A5101515768- Supramolecular Self-Assembly in Materials
- Chemical Synthesis and Analysis
- Advanced biosensing and bioanalysis techniques
- Polydiacetylene-based materials and applications
- Polymer Surface Interaction Studies
- Protein Hydrolysis and Bioactive Peptides
- Advanced Drug Delivery Systems
- Advanced Glycation End Products research
- Probiotics and Fermented Foods
- Protein Structure and Dynamics
- Alzheimer's disease research and treatments
- RNA and protein synthesis mechanisms
- Neuroscience and Neuropharmacology Research
Yonsei University
2019-2025
In light of growing global challenge posed by antimicrobial resistance, it is very important to explore alternatives that can target pathogenic microorganisms. One such strategy involves the use peptides (AMPs) and Stigmurin one AMP present in Brazilian scorpion Tityus stigmurus which possesses antimicrobial, antiproliferative antiparasitic activity. The study commenced with successful synthesis characterization its analogues, designated S1 S2. Studies on analogues have demonstrated exhibit...
Although interest in stabilized α-helical peptides as next-generation therapeutics for modulating biomolecular interfaces is increasing, have limited functionality and stability due to their small size. In comparison, ligands based on proteins can make steric clash with targets large Here, we report the design of a monomeric pseudo-isolated α-helix (mPIH) system which behave if they are peptides. The designed contain that do not require any covalent chemical modification, frayed ends,...
The quaternary structure of proteins extends the functionality monomeric proteins. Similarly, self-assembled protein nanostructures (SPrNs) have great potential to improve and complexity proteins; however, difficulty associated with fabrication SPrNs is far greater than that peptides or polymers often requires sophisticated computational design. To make process SPrN formation simpler more intuitive, herein, we devise a strategy adopt an irreversible peptide nanostructure (SPeN) en route...
Detecting amyloid beta (Aβ) in unpurified blood to diagnose Alzheimer's disease (AD) is challenging owing low concentrations of Aβ and the presence many other substances blood. Here, we propose a 3D sensor for AD diagnosis using plasma, with pairs silicon micropillar electrodes comprehensive circuit configuration. The developed synthesized artificial peptide impedance analysis based on maximum signal-to-noise ratio. Its sensitivity selectivity were verified an vitro test samples human serum,...