A5025715718- HIV/AIDS drug development and treatment
- Hepatitis C virus research
- HIV Research and Treatment
- Synthesis and Biological Evaluation
- Quinazolinone synthesis and applications
- Synthesis and biological activity
- CO2 Reduction Techniques and Catalysts
- Synthesis and Characterization of Heterocyclic Compounds
- Protein Structure and Dynamics
- Ion channel regulation and function
- Phenothiazines and Benzothiazines Synthesis and Activities
- Carbon dioxide utilization in catalysis
- Enzyme Structure and Function
- Polyoxometalates: Synthesis and Applications
- Biochemical and Molecular Research
- Advanced Photocatalysis Techniques
- Carbohydrate Chemistry and Synthesis
- RNA and protein synthesis mechanisms
- Trace Elements in Health
- Cancer therapeutics and mechanisms
- Gut microbiota and health
- Membrane Separation Technologies
- Hepatitis B Virus Studies
- Force Microscopy Techniques and Applications
- Cardiac electrophysiology and arrhythmias
Indian Institute of Science Education and Research Kolkata
2016-2021
Central China Normal University
2018-2021
GITAM University
2018-2019
Birla Institute of Technology, Mesra
2011-2018
Southwest University
2018
Background Nitrofurantoin is a preferred choice of antibiotic for treating urinary tract infections UTIs caused by vancomycin-sensitive and vancomycin-resistant strains including cases associated with catheter use. Recently there has been an emergence resistance among Enterobacteriaceae Gram negative bacteria this indicates extensively drug resistant XDR phenotype that makes the treatment uncomplicated UTI difficult.Methods Clean catch midstream urine sample was collected from adults after...
We report soft-oxometalate catalytic systems based on various metal oxide catalysts to oxidize H<sub>2</sub>O and utilize the generated H<sup>+</sup>s e<sup>−</sup>s for reduction of CO<sub>2</sub> with a TON 1366 (effectively 1.4 x 10<sup>6</sup>).
Biophysical studies have shown that each molecule of calsequestrin 1 (CASQ1) can bind about 70–80 Ca2+ ions. However, the nature Ca2+-binding sites has not yet been fully characterized. In this study, we employed in silico approaches to identify binding and understand molecular basis CASQ1–Ca2+ recognition. We built protein model by extracting atomic coordinates for back-to-back dimeric unit from recently solved hexameric CASQ1 structure (PDB id: 3UOM) adding missing C-terminal residues...
CASQ (calsequestrin) is a Ca2+-buffering protein localized in the muscle SR (sarcoplasmic reticulum); however, it unknown whether Ca2+ binding to CASQ2 due its location inside rich or preference for over other ions. Therefore major aim of present study was determine how selects metal ions by studying monomer folding and subsequent aggregation upon exposure alkali (monovalent), alkaline earth (divalent) transition (polyvalent) metals. We additionally investigated CPVT (catecholaminergic...
Photocatalytic CO 2 reduction in water is one of the most attractive research pursuits our time. In this article we report a giant polyoxometalate {Mo 368 } based homogeneous catalytic system, which efficiently reduces to formic acid with maximum turnover number (TON) 27,666, frequency (TOF) 4,611 h −1 and external quantum efficiency reaction 0.6%. The system oxidizes releases electrons, these electrons are further utilized for acid. A 8.3 mmol was observed loading 0.3 μmol catalyst. Our...
Calsequestrin (CASQ) exists as two distinct isoforms CASQ1 and CASQ2 in all vertebrates. Although the exhibit unique functional characteristic, structural basis for same is yet to be fully defined. Interestingly, C-terminal region of significant differences both length amino acid composition; forming Dn-motif DEXn-motif CASQ2, respectively. Here, we investigated if motifs possess Ca(2+)-sensitivity affect protein function. Sequence analysis shows that Dn- DEXn-motifs are intrinsically...
Abstract Computer‐aided approaches coupled with medicinal chemistry were used to explore novel carbocyclic nucleosides as potential anti‐hepatitis C virus (HCV) agents. Conformational analyses carried out on 6‐amino‐1 H ‐pyrazolo[3,4‐ d ]pyrimidine (6‐APP)‐based nucleoside analogues, which considered mimetics act HCV RNA‐dependent RNA polymerase (RdRp) inhibitors. Structural insight gained from the modeling studies revealed molecular basis behind these mimetics. The rationally chosen 6‐APP...
Background: Oxadiazole emerged as an important class of heterocyclic compound with diverse biological activities like anticancer, antitubercular, anticonvulsant, anti-tubulin, antimicrobial, anti-inflammatory, antioxidant etc. Objective: The objective this study is to synthesis series twelve substituted N-[(1,3,4-oxadiazol-2- yl)methyl]benzamines (6a-l) and their evaluation antiproliferative agents. Methods: N-[(1,3,4-oxadiazol-2-yl)methyl]benzamines analogues were synthesized per the...
A series of C-7 substituted-2-morpholino-N-(pyridin-2-ylmethyl)quinazolin-4-amine have been synthesized and biochemical assay was examined against α-glucosidase function inhibition activity. structure activity property relationship study experimented to surface the new hit compound. This led identification C-7substituted quinazolines with minimum inhibitory concentrations (MICs) in preffered micromolar range addition interesting physicochemical properties. Biological evaluation yielded eight...
Abstract Series of new 3,3’‐disubstituted chiral ( R )‐BINOL compounds have been synthesized with good yields and short reaction time under microwave‐irradiation. The titled showed great antibacterial activity against gram‐positive gram‐negative organisms. results indicated that two )‐3,3′‐bis(3,5‐difluorophenyl)‐[1,1′‐binaphthalene]‐2,2′‐diol 6 a ) )‐3,3′‐bis(4‐nitrophenyl)‐[1,1′‐binaphthalene]‐2,2′‐diol d which bearing fluoro nitro substitution on phenyl group has displayed highest...
The present studies report the synthesis of a novel graft copolymer "polymethyl methacrylate-grafted oatmeal" (OAT-g-PMMA) using "conventional" technique. Grafting PMMA chains on backbone parent biopolymer (oatmeal) was confirmed through various physicochemical techniques like intrinsic viscosity, FTIR, elemental analysis (C, H, N, S and O), scanning electron microscopy, thermal gravimetric analysis, number-average molecular weight, solubility, 13C-CP/MAS solid-state NMR spectroscopy P-XRD....