulfated polysaccharides (dextran sulfate, pentosan polysulfate, fucoidan, and carrageenans) proved to be potent inhibitors for herpes simplex virus, human cytomegalovirus, vesicular stomatitis Sindbis immunodeficiency virus. They were moderately inhibitory vaccinia virus but not adenovirus, coxsackievirus, poliovirus, parainfluenza reovirus. These results indicate that, with the exception of enveloped viruses are specifically susceptible activity polysaccharides.
The sulfated polysaccharides dextran sulfate and heparin have proved to be potent selective inhibitors of human immunodeficiency virus type 1 (HIV-1) in vitro. Dextran (Mr 5000) 15,000) completely protected MT-4 cells against HIV-1-induced cytopathogenicity at a concentration 25 micrograms/ml. Their 50% inhibitory concentrations were 9.1 micrograms/ml (dextran sulfate) 7.0 (heparin), respectively. No toxicity for the host was observed with these compounds 625 anti-HIV-1 activity heparins...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA novel lead for specific anti-HIV-1 agents: 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymineTadashi Miyasaka, Hiromichi Tanaka, Masanori Baba, Hiroyuki Hayakawa, Richard T. Walker, Jan Balzarini, and Erik De ClercqCite this: J. Med. Chem. 1989, 32, 12, 2507–2509Publication Date (Print):December 1, 1989Publication History Published online1 May 2002Published inissue 1 December...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT3'-Substituted 2',3'-dideoxynucleoside analogs as potential anti-HIV (HTLV-III/LAV) agentsPiet Herdewijn, Jan Balzarini, Erik De Clercq, Rudi Pauwels, Masanori Baba, Samuel Broder, and Hubert VanderhaegheCite this: J. Med. Chem. 1987, 30, 8, 1270–1278Publication Date (Print):August 1, 1987Publication History Published online1 May 2002Published inissue 1 August...
A study of the structure-activity relationship a series newly synthesized phosphonylmethoxyalkyl purine and pyrimidine derivatives revealed that several adenine substituted at N9 position by 2-phosphonylmethoxyethyl (PME) group inhibited human immunodeficiency virus (HIV)-induced cytopathogenicity HIV antigen expression in vitro concentrations significantly below toxicity threshold for host cells. In terms anti-HIV potency MT-4 cells, PME 2,6-diaminopurine derivative (50% effective dose...
A series of bicyclams have been shown to be potent and selective inhibitors human immunodeficiency virus (HIV). The compounds are inhibitory the replication various HIV-1 HIV-2 strains in T-cell systems, including peripheral blood lymphocytes, at 0.14-1.4 microM, without being toxic host cells 2.2 mM. bicyclam JM2763 is active against 3'-azido-3'-deoxythymidine (zidovudine; AZT)-resistant acts additively with AZT. Mechanism action studies revealed that (i.e., JM2763) interact an early event...
9-(2-Phosphonylmethoxyethyl)adenine (PMEA) is a potent and selective inhibitor of the replication human immunodeficiency virus (HIV) in vitro T-lymphocyte MT-4, H9, ATH8 cells. PMEA also inhibits Moloney murine sarcoma (Mo-MSV)-induced transformation C3H embryo fibroblasts. Moreover, causes dose-dependent suppression tumor formation associated mortality mice inoculated with Mo-MSV. At dose 50 or 20 mg/kg per day effected 90-100% protection against Mo-MSV-induced mortality. Even as low 1 to 5...
Abstract Nanoparticles are considered to be efficient tools for inducing potent immune responses by an Ag carrier. In this study, we examined the effect of Ag-carrying biodegradable poly(γ-glutamic acid) (γ-PGA) nanoparticles (NPs) on induction in mice. The NPs were efficiently taken up dendritic cells (DCs) and subsequently localized lysosomal compartments. γ-PGA strongly induced cytokine production, up-regulation costimulatory molecules, enhancement T cell stimulatory capacity DCs. These...
In the search for 1-[(2-hydroxyethoxy)-methyl]-6-(phenylthio)thymine (HEPT) derivatives, we have found several 5-ethyl-6-(phenylthio)uracil analogues to be highly potent and selective inhibitors of human immunodeficiency virus (HIV) type 1. 1-Benzyloxymethyl-5-ethyl-6-phenylthiouracil, most congener series, inhibits HIV-1 replication in a variety cell systems, including peripheral blood lymphocytes, at concentration 1.5-7.0 nM, which is lower by factor 10(3) than 50% antivirally effective...
The combined antiviral effects of various 2',3'-dideoxynucleosides and ribavirin on the replication human immunodeficiency virus type 1 in MT-4 cells have been examined. Ribavirin antagonized activity pyrimidine (3'-azido-2',3'-dideoxythymidine, 2',3'-dideoxythymidin-2'-ene, 2',3'-dideoxycytidine, 2',3'-dideoxycytidin-2'-ene), but enhanced purine (2',3'-dideoxyadenosine 2',3'-dideoxyguanosine). Combinations with each other were also These combinations resulted an additive to subsynergistic effect.