A5037245068- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Synthesis and Characterization of Heterocyclic Compounds
- Multicomponent Synthesis of Heterocycles
- Click Chemistry and Applications
- Phenothiazines and Benzothiazines Synthesis and Activities
- Computational Drug Discovery Methods
- Quinazolinone synthesis and applications
- Drug Solubulity and Delivery Systems
- Crystallization and Solubility Studies
- Chemical Reaction Mechanisms
- Synthesis of heterocyclic compounds
- Mosquito-borne diseases and control
- Advancements in Transdermal Drug Delivery
- X-ray Diffraction in Crystallography
- Advanced Drug Delivery Systems
- Fungal Plant Pathogen Control
- Cholinesterase and Neurodegenerative Diseases
- Nanoparticle-Based Drug Delivery
- Cancer therapeutics and mechanisms
- Bioactive Compounds and Antitumor Agents
- Curcumin's Biomedical Applications
- HIV/AIDS drug development and treatment
- Moringa oleifera research and applications
- Garlic and Onion Studies
King Khalid University
2017-2025
International Islamic University Malaysia
2024
Sultan Idris Education University
2024
National University of Malaysia
2023
Universiti Sains Malaysia
1997-2022
Jamia Hamdard
2011-2018
Alwar Pharmacy College
2012-2017
Sultan Haji Ahmad Shah Hospital
2016
Hamdard University
2011-2014
Jordan University of Science and Technology
1996
Spirocyclic compounds isolated from plant and animal origins have important applications in medicinal chemistry. Spiro having cyclic structures fused at a central carbon are of recent interest because their interesting conformational features structural implications for biological systems. heterocycles like spiropyrrolidines oxindole moieties been found to play fundamental roles processes exhibited diversified activity pharmacological therapeutical properties. In view these facts we decided...
Abstract Graphene, owing to its unique chemical structure and extraordinary chemical, electrical, thermal, optical, mechanical properties, has opened up a new vista of applications, specifically as novel sensing platforms. The last decade seen an extensive exploration graphene graphene-based materials either alone or modified with nanoparticles polymers for the fabrication nanoscale biosensors. These biosensors displayed excellent conductivity, high sensitivity, selectivity, good accuracy,...
Pyrazoles are an interesting class of compounds showing potent anticancer activities. Our previous studies have demonstrated the activity pyrazole analogues. Therefore, we focused on developing agents through structure optimization pyrazolyl lead molecule. The derivatives were prepared by appropriate synthetic protocols. antiproliferative activities evaluated using a sulforhodamine B assay against three cancer cell lines. In vitro and in silico molecular docking employing xanthine oxidase...
This research work aimed to develop and evaluate proniosomes for the oral delivery of lipophilic drug Irbesartan (IRB) improve its solubility bioavailability. Proniosomes were formulated using a lipid, surfactant, carrier by slurry method. Based on prepared preliminary trial batches their evaluation, formulation was optimized employing Box–Behnken design (BBD) in which concentrations span 60 (X1), cholesterol (X2), mannitol (X3) used as three independent variables vesicular size (VS) (Y1), %...
The spreading of COVID-19 has posed a risk to global health, especially for lung cancer patients. An investigation is needed overcome the challenges pathophysiology and disease. This study was designed evaluate phytoconstituents in Punica granatum peel (PGP), its anti-lung activity, silico evaluation antiviral potential. GC–MS technique used detect phytoconstituents. Cytotoxicity analyzed using MTT dye, followed by apoptosis, ROS generation, cell cycle phase detection human cells (A549)....
1,3,4-Oxadiazole heterocycles possess a broad spectrum of biological activities. They were reported as potent cytotoxic agents and tubulin inhibitors; hence it is great interest to explore new oxadiazoles targeting polymerization.Two series (5a-h 12a-h) synthesized, structurally related the heterocyclic linked aryl core IMC-038525, NSC 776715, 776716, with further modification by incorporating methylene linker.The 2,5-disubstituted-1,3,4-oxadiazoles synthesized refluxing an equimolar mixture...
Allium sativum L. has been used medicinally and traditionally since antiquity. This study sought to examine the ethanolic extract (ASEE) in inducing apoptosis human triple-negative breast cancer (TNBC) MDA-MB-231 cells molecular interactions of identified components with cell death markers using silico method. Cytotoxicity ASEE was tested on MCF-7, MDA-MB-231, Normal Vero cells. The ROS production, apoptosis, MMP, cycle were conducted utilizing flow cytometer, western blot also performed for...
New hydrazone incorporated triazines were designed and synthesized using an appropriate synthetic route with regard to essential pharmacophores, evaluated for their anticonvulsant activity through maximal electroshock seizure (MES) subcutaneous pentylenetetrazole-induced (scPTZ) screenings. Among the tested compounds, 4-[{2-(5-(3-chlorobenzyl)-3-phenyl-1,2,4-triazine-6-yl)hydrazono}methyl]-N,N-dimethylaniline 6k (MES ED50 54.31, scPTZ 92.01)...
The thiazole ring is found in many pharmaceutical and natural products. In this article, the convenient synthesis of two new hybrid molecules carrying nucleus linked to pyrazole or pyridine rings described. structure synthesized hybrids confirmed by spectroscopic X-ray analysis. Using Hirshfeld analysis, molecular packing thiazolyl-pyrazole 2 controlled weak S…S, S…C, S…H, C…N, N…H, C…C, C…H H…H non-covalent interactions. percentage contributions these contacts are 1.6, 0.2, 22.1, 0.7, 7.9,...
A series of 3-diphenylmethyl-6-substituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole derivatives (4a–j and 5a–d) were synthesized by condensation 4-amino-5-diphenylmethyl-4H-1,2,4-triazole-3-thiol with various substituted aromatic acids aryl/alkyl-isothiocyanates. The structures compounds characterized elemental analysis, IR, 1H NMR, 13C NMR mass spectroscopic studies. These tested in vivo for their anti-inflammatory activity. which showed activity comparable to the standard drug ibuprofen...