A5015363073- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
- Cancer Research and Treatments
- Bioinformatics and Genomic Networks
- Cancer therapeutics and mechanisms
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Synthesis and Biological Evaluation
- Monoclonal and Polyclonal Antibodies Research
- X-ray Diffraction in Crystallography
- Cancer-related Molecular Pathways
- RNA Interference and Gene Delivery
- Crystallization and Solubility Studies
- MicroRNA in disease regulation
- Andrographolide Research and Applications
- Angiogenesis and VEGF in Cancer
- Phytochemicals and Medicinal Plants
- Heavy metals in environment
- Enzyme Production and Characterization
- Gut microbiota and health
- Cell Adhesion Molecules Research
- Biochemical effects in animals
- Cancer, Stress, Anesthesia, and Immune Response
- Metabolism and Genetic Disorders
- Trace Elements in Health
The University of Texas Health Science Center at San Antonio
2023
Central University of Punjab
2020-2022
Breast cancer remains the most commonly diagnosed worldwide and exhibits a poor prognosis. The induction of genetic changes deregulates several genes that increase disposal towards this life-threatening disease. CHAC2, member glutathione degrading enzyme family has been shown to suppress gastric colorectal progression, however, expression CHAC2 in breast not reported. We did an analysis patients from various online tools like UALCAN, GEPIA2, GENT2, TIMER2, bcGenExminer v4.8. Further, we used...
Abstract Invading tumor cells develop membrane protruding structures called invadopodia to invade and metastasize. Previously, we have reported the role of formin-binding protein-17 (FBP17) in extracellular matrix degradation formation breast cancer cells. Here, report a novel axis between tumor-suppressor p53 FBP17. We observed that cell lines with mutant express FBP17 higher level. The expression was reduced upon stabilizing wild-type p53. Furthermore, immunohistochemistry analysis tissue...
Abstract 5‐(2‐Nitrophenyl)‐1‐aryl‐1 H ‐pyrazoles are designed as topoisomerase (Topo) inhibitors, synthesised and assessed for their anticancer properties against breast (MDA‐MB‐231 MCF7), lung (A549), colorectal (HCT116) cancer cell lines. All the compounds induced significant cytotoxicity at low micromolar concentration. The compound 5e exerted potential effects on lines a level (IC 50 <2 μM), showed negligible toxicity towards normal cells. Compound 5 e reduced reactive oxygen species...
Abstract Background: Cancer cells are constantly exposed to harsh conditions like nutrient deprivation, hypoxia, and calcium imbalance leading the induction of UPR. In its early phase, UPR aims restore homeostasis while prolonged stress leads apoptosis. Thus, it is not surprising observe that expression components has been reported both promote as well suppress tumorigenesis. Studies have shown Cation transport regulator homolog 1 (CHAC1) plays a dual role in cancer progression. The...