A5027999199- Gallbladder and Bile Duct Disorders
- Sarcoma Diagnosis and Treatment
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Phenothiazines and Benzothiazines Synthesis and Activities
- Hernia repair and management
- Synthesis and Biological Evaluation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Diagnosis and Treatment
- Synthesis of Indole Derivatives
- Neuroblastoma Research and Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Head and Neck Cancer Studies
- Gastric Cancer Management and Outcomes
- Catalytic C–H Functionalization Methods
- Multicomponent Synthesis of Heterocycles
- Cancer survivorship and care
- Reconstructive Surgery and Microvascular Techniques
- Chemical Synthesis and Analysis
- Esophageal Cancer Research and Treatment
- Crystallography and molecular interactions
- Cardiac tumors and thrombi
- Lung Cancer Treatments and Mutations
- Abdominal Surgery and Complications
- Bone Tumor Diagnosis and Treatments
Texas A&M University
2019-2025
Army Hospital Research and Referral
2015-2024
Indira Gandhi Institute of Medical Sciences
2017-2024
Nalanda Medical College and Hospital
2023
Command Hospital Air Force
2011-2022
Institute of Cytology and Preventive Oncology
2022
Texas College
2022
Mitchell Institute
2021
College Station Medical Center
2021
Command Hospital
2019-2020
In light of growing global challenge posed by antimicrobial resistance, it is very important to explore alternatives that can target pathogenic microorganisms. One such strategy involves the use peptides (AMPs) and Stigmurin one AMP present in Brazilian scorpion Tityus stigmurus which possesses antimicrobial, antiproliferative antiparasitic activity. The study commenced with successful synthesis characterization its analogues, designated S1 S2. Studies on analogues have demonstrated exhibit...
Background: The management of postoperative pain in hemorrhoidectomy patients represents a major clinical challenge because preoperative oral metronidazole shows inconsistent treatment results. Subjective assessment tools used traditional methods result results they depend on patient-reported measurements. Machine learning models facilitate data-based within settings which enables better decisions thus helping to recover effectively. Objective: research will evaluate the effectiveness given...
This work discloses an electrochemical oxidative cross-coupling of amines with aryl and aliphatic isocyanides. In undivided cell, the reaction proceeds without involving any transition-metal catalyst, oxidant, or toxic reagents providing carbodiimides in good yields, thereby circumventing stoichiometric chemical oxidants, H2 as only byproduct. Moreover, were situ converted into unsymmetrical ureas moderate to yields using electricity ON–OFF strategy.
New, highly stable tricyclic antitubercular ozonides 9 and 10 derived from artemisinin are reported in 39 9% yields, respectively. The ozonide groups of were found to be under strong basic acidic conditions. absolute configuration was confirmed by X-ray crystallography. Ozonide shows promising activity against M. tuberculosis H37Ra H37Rv with MIC values 0.39 3.12 μg/mL,
A metal-free diastereo-/regioselective modular synthetic approach for the synthesis of highly constrained tetrahydroquinoline-fused tetracyclic heterocycles from easily available substrates has been developed. This two-step strategy utilizes an Ugi four-component reaction, followed by intramolecular spirocarbocyclization and iodination reactions in a single operation. The transformation is mild operationally simple, which provides architecturally complex polycyclic with high...
A simple, mild and robust method for the stereoselective synthesis of (E)-methyl α-(3-formyl-1H-indol-2-yl)-β-aryl/alkyl-substituted acrylates via a condensation reaction methyl 2-(3-formyl-1H-indol-2-yl)acetate with several alkyl or aryl aldehydes using L-proline (25 mol%) as catalyst is presented first time. In addition, completely metal free based high yielding methods syntheses highly substituted biologically important carbazoles, γ-carbolines marine alkaloid prenostodione have been...
Abstract In a world where fossil fuels are running out, biofuels one of the best green energy alternatives to made from petroleum due their environmentally beneficial qualities and low cost in comparison with non‐renewable fuels. Biofuels produced cheap renewable sources stored these biomasses can be assimilated create sustainable electricity or heat, which then exploited meet current future societal needs numerous situations. However, production on an industrial scale takes lot time because...
A simple, mild, green, catalytic and general procedure for the direct synthesis of highly functionalized 1-methoxycarbonyl-2-aryl/alkyl-3-nitro-9H-carbazoles has been achieved in water medium via a one-pot domino Michael–Henry/aromatization reaction methyl 2-(3-formyl-1H-indol-2-yl)acetates with aryl/alky-substituted β-nitroolefins under air using DABCO (30 mol%) as an organocatalyst. In addition, bench scale can be performed without toxic organic solvents biologically important new fused...
For the first time, a very simple, efficient, mild, catalytic and one-step procedure for synthesis of series densely functionalized 1-methoxycarbonyl-2-aryl-3-nitro-4-hydroxy-1,2,3,4-tetrahydro-9H-carbazole derivatives has been achieved via domino Michael–Henry reaction methyl 3-formyl-1H-indole-2-acetates with β-nitrostyrenes using DABCO as an organocatalyst. Furthermore, high enantio-(≤92% ee) diastereoselective (≤12 : 1 dr) title compounds excellent yields 9-O-benzylcupreidine (10 mol%) catalyst.
One pot metal-free synthesis of phenanthridines and amides under electrochemical conditions.
Respiratory diseases (RD) are a group of common ailments with rapidly increasing global prevalence, posing significant threat to humanity, especially the elderly population, and imposing substantial burden on society economy. RD represents an unmet medical need that requires development viable pharmacotherapies. While various promising strategies have been devised advance potential treatments for RD, their implementation has hindered by difficulties in drug delivery, particularly critically...
A microwave-assisted, environmentally benign green protocol for the synthesis of functionalized (Z)-3-(2-oxo-2-phenylethylidene)-3, 4-dihydro-2H-benzo[b][1,4]oxazin-2-ones (11a-n) in excellent yields (upto 97%) and (Z)-3-(2-oxo-2-phenylethylidene)-3,4-dihydroquinoxalin-2(1H)-ones (14a-h) 96% yield) are reported. The practical applicability developed methodology were also confirmed by gram scale 11a, 14c 14e; anticancer alkaloid Cephalandole 16 (89% yield). All synthesized compounds 11a-n,...
Abstract To explore the potential of aporphine alkaloids, a novel series functionalized analogues with alkoxy (OCH 3 , OC 2 H 5 7 ) functional groups at C1/C2 ring A and an acyl (COCH COPh) or phenylsulfonyl (SO Ph SO C 6 4 ‐3‐CH functionality N6 position B scaffold were synthesized evaluated for their arachidonic acid (AA)‐induced antiplatelet aggregation inhibitory activity 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) free‐radical‐scavenging antioxidant activity, acetylsalicylic ascorbic as...
The discovery of C-3 tethered 2-oxo-benzo[1,4]oxazines as potent antioxidants is disclosed. All the analogues 20a-20ab have been synthesized via "on water" ultrasound-assisted in excellent yields (upto 98%). compounds evaluated for their vitro antioxidant activities using DPPH free radical scavenging assay well FRAP assay. result showed promising having IC50 values range 4.74 ± 0.08 to 92.20 1.54 μg/mL taking ascorbic acid (IC50 = 4.57 μg/mL) standard reference. In this study, 20b and 20t,...